Aetiology of Congenital Talipes

Observations of Fetal Posture and Causal Mechanisms of Gongenital Deformity of Palate, Mandible, and Limbs

“…A great number of potentially teratogenic incidents arise in the first trimester of pregnancy, however, but normal babies are eventually delivered. The familial occurrence of cleft palate has a higher incidence than that for the population at large, but reports of a direct genetic background account for only 12 to 20 per cent of all cases. It is likely, therefore, that interaction between genes and environment, or environment alone, may be responsible for a considerable proportion of clefts of the palate.…”