Aerothionin, a Bromotyrosine Derivative with Antimycobacterial Activity from the Marine Sponge Aplysina gerardogreeni (Demospongia)

Encarnación-Dimayuga, Rosalba; Ramírez, Mario; Luna-Herrera, Julieta

doi:10.1076/phbi.41.5.384.15946

Cited by 32 publications

(23 citation statements)

References 5 publications

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“…Antibiotics, such as plakortin from Plakortis halichondroides (Higgs & Faulkner 1978), manoalide from Luffariella variabilis (De Silva & Scheuer 1980), furospongin-1 from Spongia officinalis (Anderson et al 1994) and aerothionin from Aplysina gerardogreeni (Encarnacion-Dimayuga et al 2003) have been isolated from marine sponges. These and other antibiotics isolated from marine sponges are active against human pathogens and other bacteria that are not found in the living environment of sponges.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and anti-diatom activity of Hong Kong sponges

Dobretsov¹,

Dahms²,

Qian³

2005

Aquat. Microb. Ecol.

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In this study, we link laboratory results with field evidence of microbial settlement responses to crude extracts of several sponge species from Hong Kong waters, including Callyspongia sp. 1, Callyspongia sp. 2, C. pulvinata, Mycale adhaerens, Haliclona cymaeformis var. 1, H. cymaeformis var. 2 and Halichondria sp. (Porifera: Demospongiae). Laboratory experiments showed that 6 out of 7 sponge extracts inhibited growth and caused mortality of the pennate diatom Nitzschia paleacea at tissue-level concentration. In disk-diffusion bioassays, extracts of the sponge Halichondria sp. inhibited the growth of 4 bacterial strains out of 11 isolated from inanimate substrata; other sponge extracts inhibited growth of only 1 or 2 bacterial strains. For field experiments, sponge metabolites were immobilized in a Phytagel ® matrix and exposed to natural microbial communities. After 2 d of exposure, bacterial densities on the gels with sponge extracts were lower than on control gels. Terminal restriction fragment length polymorphism (TRFLP) analysis of PCR-amplified bacterial community 16S rRNA genes obtained from these gels demonstrated that the communities were different between the sponge extracts and control gels. After 7 d of exposure, 6 (86%) extracts suppressed the recruitment of pennate diatoms and 3 (43%) sponge extracts suppressed the recruitment of bacteria. These results suggest that sponge extracts can modify the structure of bacterial communities and decrease the density of bacteria and diatoms in microfouling communities.

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Section: Introductionmentioning

confidence: 99%

Antibacterial and anti-diatom activity of Hong Kong sponges

Dobretsov¹,

Dahms²,

Qian³

2005

Aquat. Microb. Ecol.

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“…Deprotection of 7 with 10% HCl aq in MeOH to give purpurealidin E (2), followed by reductive N-methylation with NaBH(OAc) 3 and formalin into aplysamine-1 (3).…”

Section: Resultsmentioning

confidence: 99%

“…Bromotyrosine alkaloids, well known as one of biologically active substances, possess a wide range of biological activities including anti Human immunodeficiency virus 1 (HIV-1) activity, 1) anti methicillin-resistant Staphylococcus aureus (MRSA) activity, 2) anti multidrug-resistant Mycobacterium tuberculosis activity, 3) and anti-angiogenic activity. 4) Because of these interesting activities, a number of synthetic studies on these alkaloids have been reported.…”

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confidence: 99%

Total Synthesis of Dispyrin, Purpurealidin E, and Aplysamine-1

Yoshida

Yamaguchi

2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Bromotyrosine alkaloids, well known as one of biologically active substances, possess a wide range of biological activities including anti human immunodeficiency virus 1 (HIV-1) activity, 1) anti methicillin-resistant Staphylococcus aureus (MRSA) activity, 2) anti multidrug-resistant Mycobacterium tuberculosis activity, 3) and anti-angiogenic activity. 4) These are also known as therapeutically important G proteincoupled receptors, the histamine H 2 and H 3 receptors 5,6) and the adrenergic a 1D and a 2A receptors 6) antagonist.…”

Section: Notesmentioning

confidence: 99%