The holistic approach is applied to several examples from the field of physics, engineering and systems engineering and its benefits are demonstrated. In all examples a holistic picture is used and studied while ignoring the various details of the discussed problems. Optimal control and optimal estimation approachs are used in the engineering examples. The results show that the holistic approach provides a deeper insight into the main phenomena while requiring much fewer computational resources Moreover, in all cases the details may significantly be changed yet leading to similar observed phenomena. Whenever applicable, the holistic approach is highly recommended.