Afferent projections to the dorsal and ventral respiratory nuclei in the medulla oblongata of the cat studied by the horseradish peroxidase technique

Bystrzycka, E

doi:10.1016/0006-8993(80)90670-8

Cited by 83 publications

(17 citation statements)

References 13 publications

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“…Ex cepting for this difference in terminology, the labeling patterns in both experiments correlate very well with each other includ ing the appearance of HRP positive cells in the pars lateralis of the paragigantocel lular region that were described by the au thor. The more isolated 'ambiguus' nuc leus cell labeling described by Bystrzycka [1980] and also by Kalia [1981] following Sol injections is harder to match with our observations. An analysis of new data per taining to an expanded view of the cell groups making up the nucleus ambiguus in the branchial efferent cell column fol lows the present discussion.…”

Section: Recent Findingscontrasting

confidence: 56%

Observations on the Connectivity of the Parvicellular Reticular Formation with Respect to a Vomiting Center

Mehler

1983

Brain Behav Evol

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The intrinsic and extrinsic connections of the parvicellular reticular formation (PCRF) that have been demonstrated by fiber degeneration studies and studied by more recently introduced horseradish peroxidase retrograde cell labeling are reviewed in an attempt to delgit the connectivity of the region in the PCRF where electrical stimulation produced emesis. Evidence is presented that certain specific functional subdivisions in PCRF such as the salivatory nuclei and the cells which give rise to the vestibular efferent projections can be delimited.An attempt is made to differentiate the sources of brain stem afferent connections with the nucleus of the tractus solitarius, the vagal nucleus and the nucleus ambiguus complex. The literature bearing on the histochemistry of the brain stem is reviewed in a search for clues to possible unique histo- or immunochemical cytological subdivisions in the parvicellular reticular formation.

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Section: Recent Findingscontrasting

confidence: 56%

Observations on the Connectivity of the Parvicellular Reticular Formation with Respect to a Vomiting Center

Mehler

1983

Brain Behav Evol

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“…The SLN afferents terminate in the NTS (Kalia & Mesulam, 1980) and the projections from the NTS to the ipsilateral nucleus ambiguus are identified (Loewy & Burton, 1978;Bystrzycka, 1980). Also, second-order sensory neurones excited by laryngeal afferents were demonstrated in the NTS and adjacent regions (Sessle, 1973;Berger, 1977;Bellingham & Lipski, 1988).…”

Section: Discussionmentioning

confidence: 99%

Synaptic events in ventral respiratory neurones during apnoea induced by laryngeal nerve stimulation in neonatal pig.

Czyzyk-Krzeska

Lawson

1991

The Journal of Physiology

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SUMMARY1. Postsynaptic potentials evoked by electrical stimulation of superior laryngeal nerve (SLN) were recorded during SLN-induced apnoea from the respiratory neurones of the ventral respiratory group (VRG) in pentobarbitone-anaesthetized, vagotomized and artificially ventilated newborn piglets (n = 14, 4-7 days old). All recorded inspiratory (n = 10), post-inspiratory (n = 10) and expiratory (n = 20) neurones had a triphasic pattern of membrane potential and were identified for their projections to the spinal cord or cervical vagus nerve.2. During long-lasting apnoea, induced by SLN stimulation, the membrane potential trajectory of each type of recorded neurone was held at the level corresponding approximately to the membrane potential reached during stage I of expiration. Compound postsynaptic potentials evoked in most respiratory-related neurones had an early short-lasting and a late long-lasting component.3. Postsynaptic potentials in four out of seven inspiratory neurones, in which postsynaptic potentials were well demonstrated, were characterized by an early depolarization followed by long-lasting hyperpolarization. In three other inspiratory neurones only late hyperpolarization was present. The reversal of the late hyperpolarization by intracellular chloride injection was achieved to a different degree in the early and late portions of late hyperpolarization.4. Postsynaptic potentials evoked in expiratory neurones were studied in sixteen neurones and displayed two patterns: early hyperpolarization followed by longlasting hyperpolarization (n = 7, six were not antidromically activated after spinal cord stimulation) or early hyperpolarization followed by late depolarization (n = 9, eight projected to the spinal cord). The early hyperpolarization was readily reversed by chloride injection. The late hyperpolarization was more difficult to reverse and usually the reversal was not completed.5. Postsynaptic potentials evoked in post-inspiratory neurones showed a pattern of two consecutive phases of depolarization.6. The present study revealed that during long-lasting apnoea evoked by SLN stimulation each category of VRG respiratory neurones received a temporally synchronized combination of an initial fast input derived reflexly from laryngeal MS 8566 5-2

