2009
DOI: 10.1080/02652030802308472
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Aflatoxin–albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population

Abstract: A study of aflatoxin (AF) exposure and the levels of vitamins A and E was carried out with a group of 507 Ghanaian participants. AFB(1)-albumin adducts (AFB-AA) were measured by radioimmunoassay and vitamins A and E were measured by high-performance liquid chromatography (HPLC). The average level of serum AFB-AA was 0.94 +/- 0.64 (range = 0.1-4.44) pmol mg(-1) albumin. Mean levels of vitamins A and E were 1.32 +/- 0.48 (range = 0.41-4.85) micromol l(-1) and 15.68 +/- 4.12 (range = 6.35-30.40) micromol l(-1), r… Show more

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Cited by 34 publications
(21 citation statements)
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“…It is worth noting that the dose range selected in the repeated experiment (5-75 μg/kg BW) was relevant to the exposure levels in high-risk human populations, such as Kenya, Ghana, and Guangxi, China, where the mean AFB 1 levels were found to be 100-1000 μg/kg in corn (Azziz-Baumgartner et al, 2005; Groopman et al, 1992; Tang et al, 2009). We observed a linear increase of serum AFB-Lys for animals that received 5-25 μg AFB 1 /kg daily, leading to a 1.0-1.5 times increase after 5 weeks compared to that after 1 week, which supports its potential use as a long-term biomarker.…”
Section: Discussionmentioning
confidence: 99%
“…It is worth noting that the dose range selected in the repeated experiment (5-75 μg/kg BW) was relevant to the exposure levels in high-risk human populations, such as Kenya, Ghana, and Guangxi, China, where the mean AFB 1 levels were found to be 100-1000 μg/kg in corn (Azziz-Baumgartner et al, 2005; Groopman et al, 1992; Tang et al, 2009). We observed a linear increase of serum AFB-Lys for animals that received 5-25 μg AFB 1 /kg daily, leading to a 1.0-1.5 times increase after 5 weeks compared to that after 1 week, which supports its potential use as a long-term biomarker.…”
Section: Discussionmentioning
confidence: 99%
“…Chronic exposure to low levels of AFB 1 is a risk factor in the aetiology of human hepatocellular carcinoma (HCC) in several regions of Africa and Southeast Asia, particularly in conjunction with hepatitis B virus infection (IARC 1993(IARC , 2002Wild & Hall 2000;Wogan et al 2012). Importantly, AFB 1 has also been shown to be an anti-nutritional agent that reduces concentrations of vitamins and proteins in animals and humans (Gong et al 2002;Williams et al 2004;Wild 2007;Tang et al 2009). Further, it is a potent immunotoxic agent in animals and also changes T-cell phenotypes in humans, which may aggravate the burden of infectious diseases in the developing world (Williams et al 2004;Jiang et al 2005;Wild 2007).…”
Section: Please Scroll Down For Arti Clementioning
confidence: 99%
“…25 In another study involving 507 Ghanaian participants, AFB 1 -lysine adduct levels were statistically higher in subjects who had low levels of both vitamins A and E compared to subjects who had high vitamins A and E. 26 A cohort study involving 472 Gambian children of ages 6-9 years were recruited for analysis of possible correlation of aflatoxin exposure and immune status. Immune parameters included secretory IgA (sIgA) in saliva and cell-mediated immunity (CMI).…”
Section: Discussionmentioning
confidence: 99%