Aflatoxins and Fumonisins in Corn from the High-Incidence Area for Human Hepatocellular Carcinoma in Guangxi, China

Li, Fengqin; Yoshizawa, Takumi; Kawamura, Osamu; Luo, Xueyun; Li, Yuwei

doi:10.1021/jf010143k

Cited by 155 publications

(97 citation statements)

References 17 publications

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“…In China, an earlier study suggested the location of high-risk regions along the southeastern coastline, that is in the provinces of Jiangsu, Zhejiang, Fujan, Guangdong and Guangxi Autonomous Region (Yeh et al, 1989). HBV and the dietary aflatoxins have been suggested as the most important HCC hazard factors in China (Li et al, 2001), where HBV infection is almost a prerequisite for the onset of HCC in the high-risk regions (Yeh et al, 1989;Shen et al, 1991). Dietary exposure to aflatoxin B1 (AFB1) (Li et al, 2001;Wang et al, 2001;Wang and Liu, 2007) may associate with HCC risk in Chinese cohorts due to enhancement of the mutation frequency of the third nucleotide of codon 249 of TP53 (Deng et al, 1997;Kirk et al, 2000;Szymanska et al, 2009) and oxidative stress (Wu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…HBV and the dietary aflatoxins have been suggested as the most important HCC hazard factors in China (Li et al, 2001), where HBV infection is almost a prerequisite for the onset of HCC in the high-risk regions (Yeh et al, 1989;Shen et al, 1991). Dietary exposure to aflatoxin B1 (AFB1) (Li et al, 2001;Wang et al, 2001;Wang and Liu, 2007) may associate with HCC risk in Chinese cohorts due to enhancement of the mutation frequency of the third nucleotide of codon 249 of TP53 (Deng et al, 1997;Kirk et al, 2000;Szymanska et al, 2009) and oxidative stress (Wu et al, 2008). However, among R e t r a c t e d individuals at very high risk of liver cancer due to infection with HBV and AFB1 exposure, only 20% eventually develop liver cancers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

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Primary hepatocellular carcinoma (HCC) is highly prevalent in China. Although hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are considered the major risk factors, among the high-risk cohorts only a small fraction develops liver cancer. Therefore, we investigated if organochlorine pesticides (OCPs) exposure contributed to HCC risk in the Xiamen population. The questionnaire database was built from 346 HCC cases and 961 healthy controls during [2007][2008][2009]. The serum levels of a-, b-, g-, d-HCH, p, p 0 -DDT, p, p 0 -DDE, o, p 0 -DDT and p, p 0 -DDD were measured by gas chromatography-tandem mass spectrometer and statistical analysis was done using SPSS16. Significantly, we observed p, p 0 -DDT, p, p 0 -DDE, and at first time b-HCH displayed quartile dose-dependent HCC risk trends; p, p 0 -DDT showed positive (i.e., synergistic) interactions with HBV, diabetes mellitus, AFB1 and polycyclic aromatic hydrocarbon (PAH) exposure, but negative (i.e., antagonistic) interaction with heavy drinking; p, p 0 -DDE had positive interaction with PAH but negative interaction with HBV and p, p 0 -DDT; and b-HCH was positively interacted with p, p 0 -DDT but negatively interacted with heavy drinking and diabetes. p, p 0 -DDT, p, p 0 -DDE and b-HCH were independent HCC risk factors. Because of their synergistic interactions with other factors, the high level exposure combined with common AFB1 and HBV exposure in the investigated area may greatly enhance the risk of HCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

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“…Diabetes increased the risk of liver cancers in patients with hepatitis and/or cirrhosis and it was concluded and confirmed by a few subsequent reported studies, although the modified factors were different in different studies. 51,62,63 Ei-Serag et al 54 also demonstrated that DM was also shown to increase the risk of primary liver cancers only in the presence of other risk factors such as hepatitis C or B, or alcoholic cirrhosis. In a cohort study, Lai et al 63 found that the association between type 2 DM and incidence of HCC was modified by HCV status after controlling for age, sex, HBV, HCV, smoking, and alcohol consumption.…”

Section: Impact Of Diabetes As Risk Factor In Hepatocellular Carcinomamentioning

confidence: 99%

“…The association between DM and HCC was found to be modified by hepatitis virus infection, heavy alcohol consumption, and other known risk factors. 51,[61][62][63] Fujino et al 2001 61 found that the relative risk (RR) of DM for primary liver cancers was 2.06 (95% CI, 1.01-4.19) after adjustment for smoking, alcohol, and diseases associated with liver cancer in a prospective study of diabetes and liver cancers in Japan. Diabetes increased the risk of liver cancers in patients with hepatitis and/or cirrhosis and it was concluded and confirmed by a few subsequent reported studies, although the modified factors were different in different studies.…”

