Aerosolized Intraperitoneal Local Anesthetic for Laparoscopic Surgery: A Randomized, Double‐Blinded, Placebo‐Controlled Trial

Abstract

This study did not demonstrate a significant difference between TG and CG in the primary endpoint, pain at 6 h postoperatively.

Intraperitoneal ropivacaine and early postoperative pain and postsurgical outcomes after laparoscopic herniorrhaphy in toddlers: a randomized clinical trial

“…Intraperitoneal delivery of ropivacaine has also been reported to reduce postoperative pain and opioid analgesic requirements and our results are in agreement with this finding: as toddlers who received IPLA with ropivacaine, their FLACC score was significantly lower than of those in the control group 0–4 h after surgery. Intraperitoneal ropivacaine probably works through several pathways.…”

Peritoneal Nebulization of Ropivacaine during Laparoscopic Cholecystectomy: Dose Finding and Pharmacokinetic Study

“…Peritoneal nebulization of ropivacaine was associated with reduced morphine consumption when compared with both placebo and peritoneal instillation in different clinical scenarios [12–14]. Our data suggest lack of dose-dependent reduction on morphine requirements after surgery.…”

“…Nebulization of ropivacaine was associated with both statistical and clinical significant reduction of pain intensity after laparoscopic surgery when compared with nebulization of saline after laparoscopic surgery [12–14]. …”

“…The higher the local anesthetic concentration, the lower the nebulization time and consequently the lesser the “fog” in the abdominal cavity. We decided to use 50 mg as the minimum dose for this study because it is an in-between quantity of the doses used in our previous studies [12–14]. This initial dosage, proved to be effective, allowed for double the doses up to what we considered useful in clinical practice.…”

“…This method has shown great efficacy in the control of postoperative pain [7–12] and in the reduction of postoperative morphine consumption when compared with both placebo and peritoneal instillation in different clinical scenarios [12–14]. However, in all those studies there were patients experiencing residual pain and requiring significant amount of opioids.…”