Aetiology of Meningitis in Paediatric Age Group at a Tertiary Care Centre in Hyderabad, India - A Cross Sectional Study

Banu, Shaik Sumayyah; Madhuri, Sudha D; Reddy, Parupalli

doi:10.31080/asmi.2021.04.0961

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“…The institutional prevalence of bacterial meningitis in our tertiary care hospital was 3.37% which was low compared to with study conducted by Banu et al (2021) (7.5%). 12 On contrary, a higher prevalence of bacterial meningitis was reported in Indian studies conducted in Kolkata by Joardar et al (2012) (34.66%) and in Tamil Nadu by Minz et al (2008) (18.56%). 13,14 The lower incidence may be attributed to an improved vaccination coverage, and better social environment achieved over years.…”

Section: Discussionmentioning

confidence: 86%

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

Kamble

2023

Int J Contemp Pediatr

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Background: Bacterial meningitis is a significant cause of mortality and morbidity in children worldwide. C-reactive protein (CRP) raises rapidly in the first 24-48 hours of occurrence of bacterial meningitis and in large incremental increases thereafter. The present study was undertaken to find out the correlation between cerebrospinal fluid (CSF)-CRP and bacterial meningitis in paediatric age group. Methods: A total 123 children aged between 1 month to 12 years, in whom meningitis was suspected during the study period were included. Lumbar puncture performed at L3-L4 and CSF sample not more than 3 ml collected in 4 sterile containers. 1ml sent for protein and sugar, 0.5ml each sent for CSF cytology and CSF-CRP, 1ml sent for CSF culture sensitivity and gram staining. Results: The institutional incidence of bacterial meningitis was 3.37%. Fever (93.26%) and altered sensorium (92.30%), were the commonest symptoms and neck rigidity (58.65%) was the commonest meningeal sign. The neurologic assessment showed abnormal mental status (34.61%), abnormal cranial nerve findings (10.57%) and abnormal motor function (13.46%). The mean CRP level was 15.36±0.67 mg/l. Pneumococcus was the commonest isolated organism (53.48%) in CSF culture. The institutional mortality was 13.46%. CSF-CRP was positive in 104 (82.69%) of the culture-positive cases with a sensitivity of 82.69%, specificity 84.21%, positive predictive value 96.62% and negative predictive value of 47.05%. Conclusions: CRP levels in CSF offers a moderate sensitivity and specificity as well as high positive predictive value. This indicates that CSF-CRP is a better marker in differentiating bacterial meningitis and it can serve as a useful screening test for bacterial meningitis.

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Section: Discussionmentioning

confidence: 86%

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

Kamble

2023

Int J Contemp Pediatr

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Aetiology of Meningitis in Paediatric Age Group at a Tertiary Care Centre in Hyderabad, India - A Cross Sectional Study

Cited by 1 publication

References 0 publications

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

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