Section: Impact Of Diabetes As Risk Factor In Hepatocellular Carcinomamentioning

confidence: 99%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma (HCC) is an important cause of death all over the world, more so in Asia and Africa. The representative data on epidemiology of HCC in India is very scanty and cancer is not a reportable disease in India and the cancer registries in India are mostly urban. 45 million people who are suffering from chronic Hepatitis B virus (HBV) infection and approximately 15 million people who are afflicted with chronic Hepatitis C virus (HCV) infection in India. HBV and HCV infection is considered an important etiologic factor in HCC. Positive association between HCC and consumption of alcohol where alcohol contribute as a cofactor for hepatotoxins and hepatitis viruses. Aflatoxin contamination in the diets, Hepatitis B virus infection and liver cirrhosis in Andhra Pradesh, India and direct chronic exposure to aflatoxins was shown to cause liver cirrhosis. Cirrhosis of liver of any cause lead to develop about 70%-90% of HCC. Aflatoxin interact synergistically with Hepatitis B virus (HBV)/Hepatitis C virus (HCV) infection which increase the risk of HCC. HBV infection, HBV infection with Aflatoxin exposure, viral infection and alcohol consumption leading to overt cirrhosis of the liver, alcohol consumption leading to cirrhosis of the liver with viral infection are the predominant risk factor for the development of HCC. HCV and alcohol are also associated with HCC in India. Indians develop diabetes at younger age, Asians have strong genetic susceptibility for type II diabetes. Diabetes mellitus is identified as a risk factor for HCC. Prevention of viral infection by universal vaccination against hepatitis virus, HCC surveillance program, preventing alcoholic liver diseases, fungal contamination of grains and ground crops to prevent basically Aflatoxin exposure are important measures to prevent liver diseases and HCC among those at risk. ( J CLIN EXP HEPATOL 2014;4:S34-S42)

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“…HBV and the dietary aflatoxins have been suggested as the most important HCC hazard factors in China (Li et al, 2001), where HBV infection is almost a prerequisite for the onset of HCC in the high-risk regions (Yeh et al, 1989;Shen et al, 1991). Dietary exposure to aflatoxin B1 (AFB1) (Li et al, 2001;Wang et al, 2001;Wang and Liu, 2007) may associate with HCC risk in Chinese cohorts due to enhancement of the mutation frequency of the third nucleotide of codon 249 of TP53 (Deng et al, 1997;Kirk et al, 2000;Szymanska et al, 2009) and oxidative stress (Wu et al, 2008). However, among individuals at very high risk of liver cancer due to infection with HBV and AFB1 exposure, only 20% eventually develop liver cancers.…”

Section: Introductionmentioning

confidence: 99%

Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case–control study

Zhao

Shen

Liu

et al. 2011

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Primary hepatocellular carcinoma (HCC) is highly prevalent in China. Although hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are considered the major risk factors, among the high-risk cohorts only a small fraction develops liver cancer. Therefore, we investigated whether organochlorine pesticide exposure contributed to HCC risk in the Xiamen population. The questionnaire database was built from 346 HCC cases and 961 healthy controls during [2007][2008][2009]. The serum levels of a-, b-, g-, d-HCH, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (p,p 0 -DDT), (1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p 0 -DDE), 1,1,1-trichloro-2,2-bis (o-chlorophenyl) ethane and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane were measured by gas chromatography-tandem mass spectrometer, and statistical analysis was done using SPSS16. Significantly, we observed p,p 0 -DDT and p,p 0 -DDE, and at the first time b-HCH displayed quartile dose-dependent HCC risk trends; p,p 0 -DDT showed positive (i.e., synergistic) interactions with HBV, diabetes mellitus, AFB1 and polyaromatic hydrocarbon (PAH) exposure, but negative (i.e., antagonistic) interaction with heavy drinking; p,p 0 -DDE had positive interaction with PAH but negative interaction with HBV and p,p 0 -DDT; and b-HCH positively interacted with p,p 0 -DDT but negatively interacted with heavy drinking and diabetes. p,p 0 -DDT, p,p 0 -DDE and b-HCH were independent HCC risk factors. Because of their synergistic interactions with other factors, the high-level exposure combined with common AFB1 and HBV exposure in the investigated area may greatly enhance the risk of HCC.

show abstract

Aflatoxins and Fumonisins in Corn from the High-Incidence Area for Human Hepatocellular Carcinoma in Guangxi, China

Cited by 155 publications

References 17 publications

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case–control study

Risk Factors for Hepatocellular Carcinoma in India

Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma: A case–control study

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