Aflatoxin B1 and viruses’ combined pathogenesis: A mini systematics review of invitro and invivo studies

Ahmadi, Mehdi; Shahbahrami, Ramin; Khajeh, Fatemeh; Khodaeivandi, Sepideh; Kakavandi, Ehsan; Raziabad, Reza Hazrati; Ghanati, Kiandokht

doi:10.1016/j.acthis.2023.152116

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…The AFB1 was able to increase the efficiency of EBV infection in primary B cells via an increase in DNA replication [82]. Other studies have determined that AFB1 is able to enhance both EBV and influenza virus severity and acts as a co-factor for EBV HBV carcinogenicity [83]. In other genome-wide association studies (GWAS), the importance of hereditary conditions contributing to the viral and environmental risk factors was presented.…”

Section: Hepatocarcinoma With Respect To Afb1 Toxicitymentioning

confidence: 99%

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

Pożarska,

Karpiesiuk,

Kozera

et al. 2024

IJMS

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Aims: The current review aims to outline and summarize the latest research on aflatoxin, with research studies describing natural, herbal and chemical compound applications in animal (pig) models and in vitro cellular studies. Aflatoxin, a carcinogenic toxin metabolite, is produced by Aspergillus flavus in humid environments, posing a threat to human health and crop production. The current treatment involves the prevention of exposure to aflatoxin and counteracting its harmful toxic effects, enabling survival and research studies on an antidote for aflatoxin. Objectives: To summarize current research prospects and to outline the influence of aflatoxin on animal forage in farm production, food and crop processing. The research application of remedies to treat aflatoxin is undergoing development to pinpoint biochemical pathways responsible for aflatoxin effects transmission and actions of treatment. Significance: To underline the environmental stress of aflatoxin on meat and dairy products; to describe clinical syndromes associated with aflatoxicosis on human health that are counteracted with proposed treatment and preventive interventions. To understand how to improve the health of farm animals with feed conditions.

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Section: Hepatocarcinoma With Respect To Afb1 Toxicitymentioning

confidence: 99%

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

Pożarska,

Karpiesiuk,

Kozera

et al. 2024

IJMS

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The Potential Influence of the Presence of Mycotoxins in Human Follicular Fluid on Reproductive Outcomes

Szentirmay,

Molnár,

Plank

et al. 2024

Toxins

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The effect of mycotoxin exposure on follicular fluid composition and reproductive outcomes in women undergoing in vitro fertilisation (IVF) was investigated in this study. Twenty-five patients were included, and follicular fluid and serum samples were analysed for various mycotoxins. Principal observations:1. Mycotoxin presence: All examined mycotoxins were detected in follicular fluid. Follicular fluid (ff) levels: Deoxynivalenol (DON), alfa-Zearalenol (α-ZOL), Zearalenone (ZEN), and total aflatoxin (AFs) were significantly higher in follicular fluid than in serum. 2. Follicular fluid and reproductive outcomes: A positive correlation was observed between the ratio of oocytes to total follicles and the follicular Fumonisin B1 (FB1) levels. Multiple linear regression analysis revealed a significant relationship between DON and T-2/HT-2 toxins (T2/HT2) levels in the follicular fluid. 3. Hormone levels: Follicular 17-beta estradiol (E2) and progesterone (P4) levels were higher than the serum levels. Follicular P4 correlated with serum P4 and Anti-Müllerian hormone (AMH) levels. In contrast, follicular E2 did not correlate with plasma E2 levels. 4. Mycotoxin–hormone interactions: A positive correlation was observed between follicular P4 and T2/HT2 toxin levels, whereas a negative correlation was found between ffE2 and ffT2/HT2, and a positive correlation was found between ZEN and E2. Conclusion: This study elucidated the presence of various mycotoxins in the follicular fluid and their potential influence on reproductive outcomes. Further research is warranted to clarify the specific mechanisms underlying these effects and develop strategies for detecting mycotoxin exposure in women undergoing IVF.

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Aflatoxin B1 and viruses’ combined pathogenesis: A mini systematics review of invitro and invivo studies

Cited by 2 publications

References 39 publications

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

The Potential Influence of the Presence of Mycotoxins in Human Follicular Fluid on Reproductive Outcomes

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