AFM analysis of anisotropic dissolution in dense hydroxyapatite

Seo, Dong Seok; Lee, Jong Kook

doi:10.1016/j.ultramic.2008.04.091

Cited by 8 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surface characteristics of nHA could be changed with this dissolution and a layer of carbonated-apatite could precipitate on the surface through seeded growth on nHA crystals. 34,35 Furthermore, it is interesting to find out the influence of other matrix phases, for example, PU on the HA tissue-bonding capacity, where urethane functional group could form a stronger bond to the collagen matrix of dentin. However, the guiding effect and the osteoconductivity of nHA is still a dominating effect in HA-containing composites.…”

Section: Discussionmentioning

confidence: 99%

Structural and in vitro adhesion analysis of a novel covalently coupled bioactive composite

et al. 2011

View full text Add to dashboard Cite

The interfacial adhesion between a restorative composite and tooth is one of the major factors that determine the ultimate performance of composite restoration. A novel polyurethane (PU) composite material was prepared by chemically binding the nano-hydroxyapatite (nHA) to the diisocyanate component in the PU backbone by utilizing solvent polymerization. The procedure involved stepwise addition of monomeric units of the PU and optimizing the reagent concentrations. The resultant materials were characterized structurally (Raman Spectroscopy) and in vitro bioactive analysis was conducted in modified-simulated body fluid for periodical time intervals. The in vitro study evaluated the push-out bond strength of existing obturating material and novel covalently linked PU/nHA composites to dentin after long-term storage in deionized water and artificial saliva. Human extracted molar roots were filled with experimental samples and analyzed at predetermined time intervals. The shear bond strength of samples was measured and surface morphologies were evaluated. Covalent bond formation was achieved between PU and nHA without intermediate coupling agent. With the increase in concentration of nHA, the composite showed more bioactivity and adhesion toward tooth structure. Bond strength of this new composite were in accordance with obutrating material, therefore, the material can be used as an obturating material because of its direct adhesion with tooth structure.

show abstract

Section: Discussionmentioning

confidence: 99%

Structural and in vitro adhesion analysis of a novel covalently coupled bioactive composite

et al. 2011

View full text Add to dashboard Cite

show abstract

“…[15][16][17] In addition, a certain crystal plane in HA showed the resistance to dissolution, and therefore, a consideration of crystallographic influence is required to understand the mechanism of HA degradation. 18 In this study, the mechanism of biological disintegration of dense hydroxyapatite at an osseous site in a dog was investigated.…”

Section: Introductionmentioning

confidence: 99%

Surface Corrosion of Nanoscaled Hydroxyapatite During an In Vivo Experiment

Seo¹,

Lee²,

Hwang³

2015

j nanosci nanotechnol

Self Cite

View full text Add to dashboard Cite

Hydroxyapatite (HA) is widely used as a bioactive ceramics as it forms a chemical bond with bone. However, the drawback to using this material is its inferior mechanical properties. In this research, surface corrosion and disintegration of nanoscaled HA in a dog were studied, and the mechanism by which phase-pure HA dissolved in vivo was investigated. Biological properties of HA in vivo are affected by the grain-boundary dissolution followed by a surface corrosion and microstructural disintegration. This kind of dissolution process, apparently evidenced at the grain boundary, causes particle generation, which indicates that both long-term bone in-growth and mechanical properties can dramatically deteriorate. Implant dissolution by osteoclasts in vivo is also observed on the surface of hydroxyapatite. Implant surface showed an aggressive corrosion by an osteoclast resorption. Severe and deeper dissolution underwent close to osteoclast resulting in formation of smaller and more round particle shape.

show abstract

“…To produce straightforward components, axial powder compaction produces little material waste, and production can be carried out at a high rate [13]. Densification processes can be carried out by pressureless sintering, hot isostatic pressing, and microwave sintering [14,15].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Cell Growth Assessment in Near Dense Hydroxyapatite Scaffold

Wiria

Tay

Ghassemieh

2013

Journal of Materials

View full text Add to dashboard Cite

This paper reports the preliminary results on the morphology of low porosity hydroxyapatite scaffold and its compatibility as a substrate for osteoblast cells. Although having low porosity, the hydroxyapatite scaffold was found to be capable of sustaining cell growth and thus assisting bone ingrowth. Due to the low porosity nature, the scaffold provides higher strength and therefore more suitable for applications with load-bearing requirements such as spinal spacer. The hydroxyapatite scaffolds are prepared via powder processing techniques, using a combination of wet mixing, powder compaction, and sintering processes. The scaffold porosity is estimated via image analysis and micro-CT, which detect porosity level of approximately 16% and pore size of 13 μm. Cell culture investigation demonstrates that the hydroxyapatite substrate is able to provide favourable cell attachment and collagen matrix production, as compared to the commonly used cell culture control substrates. These results indicate that despite the low porosity in the hydroxyapatite scaffolds, they do not hinder being a preferred substrate to provide conducive environment osteoblast cell growth.

show abstract

AFM analysis of anisotropic dissolution in dense hydroxyapatite

Cited by 8 publications

References 29 publications

Structural and in vitro adhesion analysis of a novel covalently coupled bioactive composite

Structural and in vitro adhesion analysis of a novel covalently coupled bioactive composite

Surface Corrosion of Nanoscaled Hydroxyapatite During an In Vivo Experiment

Morphological and Cell Growth Assessment in Near Dense Hydroxyapatite Scaffold

Contact Info

Product

Resources

About