Aetiology of bronchiectasis in <scp>G</scp>uangzhou, southern <scp>C</scp>hina

Guan, Weijun; Gao, Yonghua; Xu, Gang; Lin, Zhi-ya; Tang, Yan; Li, Huimin; Lin, Zhihua; Zheng, Jinping; Chen, Rongchang; Zhong, Nanshan

doi:10.1111/resp.12528

Cited by 81 publications

(82 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our cohort still represented characteristics of local bronchiectasis population33.We did not include longitudinal follow-up visits because some patients have been recruited for less than one year, therefore prognostic significance of LCI and MMEF remains unclear.It would be interesting to unravel the diagnostic performance of LCI and MMEF% predicted in mild bronchiectasis; however, we were unable to comment on this because healthy subjects have not been recruited for comparison in this study.LCI alone could not discriminate conductive or acinar ventilation heterogeneity. The sample size in certain subgroups (i.e.…”

Section: Discussionmentioning

confidence: 99%

Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis

Guan¹,

Yuan²,

Gao³

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

Little is known about the comparative diagnostic value of lung clearance index (LCI) and maximal mid-expiratory flow (MMEF) in bronchiectasis. We compared the diagnostic performance, correlation and concordance with clinical variables, and changes of LCI and MMEF% predicted during bronchiectasis exacerbations (BEs). Patients with stable bronchiectasis underwent history inquiry, chest high-resolution computed tomography (HRCT), multiple-breath nitrogen wash-out test, spirometry and sputum culture. Patients who experienced BEs underwent these measurements during onset of BEs and 1 week following antibiotics therapy. Sensitivity analyses were performed in mild, moderate and severe bronchiectasis. We recruited 110 bronchiectasis patients between March 2014 and September 2015. LCI demonstrated similar diagnostic value with MMEF% predicted in discriminating moderate-to-severe from mild bronchiectasis. LCI negatively correlated with MMEF% predicted. Both parameters had similar concordance in reflecting clinical characteristics of bronchiectasis and correlated significantly with forced expiratory flow in one second, age, HRCT score, Pseudomonas aeruginosa colonization, cystic bronchiectasis, ventilation heterogeneity and bilateral bronchiectasis. In exacerbation cohort (n = 22), changes in LCI and MMEF% predicted were equally minimal during BEs and following antibiotics therapy. In sensitivity analyses, both parameters had similar diagnostic value and correlation with clinical variables. MMEF% predicted is a surrogate of LCI for assessing bronchiectasis severity.

show abstract

Section: Discussionmentioning

confidence: 99%

Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis

Guan¹,

Yuan²,

Gao³

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bronchiectasis is considered as idiopathic after the exclusion of all known aetiologies. 1 However, although we do not want to criticize this important and considerable work, we nevertheless would like to mention that one possible cause has not been eliminated in this study, namely human leucocyte antigen (HLA) class I deficiency syndrome, which is in most cases the result of a defect either in one of the transporter associated with antigen processing (TAP1 or TAP2) genes or in the β2-microglobulin (β2m) gene. 2,3 In both situations, the expression level of HLA class I molecules at the cell surface is extremely low, 2,3 and at least in TAP deficiency most patients also have, in addition to necrotizing skin ulcers, chronic bacterial infections of the airways, which frequently evolve to bronchiectasis even at a young age.…”

Section: To the Editormentioning

confidence: 99%

“…1 The authors find that idiopathic, post-infectious and immunodeficiency-related causes are the most common origins of this syndrome. The idiopathic form is likewise a predominant aetiology in similar studies performed in other countries, as the authors well present.…”

Section: To the Editormentioning

confidence: 99%

“…The argument of the authors that cellular immunodeficiencies are complicated and costly 1 would not be so valid in this situation because it is cost-effective and easy to stain whole blood cells from patients with a fluorochrome-conjugated pan anti-HLA class I antibody, and then to analyse the expression level of HLA class I molecules by flow cytometry, in comparison with cells from a healthy control donor. Another alternative is serological HLA typing.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

HLA class I deficiency as an additional cause of bronchiectasis

Zimmer

Ollert

2015

Respirology

View full text Add to dashboard Cite

“…Despite identification of these key features on CT and extensive testing, no underlying aetiology is found in a large proportion of patients with bronchiectasis 46. The prevalence of idiopathic bronchiectasis varies amongst cohorts (32%‐66%) likely owing to geographic variations, diagnostic algorithms and other determinants 30, 47, 48, 49, 50, 51…”

Section: Diagnostic Approachmentioning

confidence: 99%

Suspecting non-cystic fibrosis bronchiectasis: What the busy primary care clinician needs to know

et al. 2017

View full text Add to dashboard Cite

SummaryAimsNon‐cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. In the last several decades, its prevalence has increased, making it likely to be encountered in the primary care setting. The aim was to review the clinical presentation and diagnosis of NCFB, with an emphasis on the role of computed tomography (CT).MethodsFor this review, trials and reports were identified from PubMed/Medline and ClinicalTrials.gov from the US NIH and the Cochrane Register of Controlled Trials. The search used keywords: bronchiectasis, non‐cystic fibrosis bronchiectasis, chronic pulmonary infection and computed tomography. No date/language restrictions were used.ResultsNon‐cystic fibrosis bronchiectasis often coexists with other respiratory conditions, such as chronic obstructive pulmonary disease. The prevalence of NCFB is increasing, particularly in women and older individuals, possibly as a result of increased physician awareness and widespread use of CT, which is the gold standard for the diagnosis of NCFB. CT can assist in identifying an underlying cause of NCFB and determining the extent and severity of the disease.DiscussionNon‐cystic fibrosis bronchiectasis should be suspected in the primary care setting in patients with chronic cough, purulent sputum and frequent respiratory infections that tend to resolve slowly or partially. Early diagnosis and determination of the extent and severity of the disease by CT and other tests are critical to establish therapy to improve quality of life and potentially slow progressive decline of lung function in patients with NCFB .

show abstract

Aetiology of bronchiectasis in Guangzhou, southern China

Cited by 81 publications

References 23 publications

Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis

Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis

HLA class I deficiency as an additional cause of bronchiectasis

Suspecting non-cystic fibrosis bronchiectasis: What the busy primary care clinician needs to know

Contact Info

Product

Resources

About