Afoxolaner and fluralaner treatment do not impact on cutaneous <i>Demodex</i> populations of healthy dogs

Zewe, Christine; Altet, Laura; Lam, Andrea; Ferrer, L.

doi:10.1111/vde.12453

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…However, results of the present and previous [1] studies show that either administration approach (topical or oral) provides drug levels sufficient to achieve mite elimination. At the same time, it is interesting that an investigation into mite levels on healthy dogs treated with fluralaner did not find a significant effect on mite populations at the end of the study period [7]. One possible explanation could be that there is a difference in drug levels achieved in hair follicles in dogs with generalised demodicosis compared to the hair follicles of the unaffected dog.…”

Section: Discussionmentioning

confidence: 99%

“…One possible explanation could be that there is a difference in drug levels achieved in hair follicles in dogs with generalised demodicosis compared to the hair follicles of the unaffected dog. However, the above must be considered with caution, as the referenced study [7] evaluated the presence of mite DNA in clinically healthy animals, and not from skin scrapings of visually affected areas.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis

Fourie

Meyer²,

Thomas

2019

Parasites Vectors

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BackgroundCanine demodicosis is classified as localised or generalised according to the extent of the disease. Chronic generalised demodicosis is a difficult skin disease to treat and unlikely to resolve without therapy. This laboratory study compared the efficacy of two topical spot-on medications, fluralaner or a combination of imidacloprid and moxidectin, against naturally acquired generalised demodicosis in dogs.MethodsSixteen client-owned dogs with naturally acquired generalised demodicosis were randomly allocated to 1 of 2 study groups consisting of 8 dogs each. On Day 0, dogs in 1 group were treated once with fluralaner spot-on solution. Dogs in the other group were treated with the imidacloprid/moxidectin spot-on solution on 3 occasions (Days 0, 28 and 56) or weekly in severe cases. Mites were counted in skin scrapings and demodectic lesions were evaluated on each dog before treatment, and at 28-day intervals over the 12-week period. Deep skin scrapings were made from the same 5 sites on each dog at each examination.ResultsAfter administration of fluralaner, miticidal efficacy was 99.7% at Day 28, > 99.9% at Day 56 and 100% at Day 84. Efficacy in dogs treated topically with the imidacloprid and moxidectin combination, was 9.8% at Day 28, 45.4% at Day 56 and 0% at Day 84, and was significantly (P < 0.01) lower than the fluralaner treated group at each post-treatment time point.ConclusionsA single topical administration of fluralaner eliminated Demodex sp. mites on dogs with generalised demodicosis. Topical imidacloprid/moxidectin combination treatment administered 3 times at 28-day intervals, or more frequently, did not eliminate mites from most treated dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis

Fourie

Meyer²,

Thomas

2019

Parasites Vectors

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“…populations of normal dogs over a 90 day period and thus does not eliminate the mite population on a dog. However, this study was based on a DNA detection using simple PCR with no quantification methods or evaluation of the viability of the mites [ 28 ]. Those results should therefore be considered as not conclusive and additional studies are necessary to better understand the effect of isoxazoline on Demodex mite populations.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe

Lebon

Beccati²,

Bourdeau

et al. 2018

Parasites Vectors

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BackgroundA multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland.MethodsClient-owned dogs, diagnosed positive for Demodex mites by pre-treatment skin scrapings and presenting clinical signs of generalised demodicosis were included. Dogs were orally treated with afoxolaner three times at monthly intervals. Of the 50 dogs enrolled, 48 completed the whole study. Efficacy of the treatments was assessed monthly by Demodex mite counts and physical examination with special regard to the severity and extension of skin lesions.ResultsTreatments were well tolerated in all dogs and resulted in a rapid reduction of mites, with all post-treatment mite counts significantly lower than baseline. The number of mites was reduced by 87.6%, 96.5% and 98.1% on Days 28, 56 and 84, respectively. In addition, the skin lesion severity and extent scores as well as the pruritus were all significantly lower at all post-treatment visits compared to the pre-treatment assessment.ConclusionsThis clinical field study demonstrated that monthly administrations of afoxolaner in NexGard® or NexGard Spectra®, offered a convenient and reliable solution for the treatment of canine generalised demodicosis.

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“…The most significant decreases in mites and lesions occurred during the first 7 days [ 88 ]. In a study of healthy dogs with populations of Demodex mites, cutaneous populations of Demodex over the 90-day period were not affected by a treatment of fluralaner or afoxolaner [ 89 ]. It was suggested that isoxazoline treatments may not completely eliminate Demodex mites, but only return them to a more natural population level.…”

Section: Chemical Treatmentsmentioning

confidence: 99%

Recent Advancements in the Control of Cat Fleas

Rust¹

2020

Insects

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With the advent of imidacloprid and fipronil spot-on treatments and the oral ingestion of lufenuron, the strategies and methods to control cat fleas dramatically changed during the last 25 years. New innovations and new chemistries have highlighted this progress. Control strategies are no longer based on the tripartite approach of treating the pet, the indoor environment, and outdoors. The ability of modern therapies to break the cat flea life cycle and prevent reproduction has allowed for the stand-alone treatments that are applied or given to the pet. In doing so, we have not only controlled the cat flea, but we have prevented or reduced the impact of many of the diseases associated with ectoparasites and endoparasites of cats and dogs. This review provides an update of newer and non-conventional approaches to control cat fleas.

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Afoxolaner and fluralaner treatment do not impact on cutaneous Demodex populations of healthy dogs

Abstract: Treatment with afoxolaner or fluralaner does not impact on cutaneous Demodex populations of normal dogs over a 90 day period.

Cited by 9 publications

References 31 publications

Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis

Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis

Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe

Recent Advancements in the Control of Cat Fleas

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