Aetiology of cirrhosis, hepatic fibrosis, and hepatocellular carcinoma.

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.

“…The present morphological study indicates that in the UK there is no connection between heterozygous Pi Z AAT deficiency and HCC. This finding is in contrast to other histological studies in the UK and USA (Palmer and Wolfe, 1976;Blenkinsopp and Haffenden, 1977) but confirms the work of Theodoropoulos et al (1976) and of Peters (1976).…”

“…A phenotyping study (Morin et al, 1975) and an investigation of AAT serum levels with selective phenotyping (Fisher et al, 1976) have shown no excess of Z heterozygotes in cirrhosis as compared with controls; but immunocytochemical and histological studies, using intracytoplasmic liver AAT globules as markers, have suggested that there is an association with cirrhosis (Eriksson et al, 1975;Blenkinsopp and Haffenden, 1977). Similar immunocytochemical studies have also indicated that there is an increased incidence of the Z allele in cases of hepatocellular carcinoma (Blenkinsopp and Haffenden, 1977;Palmer and Wolfe, 1976), but phenotyping studies have shown only a slight increase not reaching statistical significance (Peters, 1976) or no increase (Theodoropoulos et al, 1976). It has also been suggested that HCC may produce AAT globular inclusions (Palmer and Wolfe, 1976).…”

Hepatitis B surface antigen, hepatocellular carcinoma and cirrhosis in Hong Kong: a necropsy study: 1963-1976

“…Haemochromatosis was listed as an aetiological factor in 7-5°00 of the Glasgow cases and was exceptionally frequent (20%) in those of Johnson et al (1978), but it was rare both in the other London series (Blenkinsopp & Haffenden, 1977b) (Blenkinsopp & Haffenden, 1977b).…”

Congenital Deficiency of Alpha-1-Antitrypsin and Acute Viral Hepatitis in Infancy

“…Blenkinsopp and Hajfenden [5] have found HBsAg in 4 of 15 individuals affected by hepatic cirrhosis who showed storage of PAS+ DIAr material in the hepatic cells. Therefore, a pathogenetic role of the hepatitis B virus in this disease was hypothesized.…”