2001
DOI: 10.1183/09031936.01.00070001
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Aerosolized PGE1, PGI2and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion

Abstract: High permeability oedema is an important feature in lung injury secondary to ischaemia-reperfusion. This study investigated the influence of aerosolized prostaglandin E1(PGE1), prostaglandin I2(PGI2) and the nitric oxide (NO)-donor, sodium nitroprusside (SNP) on microvascular barrier function in pulmonary ischaemia-reperfusion.Buffer-perfused rabbit lungs were exposed to 180 or 210 min of warm ischaemia while maintaining anoxic ventilation and a positive intravascular pressure.Reperfusion provoked a transient,… Show more

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Cited by 29 publications
(15 citation statements)
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“…This suggests a sustained beneficial effect on ventilation perfusion mismatch, which is well known to be an important component of pulmonary vascular disease (Agusti and Rodriguez-Roisin, 1993). Similar effects were observed after inhalation of various vasodilators such as nitric oxide, iloprost, and sodium nitroprusside (Demirakca et al, 1996;Olschewski et al, 1999;Schutte et al, 2001). The positive effect of ADM on pulmonary vascular resistance might be even enhanced or perpetuated by the improvement of oxygenation.…”
Section: Discussionsupporting
confidence: 50%
“…This suggests a sustained beneficial effect on ventilation perfusion mismatch, which is well known to be an important component of pulmonary vascular disease (Agusti and Rodriguez-Roisin, 1993). Similar effects were observed after inhalation of various vasodilators such as nitric oxide, iloprost, and sodium nitroprusside (Demirakca et al, 1996;Olschewski et al, 1999;Schutte et al, 2001). The positive effect of ADM on pulmonary vascular resistance might be even enhanced or perpetuated by the improvement of oxygenation.…”
Section: Discussionsupporting
confidence: 50%
“…52 In a rabbit model of warm ischemia-reperfusion injury, administration of aerosolized PGE 1 , PGI 2 or nitroprusside at the onset of ischemia resulted in a dramatic reduction in lung injury. 53 Low-dose PGI 2 administration in conjunction with Rolipram, a cAMP-specific phosphodiesterase inhibitor, also resulted in similar benefits, once again highlighting the central role of cAMP in attenuating lung injury. The requirement for administration before onset of ischemia suggests a possible role in donor management with these agents.…”
Section: Prostaglandinsmentioning
confidence: 66%
“…On the other hand, in a bufferperfused rabbit lung model of reperfusion injury, shortterm aerosolized PGI 2 at the beginning of ischemia suppresses the increase of the capillary filtration coefficient and progressive edema formation. In addition, the increase in pulmonary vascular resistance observed after reperfusion, mostly attributable to enhanced precapillary resistance, reflects an increase in TXA 2 production because it is suppressed by a TXA 2 receptor antagonist (Schü tte et al, 2001). Thus, PGI 2 has protective effects in ischemia/ reperfusion injury that may not be related to its vasodilator effects but mainly involve its anti-inflammatory effects, maintaining endothelial integrity and decreasing capillary permeability and edema.…”
Section: E the Prostacyclin Pathway And Ischemia/reperfusion Injurymentioning
confidence: 99%