Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy

Bérard, Véronique; Lesniewska, Éric; Andrés, Camilo; Pertuy, D; Laroche, C; Pourcelot, Y.

doi:10.1016/s0378-5173(02)00400-3

Cited by 48 publications

(23 citation statements)

References 25 publications

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“…When compared directly, colloidal probe AFM proved to be superior to the tensile strength technique as the distribution of results was considerably narrower. A number of similar colloidal probe experiments carried out by other groups also confirmed the dominance of capillary forces between particles over electrostatic interactions at increasing levels of humidity (Berard et al, 2002a;Tsukada et al, 2004;Young et al, 2003). These experiments were carried out at different RH and with different API and carrier materials.…”

Section: Adhesion Measurementssupporting

confidence: 53%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Section: Adhesion Measurementssupporting

confidence: 53%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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“…Tribocharging was observed for PTFE on repeated contact. Berard et al [628] studied influence of humidity on the adhesion between lactose particles and the surface of zanamivir crystals. By comparing cohesive versus adhesive forces, Beagat et al [629] concluded that a budesonide/lactose powder formulation would exhibit poor blend homogeneity, whereas for salbutamol/ lactose good blending is expected.…”

Section: Adhesion Of Drug Substancesmentioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,242

2,949

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“…Subsequently, the influence of RH on the topology and adhesion force between drug probes and lactose carriers was studied [21,41,167]. The influence of fine particles on the adhesion forces between the drug probe and lactose has also been determined [168,169].…”

Section: Direct Interparticulate Adhesion Force Determinationmentioning

confidence: 99%

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

179

113

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Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy

Cited by 48 publications

References 25 publications

Characterisation of dry powder inhaler formulations using atomic force microscopy

Characterisation of dry powder inhaler formulations using atomic force microscopy

Force measurements with the atomic force microscope: Technique, interpretation and applications

Lactose characteristics and the generation of the aerosol

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