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“…The ventral group consists of inspiratory and expiratory neurones lying in a region associated with the nucleus paraambiguus and retroambigalis in the vicinity of the nucleus ambiguus and having bulbospinal or propriobulbar axons (Batsel, 1964;Merrill, 1970;Bianchi, 1971). Recently, a third group of respiratory neurones, at the rostral extension of the ventral respiratory group, has been identified by neuroanatomical (Kalia, Feldman & Cohen, 1979 ;Bystrzycka, 1980) and electrophysiological (Lipski & Merrill, 1980;Bianchi & Barillot, 1982;Fedorko & Merrill, 1984) studies. This group includes the so-called 'B6tzinger complex' which consists primarily of expiratory neurones (Lipski & Merrill, 1980) and the retrofacial group, including respiratory neurones of both the 'Botzinger complex' and the retrofacial nucleus (Bianchi & Barillot, 1982;Bianchi, 1985).…”

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confidence: 99%

Electrophysiological properties of rostral medullary respiratory neurones in the cat: an intracellular study.

Bianchi¹,

Grélot²,

Iscoe³

et al. 1988

The Journal of Physiology

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SUMMARY1. We recorded the membrane potentials of sixty-three respiratory neurones in the rostral, ventral medulla of decerebrate vagotomized cats. Stable recordings were obtained in thirty-eight expiratory and twenty-five inspiratory neurones. Axonal projections were identified by antidromic invasion after electrical stimulation of the region of the dorsal respiratory group (DRG), spinal cord, and the cervical vagus, superior laryngeal and pharyngeal nerves.2. Two types of expiratory neurones were encountered: those in which the membrane potential progressively depolarized (augmenting neurones, n = 22) and those in which the membrane potential repolarized (decrementing or post-inspiratory neurones, n = 16) during the interval between phrenic bursts. Both types were hyperpolarized during inspiration by chloride-dependent, inhibitory postsynaptic potentials (IPSPs) which decreased membrane resistance. In augmenting neurones two waves of IPSPs appeared, one early and one late in inspiration.3. Five out of seventeen augmenting expiratory neurones tested were antidromically activated by contralateral stimulation of the spinal cord (n = 3) or the DRG (n = 2). Spinal axons were not detected in any of the sixteen decrementing expiratory neurones tested. Of thirteen expiratory neurones tested with pharyngeal nerve stimulation, one (an augmenting type) was antidromically activated. Superior laryngeal or vagal axons could not be demonstrated for any expiratory neurones.4. Two types of inspiratory neurones were also encountered: those displaying progressive depolarization throughout inspiration (n = 5) and those which gradually repolarized after maximal depolarization at the onset of inspiration (n = 10). None of the former had identifiable spinal or medullary axons, but superior laryngeal axons were demonstrated in three and pharyngeal axons were found in three. None of the latter was antidromically activated from any of the sites stimulated.5. Stimulation of the superior laryngeal or pharyngeal nerves evoked excitatory postsynaptic potentials (EPSPs) in all neurones except in post-inspiratory neurones.

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Afferent projections to the dorsal and ventral respiratory nuclei in the medulla oblongata of the cat studied by the horseradish peroxidase technique

Cited by 83 publications

References 13 publications

Observations on the Connectivity of the Parvicellular Reticular Formation with Respect to a Vomiting Center

Observations on the Connectivity of the Parvicellular Reticular Formation with Respect to a Vomiting Center

Synaptic events in ventral respiratory neurones during apnoea induced by laryngeal nerve stimulation in neonatal pig.

Electrophysiological properties of rostral medullary respiratory neurones in the cat: an intracellular study.

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