Affective Disturbances Modulate the Neural Processing of Visceral Pain Stimuli in Irritable Bowel Syndrome: An fMRI Study

Elsenbruch, Sigrid; Rosenberger, Christina; Schedlowski, Manfred; Forsting, Michael; Gizewski, Elke R.

doi:10.1055/s-0029-1208157

Cited by 40 publications

(76 citation statements)

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“…One of the mechanisms proposed to explain this association in functional dyspepsia is visceral hypersensitivity, that is, an increased perception of gastrointestinal sensations (27,28). It was demonstrated that anxiety and depression may influence the central processing of visceral stimuli, increasing the perception of gastrointestinal sensations (29). Gastrointestinal symptoms, on their turn, may increase the levels of anxiety and depression, leading to a vicious cycle.…”

Section: Discussionmentioning

confidence: 99%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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Objectives: To evaluate, in a group of patients with long-standing type 1 diabetes (DM1), an association of dyspepsia symptoms with: changes in the gastroduodenal mucosa, infection by Helicobacter pylori, glycemic control, and psychological and nutritional factors. Subjects and methods: A total of 32 patient with DM1 were studied (age: 38 ± 9 years; females: 25; diabetes duration: 22 ± 5 years). All patients answered a standardized questionnaire for the evaluation of gastrointestinal symptoms and underwent upper gastrointestinal endoscopy, with gastric biopsies for the evaluation of Helicobacter pylori infection. The presence of anxiety and depression was evaluated by the HAD scale. Nutritional parameters were BMI, arm and waist circumference, skinfold measurement, and body fat percentage. Results: Upper endoscopy detected lesions in the gastric mucosa in 34.4% of the patients, with similar frequency in those with (n = 21) and without dyspepsia (n = 11). The patients with dyspepsia complaints showed greater frequency of depression (60% vs. 0%; p = 0.001), higher values for HbA1c (9.6 ± 1.7 vs. 8.2 ± 1.3%; p = 0.01) and lower values for BMI (24.3 ± 4.1 vs. 27.2 ± 2.6 kg/m 2 ; p = 0.02), body fat percentage (26.6 ± 6.2 vs. 30.8 ± 7.7%; p = 0.04), and waist circumference (78.7 ± 8 vs. 85.8 ± 8.1 cm; p = 0.02). No association was found between the symptoms and the presence of Helicobacter pylori. Conclusions: Dyspepsia symptoms in patients with long-standing DM1 were associated with glycemic control and depression, and they seem to negatively influence the nutritional status of these patients. Arch Endocrinol Metab. 2015;59(2):129-36

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Section: Discussionmentioning

confidence: 99%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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“…In a model of visceral pain induction such as inflating a balloon into the rectum, an activation of the amygdala is observed in healthy volunteers (Baciu, et al 1999) while aberrant functional responses (e.g. deactivation of the amygdala) to noxious rectal stimulation was observed in areas of the brain involved in emotional sensory processing, particularly the amygdala, insula, and prefrontal cortex in IBS patients (Bonaz, et al 2002;Elsenbruch, et al 2010;Tillisch, et al 2011) thus arguing for an abnormal brain processing of visceral pain following rectal distension. Activation of corticosteroid receptor (both glucocorticoid and mineralocorticoid receptors) in the CeA is involved in the induction of anxiety and visceral hypersensitivity (Myers and Greenwood-Van Meerveld 2007b).…”

Section: Amygdala and Visceral Hyperalgesiamentioning

confidence: 99%

“…Patients with IBS exhibit enhanced perception of visceral sensation to colonic distension which is associated with hypervigilance at the origin of visceral hypersensitivity (VHS) (Ritchie 1973;Bradette, et al 1994;Elsenbruch, et al 2010). VHS is a clinical marker of IBS considered to play a major role in its pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Bonaz¹,

Pellissier²,

Sinniger³

et al. 2012

The Amygdala - A Discrete Multitasking Manager

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“…For example, the activation map following rectal balloon distention can indicate the altered neural processing of visceral pain in the somatosensory cortex, frontal cortex, cingulate cortex, insula, thalamus, and (pre)motor cortex with higher pain sensation (visceral hypersensitivity) in patients than in controls. 15,17 Anxiety and depression were associated with the brain activation in the cingulate cortex and prefrontal cortex, 28 and history of abuse affected the brain activation in the cingulate cortex. 27 Several studies have attempted to identify the specific mechanisms of treatment 86 and neuroimaging biomarkers for further disorders.…”

Section: Interpreting Functional Magnetic Resonance Imaging Results Imentioning

confidence: 99%

“…34 Furthermore, correlation analysis between fMRI data and psychological indices such as anxiety and depression may demonstrate the influence of the psychological state on patients. 28,35 When interpreting the fMRI results on interventions, the blinding issue, changes of symptoms, co-morbidities, quality of life, non-specific effect, and placebo response should also be taken into consideration carefully.…”

Section: Interpreting Functional Magnetic Resonance Imaging Results Imentioning

confidence: 99%

How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

Lee

Preißl

Enck

2017

J Neurogastroenterol Motil

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Functional neuroimaging studies have revealed the importance of the role of cognitive and psychological factors and the dysregulation of the brain-gut axis in functional gastrointestinal disorder patients. Although only a small number of neuroimaging studies have been conducted in functional gastrointestinal disorder patients, and despite the fact that the neuroimaging technique requires a high level of knowledge, the technique still has a great deal of potential. The application of functional magnetic resonance imaging (fMRI) technique in functional gastrointestinal disorders should provide novel methods of diagnosing and treating patients. In this review, basic knowledge and technical/practical issues of fMRI will be introduced to clinicians.

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Affective Disturbances Modulate the Neural Processing of Visceral Pain Stimuli in Irritable Bowel Syndrome: An fMRI Study

Cited by 40 publications

References 0 publications

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders

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