Aetiology and therapeutics of burning mouth syndrome: an update

Spanemberg, Juliana Cassol; Cherubini, Karen; Figueiredo, Maria Antonia Zancanaro de; Yurgel, Liliane Soares; Salum, Fernanda Gonçalves

doi:10.1111/j.1741-2358.2010.00384.x

Cited by 40 publications

(46 citation statements)

References 38 publications

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“…La situación hormonal puede estar implicada en una mayor prevalencia en las mujeres, quizás al modular otros factores de algún modo 1 . La muestra incluyó a población de Cataluña (cuya incidencia y prevalencia no habían sido publicadas anteriormente) y la edad media de los pacientes del grupo SBA fue de 60,4 años (rango, 22-97 años).…”

Section: Discussionunclassified

“…En ausencia de una lesión identificable, el malestar suele recurrir diariamente, aunque también se manifiestan períodos indoloros durante el día. Se produce principalmente en mujeres y afecta a su calidad de vida [1][2][3] .…”

Section: Introductionunclassified

“…En los últimos años las nuevas evidencias parecen vincular el SBA con las perturbaciones periféricas y neuropáticas 11,16 . La reducción hormonal en la menopausia se ha relacionado también con este síndrome 1,2,9 . Entre los factores sistémicos asociados al SBA se encuentran la diabetes mellitus 17 , el reflujo gastrointestinal 18 , las deficiencias nutricionales 17 , los cambios hormonales 9 y determinados efectos adversos de los fármacos 17 .…”

Section: Introductionunclassified

“…Sin embargo, en algunos pacientes es difícil identificar los factores etiológicos y en este caso el SBA se considera idiopático 1,11,16 . Ciertos pacientes refieren una mejoría con las bebidas frías, las comidas blandas y las actividades recreativas 3 .…”

Section: Introductionunclassified

“…En caso de que alguno de los anteriores fueran factores causales, el tratamiento de los mismos debería resolver la sensación de ardor. Para los casos idiopáticos, se han propuesto diversos tratamientos para mejorar el SBA, con resultados variables 1,14,25 .…”

Section: Introductionunclassified

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Síndrome de boca ardiente y factores asociados: estudio retrospectivo de casos y controles

et al. 2017

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Section: Discussionunclassified

Section: Introductionunclassified

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Síndrome de boca ardiente y factores asociados: estudio retrospectivo de casos y controles

et al. 2017

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Association Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease

Kim

et al. 2020

JAMA Otolaryngol Head Neck Surg

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Burning mouth syndrome is a chronic oral pain disorder that is characterized by a generalized or localized burning sensation without the presence of any specific mucosal lesions. It remains unclear, however, whether burning mouth syndrome is associated with the development of psychoneurological conditions among patients with the syndrome. OBJECTIVE To evaluate the risk of developing psychoneurological conditions, including depression, anxiety, dementia, and Parkinson disease, in patients with burning mouth syndrome. DESIGN, SETTING, AND PARTICIPANTSThis retrospective population-based cohort study was conducted using a nationwide representative cohort sample from the Korean National Health Insurance Service-National Sample Cohort, which consists of data from approximately 1 million patients in South Korea. The study included 586 patients with burning mouth syndrome (patient group) and 1172 individuals without burning mouth syndrome (comparison group). The patient group included all patients who received inpatient and outpatient care for an initial diagnosis of burning mouth syndrome between January 1, 2002, and December 31, 2012. The comparison group was selected (2 individuals without burning mouth syndrome for each patient with burning mouth syndrome) using propensity score matching for sex, age, location of residence, household income level, and comorbidities. Data were collected and analyzed from January 1, 2002, to December 31, 2013.MAIN OUTCOMES AND MEASURES Death and the incidence of psychopathological diseases. Affective disorder events that occurred among participants during the follow-up period were investigated using survival analysis, a log-rank test, and Cox proportional hazards regression models to estimate the incidence rates, survival rates, and hazard ratios, respectively, of participants who developed psychoneurological conditions. RESULTSOf 1758 total participants, 1086 (61.8%) were female; 701 participants (39.9%) were younger than 45 years, 667 (37.9%) were aged 45 to 64 years, and 390 (22.2%) were older than 64 years. The overall incidence of depression and anxiety was higher in patients with burning mouth syndrome (n = 586; 30.8 incidents and 44.2 incidents per 1000 person-years, respectively) than in individuals without burning mouth syndrome (n = 1172; 11.7 incidents and 19.0 incidents per 1000 person-years, respectively). The results also indicated a similar incidence of dementia and Parkinson disease between the patient group (6.5 incidents and 2.5 incidents per 1000 person-years, respectively) and the comparison group (4.9 incidents and 1.7 incidents per 1000 person-years, respectively). After adjusting for sociodemographic factors (age, location of residence, household income level, and comorbidities), the adjusted hazard ratios for the development of depression and anxiety among patients with burning mouth syndrome were 2.77 (95% CI, 2.22-3.45) and 2.42 (95% CI, 2.02-2.90), respectively. However, no association was found between burning mouth syndrome and the risk of developing dement...

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Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing

Martins

Silveira

Martins

et al. 2020

Journal of Biophotonics

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Emerging evidence indicates the clinical benefits of photobiomodulation therapy (PBMT) in the management of skin and mucosal wounds. Here, we decided to explore the effects of different regiments of PBMT on epithelial cells and stem cells, and the potential implications over the epigenetic circuitry during healing. Scratch‐wound migration, immunofluorescence (anti‐acetyl‐Histone H3, anti‐acetyl‐CBP/p300 and anti‐BMI1), nuclear morphometry and western blotting (anti‐Phospho‐S6, anti‐methyl‐CpG binding domain protein 2 [MBD2]) were performed. Epithelial stem cells were identified by the aldehyde dehydrogenase enzymatic levels and sphere‐forming assay. We observed that PBMT‐induced accelerated epithelial migration and chromatin relaxation along with increased levels of histones acetylation, the transcription cofactors CBP/p300 and mammalian target of rapamycin. We further observed a reduction of the transcription repression‐associated protein MBD2 and a reduced number of epithelial stem cells and spheres. In this study, we showed that PBMT could induce epigenetic modifications of epithelial cells and control stem cell fate, leading to an accelerated healing phenotype.

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Aetiology and therapeutics of burning mouth syndrome: an update

Cited by 40 publications

References 38 publications

Síndrome de boca ardiente y factores asociados: estudio retrospectivo de casos y controles

Síndrome de boca ardiente y factores asociados: estudio retrospectivo de casos y controles

Association Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease

Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing

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