To evaluate the clinical effect of direct resin veneers and porcelain veneers in the esthetic restoration of anterior teeth affected by dental fluorosis, 64 patients suffering from dental fluorosis (328 teeth) between February 2015 and June 2016 were selected. Of these patients, 34 were given direct resin veneers (196 teeth) and 30 were given porcelain veneers (132 teeth). Clinical follow-up observation was carried out for 24 months on restoration integrity, marginal fit, gingival index, secondary caries, and patient satisfaction. After 24 months of restoration, it was found that there was no secondary caries in the direct resin veneer or porcelain veneer restoration, and the integrity of the restorations, marginal adhesiveness, and gingival condition examination scores were evaluated as excellent. The scores for patient satisfaction were 80.27 and 90.63, respectively, and the difference was statistically significant (p < 0.05). The results demonstrated that direct resin veneers and porcelain veneers can both achieve a positive clinical therapeutic effect in dental fluorosis esthetic restoration, but patient satisfaction after porcelain veneer restoration is higher.