Affective disorders and other psychiatric diagnoses in children and adolescents with 22q11.2 Deletion Syndrome

Jolin, Edith M.; Weller, Ronald A.; Jessani, Naushad; Zackai, Elaine H.; McDonald‐McGinn, Donna M.; Weller, Elizabeth B.

doi:10.1016/j.jad.2009.02.016

Cited by 41 publications

(43 citation statements)

References 17 publications

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“…The prevalence of bipolar disorders does not appear to be higher in individuals with 22q11.2 deletion syndrome than in the general population, a pattern consistent with findings in previous smaller studies (6, 8, 14, 15, 19). It does contrast with very early reports of the psychiatric phenotype in 22q11.2 deletion syndrome, which indicated bipolar disorders in small cohorts (7, 53).…”

Section: Discussionsupporting

confidence: 89%

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

Schneider

Debbané

Bassett

et al. 2014

AJP

Self Cite

699

740

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Objective Chromosome 22q11.2 deletion syndrome is a neurogenetic disorder associated with high rates of schizophrenia and other psychiatric conditions. The authors report what is to their knowledge the first large-scale collaborative study of rates and sex distributions of psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome. The associations among psychopathology, intellect, and functioning were examined in a subgroup of participants. Method The 1,402 participants with 22q11.2 deletion syndrome, ages 6–68 years, were assessed for psychiatric disorders with validated diagnostic instruments. Data on intelligence and adaptive functioning were available for 183 participants ages 6 to 24 years. Results Attention deficit hyperactivity disorder (ADHD) was the most frequent disorder in children (37.10%) and was overrepresented in males. Anxiety disorders were more prevalent than mood disorders at all ages, but especially in children and adolescents. Anxiety and unipolar mood disorders were overrepresented in females. Psychotic disorders were present in 41% of adults over age 25. Males did not predominate in psychotic or autism spectrum disorders. Hierarchical regressions in the subgroup revealed that daily living skills were predicted by the presence of anxiety disorders. Psychopathology was not associated with communication or socialization skills. Conclusions To the authors' knowledge, this is the largest study of psychiatric morbidity in 22q11.2 deletion syndrome. It validates previous findings that this condition is one of the strongest risk factors for psychosis. Anxiety and developmental disorders were also prevalent. These results highlight the need to monitor and reduce the long-term burden of psychopathology in 22q11.2 deletion syndrome.

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Section: Discussionsupporting

confidence: 89%

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

Schneider

Debbané

Bassett

et al. 2014

AJP

Self Cite

699

740

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“…At least one psychiatric disorder is diagnosed in 73–90% of individuals with 22q11DS (Green et al 2009; Stoddard et al 2010; Jolin et al 2012). ADHD and anxiety disorders are common, with 35–55% of individuals diagnosed with ADHD, 15–27% with generalized anxiety disorder (GAD), 3–10% with obsessive–compulsive disorder (OCD), 5–8% with separation anxiety and 17– 46% with specific phobias (Green et al 2009; Jolin et al 2009, 2012; Niklasson et al 2009; Antshel et al 2010; Stoddard et al 2010; Fabbro et al 2012). Mood disorders are present in 13–64%, predominantly represented by major depressive disorder (MDD) (Jolin et al 2009; Antshel et al 2010; Stoddard et al 2010; Fabbro et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…ADHD and anxiety disorders are common, with 35–55% of individuals diagnosed with ADHD, 15–27% with generalized anxiety disorder (GAD), 3–10% with obsessive–compulsive disorder (OCD), 5–8% with separation anxiety and 17– 46% with specific phobias (Green et al 2009; Jolin et al 2009, 2012; Niklasson et al 2009; Antshel et al 2010; Stoddard et al 2010; Fabbro et al 2012). Mood disorders are present in 13–64%, predominantly represented by major depressive disorder (MDD) (Jolin et al 2009; Antshel et al 2010; Stoddard et al 2010; Fabbro et al 2012). Perhaps most remarkably, psychotic disorders are diagnosed in 23–32% of adults with 22q11DS (Murphy et al 1999; Gothelf et al 2007; Bassett & Chow, 2008; Green et al 2009; Schreiner et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated

et al. 2013

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Background Chromosome 22q11.2 deletion syndrome (22q11DS) is a common genetic disorder with high rates of psychosis and other psychopathologies, but few studies discuss treatment. Our aim was to characterize the prevalence and treatment of major psychiatric illnesses in a well-characterized sample of individuals with 22q11DS. Method This was a cross-sectional study of 112 individuals aged 8 to 45 years with a confirmed diagnosis of 22q11DS. Each participant was administered a modified Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) and the Structured Interview for Prodromal Syndromes (SIPS). Phenotypes assessed were threshold and subthreshold psychosis, depression, mania, generalized and separation anxiety, obsessions/compulsions, inattention/hyperactivity and substance use. Histories of mental health care and current psychotropic treatment were obtained. Results Psychopathology was common, with 79% of individuals meeting diagnostic criteria for a disorder at the time of assessment. Diagnoses of psychosis were made in 11% of cases, attenuated positive symptom syndrome (APS) in 21%, and 47% experienced significant subthreshold symptoms. Peak occurrence of psychosis risk was during adolescence (62% of those aged 12–17 years). Criteria for a mood disorder were met by 14%, for anxiety disorder 34% and for attention deficit hyperactivity disorder (ADHD) 31%. Mental health care had been received by 63% of individuals in their lifetime, but only 40% continued therapy and 39% used psychotropics. Antipsychotics were used by 42% of participants with psychosis and none of the participants with APS. Half of those at risk for psychosis were receiving no mental health care. Conclusions Psychopathology is common in 22q11DS but is not adequately treated or clinically followed. Particular attention should be paid to subthreshold psychotic symptoms, especially in adolescents.

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“…Depression and anxiety disorders in children have recently aroused great interest among researchers in the field of velo-cardio-facial syndrome [1][2][3][4][5]. These pathologies are highly prevalent, can have a dramatic impact on the daily lives of patients and their families and can affect future development.…”

Section: Introductionmentioning

confidence: 99%

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Fabbro

Rizzi

Schneider

et al. 2012

Eur Child Adolesc Psychiatry

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Velo-cardio-facial syndrome (VCFS) is characterized by a high prevalence of depression and anxiety disorders in childhood and adolescence. These disorders are a source of great impairment in everyday functioning, as well as important risk factors for the emergence of later psychotic disorders. Impairment in daily and social functioning as well as loss of IQ throughout growth are also are well-established correlates of the VCFS. This study aimed to confirm the high prevalence of depression and anxiety disorders. The second objective was to ascertain the correlation between anxious and depressive symptoms and the decline in adaptive and cognitive functioning. A total of 73 children and adolescents with VCFS (mean age 11.9 years) underwent psychiatric evaluation. Subjects were further divided into four age groups: ages 6-9, 9-12, 12-15 and 15-18 years. Assessments measuring intelligence, anxious and depressive symptoms, and adaptation skills reported by parents were submitted to a subsample of 62 children (mean age 12.2 years); 62.2 % of the sample showed an anxiety disorder, specific phobia being the most represented at all ages. Lifetime depression concerned 27 % of the sample, peaking at age 12-15 years. Anxious and depressive symptoms and low IQ were significantly associated with low adaptive functioning. Anxiety and depression are common disorders in children and adolescents with VCFS and have a great impact on adaptive functioning. Clinicians should pay great attention to diagnosis and treatment.

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Affective disorders and other psychiatric diagnoses in children and adolescents with 22q11.2 Deletion Syndrome

Cited by 41 publications

References 17 publications

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

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