Aetiological diagnosis of ischaemic stroke in young adults

Ferro, José M.; Massaro, Ayrton Roberto; Mas, Jean‐Louis

doi:10.1016/s1474-4422(10)70251-9

Cited by 239 publications

(200 citation statements)

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“…Few studies have shown the predominance of female in age group below 35, but no such study was reported in South Asian study. 10,11 Age limit of young stroke was found to vary with different studies, and usually below 45 or 50 years were specified in most literatures. Prevalence of stroke was found to be more in rural than urban area.…”

Section: Incidencementioning

confidence: 99%

“…63 Infectious diseases like meningitis, syphilis, malaria, borreliosis, varicella-zoster vasculopathy and cerebral vasculopathy due to human immunodeficiency virus are the well-known causes of stroke worldwide, but are unusual findings in most studies. 11,64,65 In a study of young Pakistani patients, infective meningitis was recognized as a major cause of stroke (34%) as shown in Table 3. 25 Tuberculous meningitis (TM) was diagnosed in 53% and bacterial meningitis in remaining patients which showed the higher prevalence of infectious diseases in Pakistan.…”

Section: Other Determined Etiologymentioning

confidence: 99%

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Young Ischemic Stroke in South Asia: A review

Ojha

Huang

et al. 2013

J Adv Intern Med

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Section: Incidencementioning

confidence: 99%

Section: Other Determined Etiologymentioning

confidence: 99%

Young Ischemic Stroke in South Asia: A review

Ojha

Huang

et al. 2013

J Adv Intern Med

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“…La enfermedad de pequeño vaso, la aterosclerosis de grandes vasos y la fibrilación auricular, que son responsables de la mayoría de los casos de ACV isquémico en pacientes de edad avanzada, son menos comunes en los adultos jóvenes (10)(11)(12) . Asimismo, son más frecuentes algunas etiologías como la disección arterial, estados protrombóticos, cardiopatías embolígenas diferentes a la fibrilación auricular (FA), entre otras, que si bien son responsable de la etiología del ACV en casos aislados, dado el pronóstico que conllevan y el eventual cambio en la conducta terapéutica, hacen imprescindible su búsqueda mediante un abordaje más exhaustivo (5,6,(10)(11)(12) .…”

Section: Introductionunclassified

“…Si bien es cierto que en este subtipo de ACV las etiologías son más diversas que en el ACV de los añosos, en los mayores de 35 años las etiologías se van asemejando a las del ACV de la población general (6,11,13) . Así mismo las hemorragias cerebrales presentan más variadas y distintas etiologías en este grupo y aumenta su proporción respecto a los ACV isquémicos (5,6) .…”

Section: Introductionunclassified

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Análisis de una Cohorte de Pacientes con ACV del Joven. Hospital de Clínicas, Montevideo.

Higgie

Urban

Hackembruch

et al. 2018

Rev. urug. med. interna

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Analysis of a cohort of patients with young man's stroke. Hospital of Clinics, Montevideo.Análise de uma coorte de pacientes com AVC do jovem. Hospital de Clínicas, Montevidéu.Resumen: Introducción. El ataque cerebro-vascular (ACV) es un importante problema de salud pública. Se define ACV en el joven a aquel que se presenta entre los 15-45 años. El objetivo primario de este trabajo es describir las características epidemiológicas, clínicas, imagenológicas, etiopatogénicas y terapéuticas de los pacientes con ACV en el joven. Materiales y Métodos. Se trata de un estudio retrospectivo y descriptivo, acerca de una cohorte de pacientes que presentaron ACV en el joven asistidos en el Hospital de Clínicas de Montevideo en el período comprendido entre junio de 2007 y junio de 2014. Resultados. Se incluyeron 50 pacientes que representaron el 5,6 % de todos los ACV en el período comprendido en el estudio. La media de edad fue de 33 años. En cuanto a la naturaleza, el 64% fueron isquémicos y el 36% hemorrágicos. Según la clasificación TOAST, la etiología más frecuente fue la criptogenética (34%). Respecto a la etiología de las hemorragias intracerebrales la mitad correspondió a malformaciones vasculares. Discusión. El porcentaje de ACV del joven fue algo menor que el descrito en otras comunicaciones. Comparado con el ACV en todas las edades, la hemorragia cerebral aumenta su proporción, si bien la naturaleza isquémica sigue predominando. La causa más frecuente de ACV isquémico del joven fue la criptogenética, seguida de la cardioembolia y las causas inhabituales. Las disecciones arteriales igualaron en prevalencia a la ateromatosis de grandes vasos. Este hecho es similar a lo descrito por la mayoría de los autores. Si bien la etiología más prevalente de hemorragia parenquimatosa fueron las malformaciones vasculares, la cantidad de hematomas hipertensivos no fue despreciable a estas edades.Palabras clave: Unidad ACV, ACV, joven.Abstract: Introduction. Stroke is an important public health issue. Stroke in the young is defined as the one who presents between 15 and 45 years old. The primary objective of this study is to describe the epidemiological, clinical, imaging, etiopathogenic and therapeutic characteristics of stroke in young patients. Materials and Methods. This was a retrospective and descriptive study of a cohort of patients who presented with stroke in the young assisted at the Hospital de Clínicas in Montevideo in the period between June 2007 and June 2014. Results. We have included fifty patients which accounted for 5.6% of all stroke in the period covered by the study. The mean age was 33 yo. As for nature, 64% were ischemic and 36% hemorrhagic. According to the TOAST classification, the most common etiology was cryptogenetic (34%). Regarding the etiology of intracerebral hemorrhages, half corresponded to vascular malformations. Discussion. The proportion of stroke in young people was somewhat lower than that described in other communications. Compared with stroke in all ages, cerebral hemorrhage increases its p...

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Prospective observational study of young adult ischemic stroke patients

et al. 2021

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Objective: Ischemic stroke (IS) in young patients may differ in etiology and prognosis from later-life IS, which is much more common. A number of single-center and population-based cohorts of affected individuals have been published, but information on the long-term prognosis of these patients is limited.Methods: IS patients (≤55 years), discharged over a 10-year period, were evaluated and prospectively followed. Subgroups were evaluated for type of stroke, antecedent risk factors (RF), long-term outcomes, and occupational status over several years of follow-up.Results: 178 IS individuals from 2001-2010 were divided into older (46-55, n = 118) and younger (18-45, n = 60) age groups. Traditional RF-hypertension, diabetes mellitus, hyperlipidemia-were significantly associated with IS, and increased with age. The distribution and type of IS were similar in both groups, except for an increase in small vessel IS among the older subgroup (p = .003).Of the evaluable patients at 5.1 ± 2.5 years of follow-up (n = 138), a similar proportion of patients in both subgroups had a recurrent IS, but no significant differences were found in most disability indices. Approximately one third of patients suffered from moderate to severe disability, and were unable to return to their prior work.Conclusions: Younger and older IS patients are generally predisposed from the same traditional RF which progress with age. Long-term disabilities tend to worsen over time due to recurrent vascular events. These data emphasize the need for a strategy for early identification of the already well-known stroke RF in younger stroke patients.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Aetiological diagnosis of ischaemic stroke in young adults

Cited by 239 publications

References 102 publications

Young Ischemic Stroke in South Asia: A review

Young Ischemic Stroke in South Asia: A review

Análisis de una Cohorte de Pacientes con ACV del Joven. Hospital de Clínicas, Montevideo.

Prospective observational study of young adult ischemic stroke patients

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