Aetiology of peptic ulcer: a prospective population study in Norway.

Johnsen, Roar; Førde, Olav Helge; Straume, Bjørn; Burhol, P. G.

doi:10.1136/jech.48.2.156

Cited by 46 publications

(32 citation statements)

References 26 publications

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“…Fermented milk has been shown to reduce gastric emptying, a fact that could be of importance for an antagonistic effect between lactic acid bacteria and H. Pylori (Strandhagen et al, 1994) The bactericidal effect of milk and colostrum disappeared after heating (Stro Èmqvist et al, 1995). This is consistent with ®ndings in this and other studies showing no positive effect of milk consumption on the occurrence of peptic ulcer (Johnsen et al, 1994;Mullan et al, 1994).…”

Section: Discussionsupporting

confidence: 82%

“…High intake of fermented milk was associated with fewer ulcers, whereas increased risk of peptic ulcer was observed among subjects with a high milk intake. The increased risk of peptic ulcer and milk intake is consistent with previous reports (Johnsen et al, 1994;Ippoliti et al, 1976). One explanation might be that milk and the high calcium content has a stimulative effect on acid secretion, although the intake of milk might reduce symptoms.…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Elmståhl¹,

Svensson²,

Berglund³

1998

Eur J Clin Nutr

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Background: Prevalence of peptic ulcer disease has been associated to diet. Some dietary factors seem to have bactericidal effect which may modify the risk of peptic ulcer disease. The objective was to analyze associations between dietary habits and peptic ulcers. Design: A cross sectional population study. Subjects: One thousand, one hundred and thirty-®ve subjects out of 11 700 randomly invited men and women, aged 46±67 y, participating in a diet and disease study during 1991±1993. The study population comprised of 764 cases with reported peptic ulcer, 142 with dyspeptic symptoms and 229 randomly selected controls. Methods: X-ray examinations and endoscopies were reviewed and 332 out of 764 peptic ulcer cases were veri®ed. Mean daily intake of foods and nutrients were assessed with a combined 7 d menu book and a quantitative food frequency questionnaire, including dietary supplements. Results: Subjects with veri®ed ulcer had lower intake of fermented milk products and vegetables and higher intake of milk, meat and bread than controls. Intake of total fat, saturated and monounsaturated fatty acids and linolenic acid were higher in the ulcer group. Higher intake of fermented milk products, by quintiles showed a decreased ulcer risk; odds ratio 0.82 (0.71±0.95), adjusted for covariates below. Higher intake of milk, by quintiles, was associated with an increased risk of ulcer; odds ratio 1.17 (1.03±1.32). Smoking, foreign ethnicity and being unmarried or divorced were covariates associated to ulcer. Conclusion: This study indicates the multifactorial etiology of peptic ulcer including dietary factors. High intake of fermented milk products was associated with decreased risk for ulcer, whereas increased risk was noted for high milk intake. Sponsorship: The study was supported by the Swedish Cancer Society.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 80%

Fermented milk products are associated to ulcer disease. Results from a cross-sectional population study

Elmståhl¹,

Svensson²,

Berglund³

1998

Eur J Clin Nutr

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“…Findings in a previous Norwegian study did not support the concept that peptic ulcer is a psychosomatic disorder [15] . However, childhood adversities have been found in association with other diseases, for example coronary heart disease [16] and migraine [17] , and also with disability pensions [18] .…”

Section: Discussioncontrasting

confidence: 48%

Reaching proficiency in laparoscopic splenectomy

Sumanen¹,

Koskenvuo²,

Sillanmäki³

et al. 2009

WJG

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AIM:To study the association between self-reported peptic ulcer and childhood adversities. METHODS:The Health and Social Support Study (HeSSup) population consisted of a stratified random sample drawn from the Finnish Population Register in four age groups: 20-24, 30-34, 40-44 and 50-54. The survey was carried out by postal questionnaire during 1998, with a response rate of 40.0%. A follow-up questionnaire was sent during 2003 to all those who responded to the first. Altogether 19 626 individuals returned the follow-up questionnaire; a response rate of 75.8%. The subjects were asked whether a doctor had told them that they have or have had peptic ulcer. The analyses covered those who responded affirmatively to both the baseline and the follow-up enquiries (n = 718). Those not reporting a peptic ulcer in either of the two questionnaires (n = 17 677) were taken as controls. The subjects were further requested (through six questions) to think about their childhood adversities. RESULTS:The most common adversities mentioned were long-lasting financial difficulties in the family, serious conflicts in the family, and a family member seriously or chronically ill. All the adversities reported, except parental divorce, were more common among peptic ulcer patients than among controls (P values varied between < 0.001 and 0.003). Age-and sexadjusted odds ratios (OR) of childhood adversities in the multivariate logistic analysis for self-reported peptic ulcer varied between 1.45 and 2.01. Adjusting for smoking, heavy drinking, stress and nonsteroidal antiinflammatory drug use had no further influence (ORs between 1.22 and 1.73). CONCLUSION:Our findings suggest that childhood adversities maintain a connection with and have a predictive role in the development of peptic ulcer.

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“…In contrast, a recently conducted retrospective observational study, 10 showed an association between psychological stress and PUD independent of other known risk factors (H. pylori infection and NSAID use). Johansen et al, 11 argued that some reports of associations between exposure to psychosocial stress and PUD may be unreliable, as both exposure and CI, confidence interval; HR, hazard ratio; n, number; SEI, socioeconomic index.…”

Section: Discussionmentioning

confidence: 99%

“…Stressful life events have been associated with increased PUD risk in some studies, 2, 7-10 but others did not find this. 5,6,[11][12][13] Earlier studies on the relationship between psychosocial stress and PUD have not been able to clearly identify that stressful exposures pre-dated disease onset. 2 As there is notable variation in stress susceptibility between individuals, 14,15 this characteristic prior to symptomatic onset of peptic ulcer may be a useful tool to elucidate the role of psychosocial stress as risk factor for PUD.…”

Section: Introductionmentioning

confidence: 99%