Afferent regulation of glycine receptor distribution in the gerbil LSO

Koch, Ursula; Sanes, Dan H.

doi:10.1002/(sici)1097-0029(19980501)41:3<263::aid-jemt9>3.0.co;2-u

Cited by 18 publications

(10 citation statements)

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“…This gradient became clearer after P10. These findings are consistent with the quantitative autoradiographic data reported in the developing gerbil and the recent report on gephyrin distribution in the gerbil at P21 (Koch and Sanes, 1998). A number of differences in the anatomical, physiological, and immunocytochemical features between the two limbs have been reported previously (Sanes et al, , 1990Hafidi et al, 1994Hafidi et al, , 1996, leading Sanes to hypothesize that the two limbs should really be thought of as two separate nuclei.…”

Section: Differences Between the Lso Medial And Lateral Limbssupporting

confidence: 90%

Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: A light and electron microscopic study

Korada

Schwartz

1999

J. Comp. Neurol.

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Inhibitory synaptic transmission is known to play an important role during the maturation of central auditory pathways. While there is a lot of information on the modulatory role of glycine (Gly) on the postsynaptic target nuclei in the developing auditory brain stem, such a role for gamma‐aminobutyric acid (GABA) in the lateral superior olive (LSO) of neonatal gerbil has been only recently reported (Kotak and Sanes [1997] Soc Neurosci Abst 23:1549; Kotak et al. [1998] J Neurosci 18:4646–4655). Here we present further immunohistochemical findings and the first ultrastructural evidence documenting a significant decrease in the postsynaptic localization of the β2,3 subunit of the GABAA receptor from postnatal day (P)4 to P14 in the LSO of gerbil and the shift in the location of most of the staining from dendritic to astroglial over the same time course. There was a concomitant increase in staining for the Gly receptor (GlyR) anchoring protein, gephyrin. At the same time, GABA and Gly did not show a significant change in their staining pattern, suggesting that the transmitter levels are not particularly indicative of the inhibitory function in the neonatal gerbil LSO, but their receptors on the postsynaptic cells are. The observations of the present study suggest that the early GABAergic inhibition may be important in establishing appropriate synaptic contacts in the LSO of gerbil. J. Comp. Neurol. 409:664–681, 1999. © 1999 Wiley‐Liss, Inc.

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Section: Differences Between the Lso Medial And Lateral Limbssupporting

confidence: 90%

Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: A light and electron microscopic study

Korada

Schwartz

1999

J. Comp. Neurol.

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“…As shown in Figure 2B, the arbors were more spread out, similar to those in younger animals [53]. Consistent with this finding, bilateral SNHL prevented the distribution of glycine receptors from attaining the adult pattern [54]. Together, these studies suggest that the refinement of inhibitory MNTB arbors within LSO is delayed or prevented by SNHL.…”

Section: Hearing Loss Affects Sound Localization: Role Of Altered Inhsupporting

confidence: 75%

Developmental Hearing Loss Disrupts Synaptic Inhibition: Implications for Auditory Processing

2009

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Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatomical and physiological alterations of inhibitory connections at several regions within the central auditory pathway following hearing loss. Such aberrant inhibitory synaptic function may be linked to deficits in encoding binaural and spectral cues. Understanding the cellular changes that occur at inhibitory synapses following hearing loss may provide specific loci that can be targeted to improve function.

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“…Since older animals have a much lower mIPSC frequency compared to young or noise‐reared animals, and the paired pulse ratio does not differ between these three groups, it favours the hypothesis that the mature MSO principal cells are innervated by only a few glycinergic inputs, whereas young and noise‐reared animals, which both have larger peak conductances, have more synapses impinging on these cells. These findings are likely to be related to the activity‐dependent pruning of the glycinergic synapses after hearing onset, which has been demonstrated morphologically in the superior olivary complex (Sanes & Takacs, 1993; Koch & Sanes, 1998; Kapfer et al 2002). Fewer synaptic inputs would ensure precise synaptic timing and thereby improve the encoding of auditory cues during the process of ITD coding.…”

Section: Discussionmentioning

confidence: 81%

Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset

Magnusson

Kapfer

Grothe

et al. 2005

The Journal of Physiology

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122

143

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The neurones of the medial superior olive (MSO) are the most temporally sensitive neurones in the brain. They respond to the arrival time difference of sound at the two ears with a microsecond resolution; these interaural time differences are used to localize low-frequency sounds. In addition to the excitatory inputs from each ear, the MSO neurones also receive binaural glycinergic projections, which have a critical role in sound localization processing. Recently, it was shown that the glycinergic input to the MSO undergoes an experience-dependent structural reorganization after hearing onset. To explore the maturation of inhibition during the development of sound localization on a cellular level, glycinergic currents and potentials were measured in gerbil MSO principal cells from postnatal (P) day P12-P25 by whole-cell patch-clamp recordings. The synaptic glycinergic currents accelerated to rapid decay kinetics (∼2 ms) and rise times (∼0.4 ms) after hearing onset, reaching maturity around P17. Since the kinetics of miniature glycinergic currents did not change with age, it is likely that a higher degree of transmitter release synchrony is the underlying mechanism influencing the acceleration of the kinetics. During the same period, the synaptic glycinergic potentials accelerated four-fold, largely as a result of a prominent decrease in input resistance. In accordance with a reorganization of the glycinergic inputs, the evoked peak conductances decreased more than two-fold, together with a three-fold reduction in the frequency of miniature events after hearing onset. These age-dependent changes were absent in animals that had been reared in omni-directional noise, indicating that an experience-dependent pruning of synaptic inputs is important for the maturation of functional inhibition in the MSO. Taken together, these striking developmental adjustments of the glycinergic inhibition in the MSO most probably reflect an adaptation to improve the encoding of auditory cues with great temporal precision and fidelity during the maturation of sound localization behaviour.

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Afferent regulation of glycine receptor distribution in the gerbil LSO

Cited by 18 publications

References 50 publications

Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: A light and electron microscopic study

Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: A light and electron microscopic study

Developmental Hearing Loss Disrupts Synaptic Inhibition: Implications for Auditory Processing

Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset

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