AEvit in complex treatment of acne patients

Dyudyun, A.D.; Поліон, Н.М.; Резніченко, Н.Ю.; Svyryd, S.G.; Горбунцов, В.В.

doi:10.30978/ujdvk2018-2-48

Cited by 2 publications

(11 citation statements)

References 8 publications

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“…53s The minimal lethal concentration of SEC for T. vaginalis is 56% lower than MTZ. 54s,55s In 2021, SEC received expanded approval for trichomoniasis in women, men, and adolescents 12 years or older based on data from a US-based RCT 23 and aggregate data from 4 non-US-based studies [24][25][26][27] (Table 1). The US-based trial in women was a randomized, double-blind, placebo-controlled, delayed-treatment study of SEC for trichomoniasis.…”

Section: Secnidazolementioning

confidence: 99%

“…Limitations included the use of culture to shorten time to TOC, lack of long-term follow-up, and failure to include men or pregnant women. Support for the SEC indication for T. vaginalis-infected men was based on 4 open-label, non-US-based trials [24][25][26][27] (Table 1). These studies included data on 211 men and 226 women who received SEC for trichomoniasis.…”

Section: Secnidazolementioning

confidence: 99%

“…21 A single 2-g oral dose of SEC was used in all 4 trials, but 1 trial also evaluated a multidose regimen of 2-g oral SEC taken 3 times for 5 days. 24 The fourth was a 3-arm trial in which men received a single 2-g dose of oral SEC, 250 mg of oral MTZ 3 times a day for 7 days, or 500 g of oral ORZ twice a day for 5 days. 25 In 3 trials including men and women, 24,26,27 microbiological cure rates by culture ranged from 91.7% to 97.7%, with an overall cure rate of 91.7% at 5 to 20 days after treatment.…”

Section: Secnidazolementioning

confidence: 99%

“…The most common AE in these trials was nausea (4%-9%). [24][25][26][27] In 1 study including only men, the cure rate was 100% (30 of 30) for SEC after 5 days of treatment. 25 Safety outcomes were not reported for this trial.…”

Section: Secnidazolementioning

confidence: 99%

“…and adolescents 12 years or older based on the results of an RCT in the United States 23 and trials conducted in Europe. [24][25][26][27] This approval came after the updated CDC and American College of Obstetricians and Gynecologists guidelines were written; however, SEC is in both guidelines as an alternative treatment for bacterial vaginosis (BV). 5,6 The use of multidose oral MTZ to treat trichomoniasis in women presents unique challenges for the management of male sexual partners.…”

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confidence: 99%

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Where do tinidazole and secnidazole fit in with the treatment of trichomoniasis?

Muzny

Kissinger

2023

Sexual Trans Dis

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T richomonas vaginalis is the most prevalent nonviral sexually transmitted infection (STI) worldwide, 1 affecting ~3.7 million individuals in the United States. 2 The prevalence is estimated to be 0.5% in men and 2.1% in women; rates are significantly higher in African American women (9.6%) versus Hispanic women (1.4%) and non-Hispanic White women (0.8%). 3,4 The true US prevalence is not known, as T. vaginalis is not reportable, and screening is only recommended in HIV-infected women. 5 Trichomoniasis is associated with multiple adverse health outcomes in women, including vaginitis, cervicitis, 6 cervical cancer, 7 pelvic inflammatory disease, 8,9 and adverse birth outcomes. 10,11 In men, it is associated with nongonococcal urethritis, 12,13 epididymitis, 14 prostatitis, and infertility. 15,16 It also is associated with HIVand other STIs in both sexes. 5,6,17 Despite its high prevalence and adverse outcomes, the significance of trichomoniasis is underappreciated in the medical community. [18][19][20] The 5-nitroimidazoles, including metronidazole (MTZ), tinidazole (TDZ), and secnidazole (SEC), are the only class of antimicrobial agents with confirmed effectiveness against T. vaginalis. 21 Until recently, the Centers for Disease Control and Prevention (CDC) STI Treatment Guidelines for trichomoniasis recommended a single 2-g dose of oral MTZ for HIV-negative women and men or, alternatively, a single 2-g dose of oral TDZ for women and men; multidose oral MTZ (500 mg twice daily for 7 days) was recommended for HIV-infected women. 5 In 2021, the CDC changed their treatment recommendation for all women with T. vaginalis to multidose oral MTZ, with single-dose 2-g oral TDZ remaining as an alternate. 5 This was in response to a randomized controlled trial (RCT) that found multidose oral MTZ to be superior to single-dose oral MTZ in HIV-negative women. 22 The American College of Obstetricians and Gynecologists updated their 2020 Clinical Management Guidelines in the same manner. 5,6 In contrast, a single 2-g dose of oral MTZ remains the recommended treatment for T. vaginalis-infected men, with a single 2-g dose of oral TDZ as an alternative. 5 Secnidazole, a next-generation 5-nitroimidazole with a longer half-life than MTZ or TDZ, 21 received Food and Drug Administration (FDA) approval for trichomoniasis in women, men,

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Section: Secnidazolementioning

confidence: 99%

Section: Secnidazolementioning

confidence: 99%

Section: Secnidazolementioning

confidence: 99%

Section: Secnidazolementioning

confidence: 99%

mentioning

confidence: 99%

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Where do tinidazole and secnidazole fit in with the treatment of trichomoniasis?

Muzny

Kissinger

2023

Sexual Trans Dis

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The effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms – the causative agents of pustular skin infections in the treatment of acne vulgaris (acne vulgaris)

2023

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The objective of the work was to study the effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, by comparing clinical data and the skin microbiome in patients with acne. The results of the study are based on the data of a comprehensive examination of 35 patients with acne of 2-3 degrees before and after treatment, as well as data of the examination of 15 patients of the control group. Examination methods: clinical examination of the skin, determination of the quantitative composition and microbiological identification of the skin microbiome (bacteria of the genera Staphylococcus, Streptococcus, Propionibacterium Corynebacterium, Micrococcus, Sarcina, Aerococcus, Acinetobacter, Brevibacterium, Citrobacter, Serratia, Lactobacillus; yeast-like fungi of the genera Malassesia and Candida, mold fungi ). In the studied patients with acne, the representative microorganisms of the skin microbiome were Propionibacterium acnes, S. epidermidis, and C. lipophilicum. In patients with acne, the stability of the skin microbiome was carried out due to the redistribution between S. epidermidis and C. lipophilicum. In patients receiving "Acnevac"® (Bioveta, a. s.), a component of a complex treatment, along with earlier periods of clinical improvement, there was noted an earlier normalization of the skin microbiome in comparison with patients receiving standard therapy. Approaches to the treatment of acne with antibiotics and chemotherapy require a revision. The state of the skin microbiome broadens knowledge on the pathogenesis of acne and the search for other means for the individual treatment of patients. Positive changes in the skin microbiome under the influence of treatment with purified bacterial lysates of the most therapy-resistant strains of microorganisms, the causative agents of pustular skin infections, make it possible to recommend its use for a longer term – up to 6 months.

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AEvit in complex treatment of acne patients

Cited by 2 publications

References 8 publications

Where do tinidazole and secnidazole fit in with the treatment of trichomoniasis?

Where do tinidazole and secnidazole fit in with the treatment of trichomoniasis?

The effectiveness of the use of purified bacterial lysates of the most therapy-resistant strains of microorganisms – the causative agents of pustular skin infections in the treatment of acne vulgaris (acne vulgaris)

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