Aetiological Characteristics of Infectious Diarrhea in Yantai City, Shandong Province, China in 2017

Sun, Zhenlu; Jin-jie, XU; Niu, Peihua; Jin, Miao; Gao, Qiao; Zhang, Ruiqing; Wang, Ji; Zhang, Yong

doi:10.3390/v14020216

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…The seasonal distribution of infectious diarrhea pathogens in 2018 and 2019 had a similar pattern to that of 2017 (9). Viral infections were distributed throughout the year, with peaks of rotavirus (RV) and astrovirus (Astv) infections mainly occurring in winter and spring, and no obvious seasonal pattern for enterovirus general (EV) and norovirus (G I and G II) infections.…”

Section: Seasonal Distribution Of the Ten Pathogens Causing Infectiou...mentioning

confidence: 78%

Pathogenetic characteristics of infectious diarrhea in Yantai City, Shandong Province, 2018–2019

Gao¹,

Hong

et al. 2023

Front. Public Health

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BackgroundAnalysis of the pathogenic spectrum, epidemiological characteristics and molecular epidemiological features of important pathogens of infectious diarrhea in Yantai City, Shandong Province, 2018–2019, were analyzed to provide a reference basis for the prevention and control of infectious diarrhea.MethodsA total of 1514 stool specimens were collected within 3 days of the onset of diarrhea in secondary or higher hospitals in Yantai from 2018–2019, and all specimens were tested for the presence of seven major viruses and three major bacteria by employing reverse transcription ploymeraer chain reaction (RT-PCR). Population and seasonal analyses were also performed on positive samples for infectious diarrhea. The top two ranked rotavirus and norovirus were focused on genotyping and analysis of geographical distribution.ResultsThe study showed that the high prevalence of infectious diarrhea in Yantai, Shandong Province, for two consecutive years in 2018 and 2019 was in young children aged 1–5 years, accounting for 48.6% of the total number of cases. Viral diarrhea was distributed throughout the year with no obvious seasonal distribution, while bacterial diarrhea was predominant in summer. Of 1514 stool specimens, the total positive rate of specimens was 43.92% (665/1514). One pathogen was detected in 507 specimens, two pathogens in 107 specimens, and three pathogens in 44 specimens, with mixed infections accounting for 22.71% of positive specimens (151/665). Viral diarrheal pathogens accounted for 93.23% (620/665) of positive samples. The percentages of positive samples for Rotavirus (RV), Norovirus GI, Norovirus GII, Enterovirus universal (EV), Enteroadenovirus (EAdV), Sapovirus (SaV), Astrovirus (Astv), Salmonella (SE), Listeria monocytogenes (LiMo), and Vibrio parahaemolyticus (VP) were 48.57%, 3.61%, 15.34%, and 10.68% of the total positive samples.ConclusionsThis study analyzed in detail the composition of infectious diarrhea pathogen spectrum, pathogen alternation pattern, seasonal distribution and population distribution of pathogens in Yantai City, Shandong Province, 2018–2019, to provide a basis for improving relevant local preventive measures and reducing the disease burden.

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Section: Seasonal Distribution Of the Ten Pathogens Causing Infectiou...mentioning

confidence: 78%

Pathogenetic characteristics of infectious diarrhea in Yantai City, Shandong Province, 2018–2019

Gao¹,

Hong

et al. 2023

Front. Public Health

Self Cite

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“…The most vulnerable population are children under 5 years of age. Although there are currently many studies that investigated the gastrointestinal pathogens in acute diarrhea ( 18 – 22 ) the related research in Zhangzhou city, Fujian province is still limited. Situated in the southeastern coastal area of China, Zhangzhou city experiences a distinct climate and environmental conditions that may influence the transmission and distribution of viral pathogens causing diarrheal diseases.…”

Section: Introductionmentioning

confidence: 99%

Etiological surveillance of viral diarrhea from 2017 to 2019 in Zhangzhou city, Fujian province, China

