In recent years, with the interaction and integration of modern cultural and creative industries with Chinese excellent traditional culture, various innovative cultural and creative products have been introduced, ushering in new opportunities for the inheritance and development of Chinese excellent traditional culture. In order to integrate Chinese cultural elements into the design of cultural and creative products. This paper draws on the characteristics of DNA inheritance and mutation in living organisms to construct a multi-objective optimization model of DNA elements, and by applying the model to the analysis stage of cultural and creative product design, the designed products can be more completely integrated into the elements of Chinese characteristic culture to effectively guide the design practice of cultural and creative products. This paper takes Dunhuang Tang Dynasty Feitian cultural elements as an example for practical research through the integration of Dunhuang Tang Dynasty Feitian cultural elements of a series of cultural and creative products for the satisfaction survey from the symbolic perception, beautiful shape, functional and practical, cultural connotations, innovation and novelty of the five dimensions of the design effect assessment, the furniture category of cultural and creative products scored the highest, the average value of 4.766, the cultural and creative products in the symbolic perception of the dimensions of the score is high. It shows that in the Dunhuang Tang Dynasty, Feitian cultural and creative products can be perceived as symbols of the characteristic culture of the period.