More than 500 million people will be added to Africa’s cities by 2040, marking the largest urbanization in history. However, nonrenewable fossil energy sources are inadequate to meet Africa’s energy needs, and their overexploitation leads to intensified global warming. Fortunately, Africa has a huge potential for biomass energy, which will be an important option for combating climate change and energy shortage. In this study, we present a typical large-scale biogas plant in Burkina Faso, West Africa (Ouagadougou Biogas Plant, OUA), which is the first large-scale biogas generation plant in West Africa. The primary objective of OUA is to treat human feces, and it serves as a demonstration plant for generating electricity for feed-in tariffs. The objectives of this study are to assess the greenhouse gas reduction capacity and economic, environmental, and social benefits of OUA and to analyze the opportunities and challenges of developing biogas projects in Africa. As a result, the net economic profit of the OUA biogas plant is approximately USD 305,000 per year, with an anticipated static payback period of 14.5 years. The OUA plant has the capacity to treat 140,000 tons of human feces and 3000 tons of seasonal mixed organic waste annually, effectively reducing greenhouse gas emissions by 5232.61 tCO2eq, improving the habitat, and providing over 30 local jobs. Finally, the development of biogas projects in Africa includes advantages such as suitable natural conditions, the need for social development, and domestic and international support, as well as challenges in terms of national policies, insufficient funding, technical maintenance, and social culture.