Afectación del aparato digestivo en la covid-19. Una revisión sobre el tema

Segura, Patricia; Lázaro, Yolanda Arguedas; Tapia, Sonia Mostacero; Chaves, Tomás Cabrera; Domingo, Juan José Sebastián

doi:10.1016/j.gastrohep.2020.06.004

Cited by 14 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On October 6, 2020 searching on PubMed "COVID-19 OR COVID-2019 OR severe acute respiratory syndrome coronavirus 2 OR severe acute respiratory syndrome coronavirus 2 OR 2019-nCoV OR SARS-CoV-2 OR 2019nCoV OR (Wuhan AND coronavirus) AND liver" we found 1,319 papers. Several data reported that approximately half of SARS-CoV-2 patients show liver biochemistry abnormalities, with increased levels of aminotransferases, gamma-glutamyl transferase, bilirubin, and alkaline phosphatase (116,(211)(212)(213)(214)(215)(216)(217)(218). Median aspartate aminotransferase-dominant aminotransferase increase seems to indicate the disease severity and seems to be an index of hepatic injury (211).…”

Section: Livermentioning

confidence: 99%

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV-2 must bind the ACE2 for entering the host cells in humans, its expression and body localization are critical to track the potential target organ of this infection and to outline disease progression and clinical outcomes. Here, we mapped the physiological body distribution, expression, and activities of ACE2 and discussed its potential correlations and mutal interactions with the disparate symptoms present in SARS-CoV-2 patients at the level of different organs. We highlighted that despite during SARS-CoV-2 infection ACE2-expressing organs may become direct targets, leading to severe pathological manifestations, and subsequent multiple organ failures, the exact mechanism and the potential interactions through which ACE2 acts in these organs is still heavily debated. Further scientific efforts, also considering a personalized approach aimed to consider specific patient differences in the mutual interactions ACE2-SARS-CoV-2 and the long-term health effects associated with COVID-19 are currently mandatory.

show abstract

Section: Livermentioning

confidence: 99%

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These studies demonstrated the presence of SARS-CoV-2 in the gastrointestinal tract of COVID-19 patients, which means that gastrointestinal symptoms could be correlated with viral infections in patients with COVID-19. In nearly half of the COVID-19 patients with digestive symptoms, viral RNA can be detected in their stool for determining the diagnosis and transmission [ 12 ]. The possibility of faecal–oral transmission of SARS-CoV-2 has important implications and needs further study.…”

Section: Gastrointestinal Tract Involvement In Covid-19 Patientsmentioning

confidence: 99%

Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver

Lei

Ding

Nie

et al. 2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.

show abstract

“…In particular, studies involving immunofluorescence techniques showed that this protein is largely expressed in gastric, duodenal, and rectal epithelial glandular cells, representing a possible gateway for SARS-CoV-2 [ 11 ]. In this context, SARS-CoV-2 could be responsible for gastrointestinal inflammation [ 12 ] leading to malabsorption, intestinal disorders, activation of the enteric nervous system, and, ultimately, diarrhea.…”

Section: Sars-cov-2 and Gut: An Undervalued Relationshipmentioning

confidence: 99%

Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection

et al. 2021

View full text Add to dashboard Cite

Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host’s microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response (“gut-lung axis”). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia.

show abstract

Afectación del aparato digestivo en la covid-19. Una revisión sobre el tema

Cited by 14 publications

References 41 publications

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver

Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection

Contact Info

Product

Resources

About