Affective Disorder and Hyperandrogenism

Zerouni, Celen; Kummerow, Elaine; Martinez, Mariflor; Díaz, Ana García; Ezequiel, Uribe; Wix-Ramos, R.

doi:10.2174/1872214811307010077

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…In line with this and with the reduction of androgen levels seen in domestication, BD is associated with decreased testosterone levels among untreated first‐episode patients (Feng et al, 2019) and remitted male patients (Keshri et al, 2018). Interestingly, in BD patients in a current depressive episode, testosterone levels were significantly decreased among male patients compared with healthy male controls and significantly increased among female patients compared with healthy female controls (Wooderson et al, 2015), consistent with findings of hyperandrogenemia in women with BD (Rasgon et al, 2005; Zerouni et al, 2013). In both males and females with BD (and controlling for sex), testosterone levels positively correlated with number of manic episodes as well as number of suicide attempts (with no correlation found between testosterone levels and aggression) (Sher et al, 2012).…”

Section: Resultssupporting

confidence: 63%

Abnormal features of human self‐domestication in bipolar disorder

Benítez‐Burraco

Hansen

2023

Eur J of Neuroscience

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Bipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, although it is not still clear how genes contribute to the onset and course of the disease. In this paper, we adopted an evolutionary‐genomic approach to this condition, focusing on changes occurred during human evolution as a source of our distinctive cognitive and behavioural phenotype. We show clinical evidence that the BD phenotype can be construed as an abnormal presentation of the human self‐domestication phenotype. We further demonstrate that candidate genes for BD significantly overlap with candidates for mammal domestication and that this common set of genes is enriched in functions that are important for the BD phenotype, especially neurotransmitter homeostasis. Finally, we show that candidates for domestication are differentially expressed in brain regions involved in BD pathology, particularly, the hippocampus and the prefrontal cortex, which have been subject to recent changes in our species. Overall, this link between human self‐domestication and BD should facilitate a better understanding of the BD etiopathology.

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