Affected inflammation-related signaling pathways in snake envenomation: A recent insight

Luo, Peiyi; Ji, Yuxin; Liu, Xiaohan; Zhang, Weiyun; Cheng, Ruoxi; Zhang, Shuxian; Qian, Xiao; Huang, Chunhong

doi:10.1016/j.toxicon.2023.107288

Toxicon

2023

DOI: 10.1016/j.toxicon.2023.107288

|View full text |Cite

Affected inflammation-related signaling pathways in snake envenomation: A recent insight

Peiyi Luo,

Yuxin Ji,

Xiaohan Liu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations

Lafnoune,

Chbel,

Darkaoui

et al. 2024

Int J Pept Res Ther

View full text Add to dashboard Cite

Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations

Lafnoune,

Chbel,

Darkaoui

et al. 2024

Int J Pept Res Ther

View full text Add to dashboard Cite

Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA2

Zhao,

Liu,

Wang

et al. 2024

Toxicon

View full text Add to dashboard Cite

Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells

Cheng,

Di,

et al. 2024

IJMS

View full text Add to dashboard Cite

UVB radiation is known to induce photodamage to the skin, disrupt the skin barrier, elicit cutaneous inflammation, and accelerate the aging process. Agaricus blazei Murill (ABM) is an edible medicinal and nutritional fungus. One of its constituents, Agaricus blazei Murill polysaccharide (ABP), has been reported to exhibit antioxidant, anti-inflammatory, anti-tumor, and immunomodulatory effects, which suggests potential effects that protect against photodamage. In this study, a UVB-induced photodamage HaCaT model was established to investigate the potential reparative effects of ABP and its two constituents (A1 and A2). Firstly, two purified polysaccharides, A1 and A2, were obtained by DEAE-52 cellulose column chromatography, and their physical properties and chemical structures were studied. A1 and A2 exhibited a network-like microstructure, with molecular weights of 1.5 × 104 Da and 6.5 × 104 Da, respectively. The effects of A1 and A2 on cell proliferation, the mitochondrial membrane potential, and inflammatory factors were also explored. The results show that A1 and A2 significantly promoted cell proliferation, enhanced the mitochondrial membrane potential, suppressed the expression of inflammatory factors interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), and increased the relative content of filaggrin (FLG) and aquaporin-3 (AQP3). The down-regulated JAK-STAT signaling pathway was found to play a role in the response to photodamage. These findings underscore the potential of ABP to ameliorate UVB-induced skin damage.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Affected inflammation-related signaling pathways in snake envenomation: A recent insight

Cited by 4 publications

References 110 publications

Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations

Cobra Venom: From Envenomation Syndromes to Therapeutic Innovations

Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA2

Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells

Contact Info

Product

Resources

About