Aerosol measurement identifies SARS-CoV 2 PCR positive adults compared with healthy controls

Gutmann, Desiree; Scheuch, G.; Lehmkühler, Timon; Herrlich, Laura-Sabine; Landeis, Anton; Hutter, Martin; Stephan, Christoph; Vehreschild, Maria J. G. T.; Khodamoradi, Yascha; Goßmann, Ann-Kathrin; King, Florian; Weis, Frederik; Weiß, M.; Rabenau, Holger F.; Graf, Juergen; Donath, H; Schubert, Ralf; Zielen, Stefan

doi:10.1016/j.envres.2022.114417

Cited by 9 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, differences in respiratory maneuvers as well as surfactant production may influence aerosol production. Children also have a lower respiratory minute Additionally, no infected children were found to breathe more than 595 p/L, whereas so-called superspreaders in studies among adults exhaled >5,000 particles/liter and accounted for 15.6% of infected adults (39). At first glance, our aerosol measurements do not match the data from Gutmann et al (48).…”

Section: Discussioncontrasting

confidence: 80%

“…We found particle concentrations in children to be substantially lower than those in healthy adults, where an average concentration of 252 p/L has been reported previously using the same method (39). This might be due to the lower number of alveoli and terminal bronchioli in children's respiratory tracts, as these structures are thought to be the origin of aerosol production (41,45,46).…”

Section: Discussionsupporting

confidence: 53%

“…Thus, it is tempting to speculate that the delta variant may induce higher levels of aerosols due to higher parenchyma involvement than the omicron variant (55). In addition, Gutman et al showed that patients with respiratory failure and pneumonia had significantly higher aerosol levels than patients with mild COVID-19 infection in ambulatory care (39).…”

Section: Discussionmentioning

confidence: 99%

“…Unlike among adults, there is little knowledge about aerosol emissions among children (39). The question of whether children contribute substantially to the spread of SARS-CoV-2 has not yet been resolved, despite many observational studies being conducted.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children

Schuchmann

Scheuch²,

Naumann³

et al. 2023

Front. Pediatr.

Self Cite

View full text Add to dashboard Cite

BackgroundAvailable data on aerosol emissions among children and adolescents during spontaneous breathing are limited. Our aim was to gain insight into the role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and whether aerosol measurements among children can be used to help detect so-called superspreaders—infected individuals with extremely high numbers of exhaled aerosol particles.MethodsIn this prospective study, the aerosol concentrations of SARS-CoV-2 PCR-positive and SARS-CoV-2 PCR-negative children and adolescents (2–17 years) were investigated. All subjects were asked about their current health status and medical history. The exhaled aerosol particle counts of PCR-negative and PCR-positive subjects were measured using the Resp-Aer-Meter (Palas GmbH, Karlsruhe, Germany) and compared using linear regression.ResultsA total of 250 children and adolescents were included in this study, 105 of whom were SARS-CoV-2 positive and 145 of whom were SARS-CoV-2 negative. The median age in both groups was 9 years (IQR 7–11 years). A total of 124 (49.6%) participants were female, and 126 (50.4%) participants were male. A total of 81.9% of the SARS-CoV-2-positive group had symptoms of viral infection. The median particle count of all individuals was 79.55 particles/liter (IQR 44.55–141.15). There was a tendency for older children to exhale more particles (1–5 years: 79.54 p/L; 6–11 years: 77.96 p/L; 12–17 years: 98.63 p/L). SARS-CoV-2 PCR status was not a bivariate predictor (t = 0.82, p = 0.415) of exhaled aerosol particle count; however, SARS-CoV-2 status was shown to be a significant predictor in a multiple regression model together with age, body mass index (BMI), COVID-19 vaccination, and past SARS-CoV-2 infection (t = 2.81, p = 0.005). COVID-19 vaccination status was a highly significant predictor of exhaled aerosol particles (p < .001).ConclusionDuring SARS-CoV-2 infection, children and adolescents did not have elevated aerosol levels. In addition, no superspreaders were found.

show abstract

Section: Discussioncontrasting

confidence: 80%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children

Schuchmann

Scheuch²,

Naumann³

et al. 2023

Front. Pediatr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Reverse transcription loop-mediated isothermal nucleic acid amplification (RT-LAMP) has emerged as the method of choice among the various isothermal techniques due to its low resource requirement and relative simplicity [13]. The main contributing factor to a rise in LAMP-based diagnostics has been the expiration of Eiken Chemical's key patent on LAMP [29,30]. The US FDA has authorized the emergency use (EUA) of 18 COVID-19 RT-LAMP-based products by 14 developers (as of October 19, 2023) [14].…”

Section: The Best Of Innovation: New Sampling Methods and Testing Tec...mentioning

confidence: 99%

Blazing the trail for innovative tuberculosis diagnostics

Yerlikaya,

Broger,

Isaacs

et al. 2023

Infection

View full text Add to dashboard Cite

The COVID-19 pandemic brought diagnostics into the spotlight in an unprecedented way not only for case management but also for population health, surveillance, and monitoring. The industry saw notable levels of investment and accelerated research which sparked a wave of innovation. Simple non-invasive sampling methods such as nasal swabs have become widely used in settings ranging from tertiary hospitals to the community. Self-testing has also been adopted as standard practice using not only conventional lateral flow tests but novel and affordable point-of-care molecular diagnostics. The use of new technologies, including artificial intelligence-based diagnostics, have rapidly expanded in the clinical setting. The capacity for next-generation sequencing and acceptance of digital health has significantly increased. However, 4 years after the pandemic started, the market for SARS-CoV-2 tests is saturated, and developers may benefit from leveraging their innovations for other diseases; tuberculosis (TB) is a worthwhile portfolio expansion for diagnostics developers given the extremely high disease burden, supportive environment from not-for-profit initiatives and governments, and the urgent need to overcome the long-standing dearth of innovation in the TB diagnostics field. In exchange, the current challenges in TB detection may be resolved by adopting enhanced swab-based molecular methods, instrument-based, higher sensitivity antigen detection technologies, and/or artificial intelligence-based digital health technologies developed for COVID-19. The aim of this article is to review how such innovative approaches for COVID-19 diagnosis can be applied to TB to have a comparable impact.

show abstract

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Cimolai

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Given the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as witnessed early in the coronavirus disease 2019 (COVID‐19) pandemic, concerns arose with the existing methods for virus disinfection and decontamination. The need for SARS‐CoV‐2‐specific data stimulated considerable research in this regard. Overall, SARS‐CoV‐2 is practically and equally susceptible to approaches for disinfection and decontamination that have been previously found for other human or animal coronaviruses. The latter have included techniques utilizing temperature modulation, pH extremes, irradiation, and chemical treatments. These physicochemical methods are a necessary adjunct to other prevention strategies, given the environmental and patient surface ubiquity of the virus. Classic studies of disinfection have also allowed for extrapolation to the eradication of the virus on human mucosal surfaces by some chemical means. Despite considerable laboratory study, practical field assessments are generally lacking and need to be encouraged to confirm the correlation of interventions with viral eradication and infection prevention. Transparency in the constitution and use of any method or chemical is also essential to furthering practical applications.

show abstract

Aerosol measurement identifies SARS-CoV 2 PCR positive adults compared with healthy controls

Cited by 9 publications

References 38 publications

Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children

Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children

Blazing the trail for innovative tuberculosis diagnostics

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Contact Info

Product

Resources

About