In order to further accelerate the realization of high-quality development of international trade and enhance the discourse power in international trade activities, this paper explores the grading and evolution of the quality of international trade development of city clusters. After analyzing the DEA static model and DEA-Malmquist dynamic evaluation model, combined with the entropy value method, the entropy value-DEA model is constructed to measure the comprehensive evaluation of the quality of international trade development of the city cluster, and the results are comprehensively analyzed. In addition, combined with the Logit-ISM model to analyze the factors affecting the development quality of international trade of city cluster and explore the grading and evolution of the development quality of international trade of city cluster from two perspectives of global statistics and global spatial trend. The results show that the fluctuation of the trade structure score is smaller than the trade scale, with an average growth rate of 0.165, and the trade competitiveness score basically stays in a state of growth except for 2008 and 2009, with an average annual growth rate of 0.972. The urban agglomerations in the eastern region account for a total of 0.38 of the city agglomerations in the city agglomerations synthesis, and the number of prefectural-level cities included is 106, which accounts for a total of 0.52 of the number of prefectural-level cities included in the city agglomerations. The quality of international trade development in city clusters in the eastern and northeastern regions stands out as the most significant. Based on the research in this paper, we advocate for the balanced development of the quality rating and evolution of each city cluster in international trade development.