Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity

Hallihan, Hagar; Tsai, Perry; Lv, Nan; Xiao, Lan; Bernabé, Beatriz Peñalver; Wu, Yichao; Pandey, Ghanshyam N.; Williams, Leanne M.; Ajilore, Olusola; Ma, Jun

doi:10.1016/j.jpsychires.2023.01.044

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…Recent studies by Hallihan et al have found that affective neural circuits and inflammatory markers are associated with symptoms of depression and anxiety in comorbidities of obesity [ 139 ]. They used the current feasibility study using functional neuroimaging and biospecimen data to identify whether changes in inflammatory markers, fecal short-chain fatty acids, as well as neural circuit-based targets predicted depression and anxiety outcomes in comorbid obese participants, and preliminary correlation analyses showed significant correlated changes in three inflammatory markers (IL-1RA, IL-6, and TNF-α) and five neural targets (negative influence circuit, positive influence circuit, and default mode circuit) at 2 months [ 139 ].…”

Section: Shared Biological Mechanisms Of Depression and Obesitymentioning

confidence: 99%

“…They used the current feasibility study using functional neuroimaging and biospecimen data to identify whether changes in inflammatory markers, fecal short-chain fatty acids, as well as neural circuit-based targets predicted depression and anxiety outcomes in comorbid obese participants, and preliminary correlation analyses showed significant correlated changes in three inflammatory markers (IL-1RA, IL-6, and TNF-α) and five neural targets (negative influence circuit, positive influence circuit, and default mode circuit) at 2 months [ 139 ]. Further, they found that changes in IL-1RA and TNF-α at 2 months, as well as changes in three neural targets (negative influence circuit and positive influence circuit), correlated with changes in depression and anxiety symptoms at 6 months [ 139 ]. Perinatal exposure to maternal obesity, metabolic disorders (including diabetes and hypertension), and unhealthy maternal diets have long-term effects on the behavior and physiology of offspring [ 123 ].…”

Section: Shared Biological Mechanisms Of Depression and Obesitymentioning

confidence: 99%

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Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Wang

Zhao

et al. 2023

Aging

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Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exacerbate metabolic and related depressive symptoms. However, the neural mechanism under the mutual control of obesity and depression is largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain the in vivo homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytokines and lipokines. In addition, the review summarizes potential and future treatments for obesity and depression and raises several questions that need to be answered in future research. This review will provide a comprehensive description and localization of the biological connection between obesity and depression to better understand the co-morbidity of obesity and depression.

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Section: Shared Biological Mechanisms Of Depression and Obesitymentioning

confidence: 99%

Section: Shared Biological Mechanisms Of Depression and Obesitymentioning

confidence: 99%

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Wang

Zhao

et al. 2023

Aging

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Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies

Chang,

Jiang,

Shan

et al. 2024

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method

Lian,

Sun,

Dong

et al. 2023

Open Life Sciences

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Cancer patients should be concerned about depression, which can negatively impact their mental health. To develop efficient therapies, it is essential to comprehend the connection between cancer and depression. This study used neuroimaging to investigate the use of mediator-deuterium acupuncture (MDA) for people with cancer-induced depression and its effects on brain regions associated with depression. Resting-state functional magnetic resonance imaging and neurocognitive testing were conducted on the participants, and statistical package for the social sciences was utilized to analyze the behavioral data. Clinical and theoretical data were analyzed to evaluate acupuncture’s effectiveness against gynecological cancer. In the research, there were 40 participants, 20 in each group. Except for psychomotor speed, there was no discernible difference in pre-chemotherapy cognitive test results between patients and healthy controls (HCs). However, there were substantial differences in post-treatment cognition test results, showing that the patient group had progressed. According to longitudinal graph analysis, the patient group’s local and global brain efficiency significantly declined, and lower local efficiency was associated with lower raw Trail Making Test-A results. Furthermore, poorer verbal memory scores were associated with lower overall performance in the sick group but not in the HC group. According to the research, MDA has potential as a supplemental therapy since it may improve brain function and address depression-related neurological abnormalities in cancer patients. More research is required to fully comprehend the variations between cancer and depression-related brain areas during patient therapy, maybe incorporating MDA.

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Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity

Cited by 3 publications

References 78 publications

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies

Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method

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