Guo,

Chen,

Wang

et al. 2024

Front. Public Health

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BackgroundViral diarrhea is one of the major causes of morbidity and mortality in children. This study aimed to conduct etiological surveillance of viral diarrhea in Zhangzhou city, Fujian province, China, from 2017 to 2019 to identify the prevalence, distribution, and characteristics of viral pathogens causing gastrointestinal infections in the region.MethodsStool samples were collected from patients with acute diarrhea in Zhangzhou city, Fujian province, China, from 2017 to 2019. Rotavirus, norovirus, astrovirus, and adenovirus were detected using fluorescence immunochromatography assay.ResultsOf the total 5,627 samples that were collected, at least one of the viruses (rotavirus, norovirus, astrovirus and adenovirus) was found to be positive in 1,422 samples. Rotavirus, norovirus, astrovirus, and adenovirus, were detected in 53.73, 16.68, 15.52, and 14.97%, respectively. Mixed infections were determined in 17.65% of the positive samples. The predominant mixed infections observed were a combination of norovirus and astrovirus, followed by rotavirus and norovirus, and rotavirus and astrovirus. The highest positive rate was observed in the 12–23-month group for rotavirus and adenovirus, while a significantly higher positive rate was observed for norovirus and astrovirus in the 6–11-month group.ConclusionThese findings from this etiological surveillance highlight the significant burden of viral diarrhea in Zhangzhou city, with rotavirus being the predominant pathogen. The identification of common mixed infections provides insights into the complex nature of viral diarrhea transmission. Target interventions and public health strategies should be implemented, particularly during the winter and spring seasons, to prevent and control the spread of viral pathogens causing gastrointestinal infections in this region.

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Correlation between serum vitamin D level and acute invasive enteritis in children

Yang,

Fang,

Zheng

et al. 2024

Immunity Inflam & Disease

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BackgroundDiarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1‐mediated intestinal inflammation. This study aimed to investigate the effects of serum vitamin D levels on acute invasive enteritis in children.MethodsThis prospective cohort study included 82 children aged 1–3 years with clinically diagnosed acute invasive enteritis at Sichuan Maternal and Child Health Hospital from February 2021 to February 2022, alongside a control group of 80 healthy children. Fecal specimens were collected for routine tests and occult blood analysis, while blood samples were taken for routine tests, C‐reactive protein, and 25‐OHD levels. Comparative analyses were performed between groups, and multifactorial logistic regression was used to identify factors influencing invasive enteritis.ResultsThe study group showed significantly lower serum 25‐OHD levels (27.95 ± 9.91 ng/mL) compared to controls (32.76 ± 10.23 ng/mL, p < .01). Among the study group, 19.5% (16/82) had levels <20 ng/mL, versus 12.5% (10/80) in controls. Regular vitamin D supplementation was lower in the study group (58.5% vs. 77.5%, p < .05). Outdoor activity duration was also reduced (2.57 ± 0.98 h vs. 3.04 ± 0.88 h, p < .01). Multivariate analysis identified that exclusive breastfeeding, greater outdoor activity time and regular vitamin D supplementation were all associated with reduced risk of invasive enteritis (p < .05).ConclusionThe findings indicate an association between low serum 25‐OHD levels and acute invasive enteritis in children aged 1‐3 years, suggesting that consistent vitamin D supplementation and sufficient outdoor activity may protect against this condition.

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Aetiological Characteristics of Infectious Diarrhea in Yantai City, Shandong Province, China in 2017

Cited by 5 publications

References 22 publications

Pathogenetic characteristics of infectious diarrhea in Yantai City, Shandong Province, 2018–2019

Pathogenetic characteristics of infectious diarrhea in Yantai City, Shandong Province, 2018–2019

Etiological surveillance of viral diarrhea from 2017 to 2019 in Zhangzhou city, Fujian province, China

Correlation between serum vitamin D level and acute invasive enteritis in children

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