Aflatoxins

Smith, Joshua W.; Groopman, John D.

doi:10.1016/b978-0-12-801238-3.65030-4

Cited by 5 publications

(3 citation statements)

References 208 publications

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“…Only the 8,9-exo-epoxy-AFB1 isomer exhibits mutagenic activity by forming adducts with DNA or proteins, while the endo isomer is non-toxic. Due to interindividual variability in the expression of cytochrome P450 enzymes, some individuals may be more susceptible to the formation of the toxic metabolite, thus having an increased risk of developing liver carcinoma [34].…”

Section: Food Contamination With Afb1 (Incidence Toxicity and Legal L...mentioning

confidence: 99%

Recent Progress of Electrochemical Aptasensors toward AFB1 Detection (2018–2023)

Ciobanu,

Hosu-Stancioiu,

Melinte

et al. 2023

Biosensors

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Food contaminants represent possible threats to humans and animals as severe food safety hazards. Prolonged exposure to contaminated food often leads to chronic diseases such as cancer, kidney or liver failure, immunosuppression, or genotoxicity. Aflatoxins are naturally produced by strains of the fungi species Aspergillus, which is one of the most critical and poisonous food contaminants worldwide. Given the high percentage of contaminated food products, traditional detection methods often prove inadequate. Thus, it becomes imperative to develop fast, accurate, and easy-to-use analytical methods to enable safe food products and good practices policies. Focusing on the recent progress (2018–2023) of electrochemical aptasensors for aflatoxin B1 (AFB1) detection in food and beverage samples, without pretending to be exhaustive, we present an overview of the most important label-free and labeled sensing strategies. Simultaneous and competitive aptamer-based strategies are also discussed. The aptasensors are summarized in tabular format according to the detection mode. Sample treatments performed prior analysis are discussed. Emphasis was placed on the nanomaterials used in the aptasensors’ design for aptamer-tailored immobilization and/or signal amplification. The advantages and limitations of AFB1 electrochemical aptasensors for field detection are presented.

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Section: Food Contamination With Afb1 (Incidence Toxicity and Legal L...mentioning

confidence: 99%

Recent Progress of Electrochemical Aptasensors toward AFB1 Detection (2018–2023)

Ciobanu,

Hosu-Stancioiu,

Melinte

et al. 2023

Biosensors

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“…Aflatoxins are highly toxic and heat‐tolerant secondary metabolites that are difficult to convert to nontoxic substances. Aflatoxins are a series of known sulfur polycyclic compounds that emit fluorescence light when exposed to ultraviolet light (Smith & Groopman, 2018). Among them, aflatoxin B1 (AFB1) is a potent mycotoxin, extremely toxic, mutagenic, and carcinogenic, causing chromosomal defects and hepatoxicity in humans.…”

Section: Introductionmentioning

confidence: 99%

The synergistic effect of titanium dioxide nanoparticles and yeast isolated from fermented foods in reduction of aflatoxin B1

Nasiri Poroj,

Larypoor,

Fazeli

et al. 2023

Food Science & Nutrition

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The presence of aflatoxins in food products can lead to health risks in human societies. Therefore, in the present study, the effect of yeast strains isolated from fermented products and titanium dioxide nanoparticles (TiO2‐NPs) was studied on aflatoxin reduction. Yeast strains were isolated from fermented products such as sweet fruits and dairy products and identified using biochemical, ascospore (testing by culture medium optimization V8 which is called V8NLF), and molecular methods. The probiotic activity of four selected yeasts was evaluated. Then, the effect of selected yeast isolates and TiO2‐NPs on reducing aflatoxin B1 (AFB1) in the medium was studied by measuring AFB1 using ELISA and HPLC. The results of biochemical and molecular identification experiments indicate that the selected strain (Y1) is Saccharomyces cerevisiae. The selected strains showed good tolerance to different concentrations of bile salt, pH, and NaCl, indicating appropriate probiotic activity. It also showed antimicrobial activity against Escherichia coli, Shigella dysenteriae, and Salmonella typhimurium. Selected strain and TiO2‐NPs showed AFB1 reducing activity in the medium and when combined, showed synergistic effects in reducing AFB1. TiO2‐NPs in combination with selected yeast strains have a high ability to remove AFB1 from the medium and, therefore, can be used for future studies.

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“…Aflatoxin B1 (AFB1)is the most frequent and the most toxic member of this group, while aflatoxin M1 (AFM1) is a metabolite of AFB1 which is a common contaminant in milk (Fig. 1) (Bennett and Klich 2003;Klingelhöfer et al 2018;Smith and Groopman 2019). Sterigmatocystin (STC; Fig.…”

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confidence: 99%

Testing the extraction of 12 mycotoxins from aqueous solutions by insoluble beta-cyclodextrin bead polymer

Mohos

Faisal

Fliszár-Nyúl

et al. 2021

Environ Sci Pollut Res

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Mycotoxins are toxic metabolites of filamentous fungi; they are common contaminants in numerous foods and beverages. Cyclodextrins are ring-shaped oligosaccharides, which can form host-guest type complexes with certain mycotoxins. Insoluble beta-cyclodextrin bead polymer (BBP) extracted successfully some mycotoxins (e.g., alternariol and zearalenone) from aqueous solutions, including beverages. Therefore, in this study, we aimed to examine the ability of BBP to remove other 12 mycotoxins (including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol) from different buffers (pH 3.0, 5.0, and 7.0). Our results showed that BBP can effectively extract citrinin, dihydrocitrinone, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol at each pH tested. However, for the removal of ochratoxin A, BBP was far the most effective at pH 3.0. Based on these observations, BBP may be a suitable mycotoxin binder to extract certain mycotoxins from aqueous solutions for decontamination and/or for analytical purposes.

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Aflatoxins

Cited by 5 publications

References 208 publications

Recent Progress of Electrochemical Aptasensors toward AFB1 Detection (2018–2023)

Recent Progress of Electrochemical Aptasensors toward AFB1 Detection (2018–2023)

The synergistic effect of titanium dioxide nanoparticles and yeast isolated from fermented foods in reduction of aflatoxin B1

Testing the extraction of 12 mycotoxins from aqueous solutions by insoluble beta-cyclodextrin bead polymer

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