Aetiology and prevention of wound infection in appendicectomy

Gilmore, O. J. A.; Martin, T. D. M.

doi:10.1002/bjs.1800610407

Cited by 107 publications

(49 citation statements)

References 11 publications

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“…E. coli was the leading microorganism in the appendeceal lumen, and which translocate to MLN. In the literature, it has been reported that E. coli, and Streptococcus are the commonest organisms involved in an inflamed appendix [4,5,17]. The relationship between translocation and tissue injury score was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Does noncomplicated acute appendicitis cause bacterial translocation?

et al. 2007

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It is unknown whether noncomplicated acute appendicitis cause bacterial translocation. In this study, we aimed to test development of the bacterial translocation in the patients who were operated for acute appendicitis. In this prospective study, 10 control patients who underwent elective operations because of other reasons, and 18 patients with noncomplicated acute appendicitis were evaluated. No patients took prophylactic antibiotic. After laparotomy, samples were obtained from peritoneal leaf just close to wound edge, and peritoneal swab culture from right paracolic region. Before appendectomy, a mesenteric lymph node (MLN) adjacent to the terminal ileum was taken out. Tissue samples were placed in a sterile container for microbiological analysis, and 10% formalin for histopathological analysis. Control samples had no bacterial translocation. Only 3 of 18 (16.6%) patients with appendicitis included bacterial translocation to MLN. There was no significant difference between both groups. No bacterial colonization was detected in the peritoneal tissue and peritoneal swab culture. Peritoneal tissue injury score was 2 +/- 1.4 in controls and 2.8 +/- 1.7 in the patients with appendicitis (P>0.05). MLN injury score was 2.5 +/- 1.3 in controls and 3.2 +/- 1.5 in the patients with appendicitis (P>0.05). No patient developed wound and systemic infection. No significant bacterial translocation frequency and tissue injury score was identified in the children with noncomplicated acute appendicitis. This result suggests that antibiotic prophylaxis may be unnecessary in such patients.

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Section: Discussionmentioning

confidence: 99%

Does noncomplicated acute appendicitis cause bacterial translocation?

et al. 2007

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“…5,[9][10][11][12] Most authors have reported rates of about 5% for wound infection and 10% for postoperative intra-abdominal abscess. 5,[9][10][11][12][14][15][16][17][18] Although some reports (both adult and pediatric, often combined) indicate that some form of antibiotic prophylaxis will diminish the incidence of both complications, 35,[37][38][39][40][41][42][43][44][45][46][47][48][49][50] others claim it makes no difference. 5,23,24,[27][28][29][30][31][32][33]36,[51][52][53][54] In our series, each ruptured appendix at operation had an obvious perforation confirmed by histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

Open appendectomy for pediatric ruptured appendicitis: a historical clinical review of the prophylaxis of wound infection and postoperative intra-abdominal abscess

Ein

Nasr²,

Ein³

2013

Can J Surg

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“…The wound Penrose drain [3] or one half-inch gauze pack [4] and/or antibiotic powder [5][6][7][8][9][10][11][12] (ampicillin, 1977-1981; cefoxitin 1982-1995) were all placed in the subcutaneous space. If the infant or child was allergic to penicillin, no antibiotic powder was placed in the wound and intravenous clindamycin (or metronidazole) and gentamicin were used.…”

Section: Methodsmentioning

confidence: 99%