African American Race Is a Correlate of Heart Failure in Breast Cancer Survivors: A Study of 26,347 Women Identified With Breast Cancer From 1973-2007

Valina-Toth, Anna Liza; Zavodnik, Theresa; Seicean, Sinziana; Plana, Juan Carlos; Marwick, Thomas

doi:10.1016/s0735-1097(13)60580-x

Cited by 2 publications

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“…Not increasing physical activity in black survivors after a diagnosis may lead to declines in cardiovascular fitness. While our data are only preliminary, an analysis of more than 26,000 women in the U.S. women found that black survivors had a 1.4-fold greater risk of heart failure than white survivors [42]. Thus, trends with regard to physical activity in this group have potential to reduce disparities in black women diagnosed with breast cancer [43].…”

Section: Discussionmentioning

confidence: 99%

The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study

Sheppard

Hicks

Makambi

et al. 2016

Contemporary Clinical Trials

104

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Purpose Black breast cancer survivors have high rates of obesity and low physical activity levels. Little is known about the acceptability and feasibility of interventions in this population. Objective A two-arm RCT was launched to assess the efficacy of a culturally targeted 12-week multimodal lifestyle intervention in overweight and obese black survivors. Methods Intervention components included nutrition education, exercise groups, and survivor-led motivational interviewing phone sessions. The analytic sample included women who completed the trial (intervention n = 10; control n = 12). Anthropometric measures, physical activity, and VO2max were assessed at baseline and follow-up. Change scores (intervention vs. control) were assessed with Wilcoxon rank-sum tests. A process evaluation assessed intervention acceptability. Results Overall adherence was 70% and overall satisfaction was high (86%). Despite the 5% weight loss target, the intervention group lost 0.8% but BMI improved. Total physical activity levels increased in the intervention vs. control arm (+3501 MET min/week vs. +965 MET min/week, respectively). VO2max improved in the intervention group (+0.10 ± 1.03 kg/L/min). Intervention participants reduced energy intake (−207.3 ± 31.5 kcals) and showed improvements in fat intake (−15.5 ± 3.8 g), fiber (+3.2 ± 1.2 g) and % energy from fat (−4.8 ± 3.1%). Survivors suggested providing diet/exercise information within a cancer context. Conclusions Group and individualized intervention strategies are acceptable to black survivors. Observed differences between self-report and objective outcomes may suggest reporting bias or changes in body composition. Increasing supervised intervention components and assessment of body composition will be important for future trials.

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Section: Discussionmentioning

confidence: 99%

The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study

Sheppard

Hicks

Makambi

et al. 2016

Contemporary Clinical Trials

104

View full text Add to dashboard Cite

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“…women who did not undergo radiotherapy and/or chemotherapy probably had a higher risk of CVD at baseline. The lower risk of CVD in Asian populations [ 17 ] and the higher risk of CVD in black populations [ 6 ] are reported by several studies and can be explained by the lower and higher presence of CVD risk factors, respectively, such as high blood pressure, obesity, and lipid levels [ 39 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of death from cardiovascular disease following breast cancer: a systematic review

Gernaat

Rijnberg

et al. 2017

Breast Cancer Res Treat

164

122

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PurposeBreast cancer incidence and survival is high, which results in high prevalence of breast cancer survivors. The risk of (death from) cardiovascular disease (CVD) is higher in patients exposed to cardiotoxic treatments, in particular if they have pre-existing CVD risk factors. This study systematically summarized the risk of death from CVD following breast cancer.MethodsDatabases of Medline, Embase, and the Cochrane Library were systematically searched using the following terms and synonyms: breast cancer, cardiovascular disease, and cause of death. Articles reporting on both risk and risk factors of CVD mortality following breast cancer were eligible for inclusion. The methodological quality of each article was assessed using the Newcastle Ottawa quality assessment scale for cohort studies.ResultsFourteen articles were included assessing the risk of CVD mortality among 1,217,910 women with breast cancer. The methodological quality was high for the majority of the studies. Studies were heterogeneous in design, study population, length of follow-up, CVD outcomes, and risk factors. 1.6–10.4% of all women with breast cancer died of CVD. Women with breast cancer had a higher risk of CVD mortality than women from the general population. The risk of CVD mortality was higher among women with breast cancer with older age at diagnosis, left-sided tumor, diagnosis in an earlier calendar period, and black ethnic origin.ConclusionsCVD is an important cause of death following breast cancer. Identification of patients at high risk of CVD is important to optimize CVD prevention and tailor breast cancer treatment.

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African American Race Is a Correlate of Heart Failure in Breast Cancer Survivors: A Study of 26,347 Women Identified With Breast Cancer From 1973-2007

Cited by 2 publications

References 0 publications

The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study

The feasibility and acceptability of a diet and exercise trial in overweight and obese black breast cancer survivors: The Stepping STONE study

Risk of death from cardiovascular disease following breast cancer: a systematic review

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