Aerosol-phase activity of iodine captured from a triiodide resin filter on fine particles containing an infectious virus

Heimbuch, Brian K.; Harnish, Delbert A.; Balzli, Charles L.; Lumley, April E.; Kinney, Kimberly; Wander, Joseph D.

doi:10.1111/jam.12788

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Previous in vitro studies conducted by various investigators and air purification products manufacturer reported that incorporating poly (styrene-4-[trimethylammonium] methyl triiodide) (PSTI), an oxidative agent to the filter layer provides 2-log increase in viable removal efficiency (VRE) compare to the standard filter layers (14)(15)(16)(17)(18). Others' work suggested that the exposure to the treated resin shortened the half-life for deactivation by at least half; quenching experiments in which the aerosols were trapped in thiosulfate medium showed complete loss of effect by the iodine (19).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Agent Treated Filtering Facepiece Respirators for Inactivation of Airborne Viruses During Environmental Catastrophe

Ali¹

2016

IJIBCS

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Bioterrorism attack within large building using bacterial and viral agents in the form of aerosolized submicron spores may create an unprecedented environmental catastrophe. The filtering facepiece respirator (FFR) can be adopted as the first protection. This study investigated the antimicrobial oxidant's efficacy in diminishing viability of the aerosolized biological agents after passing through the oxidant treated FFR over a period of time. Three FFRs were N95-P100, Triosyn T5000 and Super High Efficiency Particulate Air (HEPA) Medium (SHM). The N95-P100 was the control, whereas, both the T5000 and SHM contained a layer treated with an antimicrobial oxidant. The MS2 bacteriophage agent was aerosolized, passed through the FFRs, and collected in the hot sealed aerosol bags, which were kept for 0-, 1-, 2-, 5-, and 10-minute of residence time before quenching and consuming filter released iodine by a buffer solution (sodium thiosulfate) in all-glass impingers. The viability (plaque forming unit) of the collected microbial agents was quantitated by plaque assays using Single Agar Layer and Escherichia coli. The experimental results for all FFRs were in good agreement with the reported literature. The viability of biological agents for SHM FFR exponentially dropped from 100% to 46%, 28%, 12% and 4% over the period of residence time from 0 minute to 1, 2, 5 and 10 minutes, respectively, this can be interpreted that the half-life was about a minute. Reduction of the viability for T5000 and N95-P100 were very low in the order of 1.4% and 3%, respectively, for all four residence times. The SHM FFR provided the strongest lethal dose of disinfectant to the pathogens than that of N95-P100 and T5000, which can be adopted as mass prophylaxis against airborne submicron-deadly viruses during environmental catastrophe.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Agent Treated Filtering Facepiece Respirators for Inactivation of Airborne Viruses During Environmental Catastrophe

Ali¹

2016

IJIBCS

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Capture of 0.1-μm aerosol particles containing viable H1N1 influenza virus by N95 filtering facepiece respirators

Harnish

Heimbuch

Balzli

et al. 2016

Journal of Occupational and Environmental Hygiene

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Nosocomial infections pose an escalating threat to both patients and healthcare workers (HCWs). A widely recommended device for individual respiratory protection, the N95 filtering facepiece respirator (FFR) has been shown to provide efficient filtration of inert particles larger and smaller than the nominal most-penetrating particle size (MPPS) range, 0.03-0.3 μm. Humans generate respiratory aerosols in the MPPS range, suggesting that short-range disease transmission could occur via small infectious particles. Data presented here show that the N95 FFR will afford a significant measure of protection against infectious particles as small as a bare H1N1 influenza virion, and that the capture mechanism does not discriminate in favor of, or against, biological particles.

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Multidisciplinary Approaches to Minimally Invasive Cancer Treatment Using Colloidal Iodine: Twelve Case Reports in Digestive System

Miura¹,

Wago²,

Fujiki³

2020

GJCCR

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Aerosol-phase activity of iodine captured from a triiodide resin filter on fine particles containing an infectious virus

Abstract: This study shows that disinfection by filter-bound iodine in the aerosol phase is too slow to be clinically significant in individual respiratory protection, but that it might be of benefit to limit airborne transmission of infections in enclosed areas.

Cited by 3 publications

References 17 publications

Antimicrobial Agent Treated Filtering Facepiece Respirators for Inactivation of Airborne Viruses During Environmental Catastrophe

Antimicrobial Agent Treated Filtering Facepiece Respirators for Inactivation of Airborne Viruses During Environmental Catastrophe

Capture of 0.1-μm aerosol particles containing viable H1N1 influenza virus by N95 filtering facepiece respirators

Multidisciplinary Approaches to Minimally Invasive Cancer Treatment Using Colloidal Iodine: Twelve Case Reports in Digestive System

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