African and Asian Medicinal Plants as a Repository for Prospective Antiviral Metabolites Against HIV-1 and SARS CoV-2: A Mini Review

Anywar, Godwin; Akram, Muhammad; Chishti, Muhammad Amjad

doi:10.3389/fphar.2021.703837

Cited by 6 publications

(6 citation statements)

References 79 publications

(98 reference statements)

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“…Many plant compounds have been analyzed through different approaches to explore their interacting potential with viral proteases [5]. Numerous medicinal plants are rich in flavonoids and polyphenolic chemicals that have been shown to have anti-protease efficacy against multiple infections like hepatitis, flu, HIV, cytomegalovirus, herpes, smallpox, and Ebola [19][20][21]. Their antiviral activity could involve inhibiting reverse transcriptase enzyme proteases and DNA polymerase.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Albiheyri,

Ahmad,

Khan

et al. 2024

Pharmaceuticals

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Background: The hunt for naturally occurring antiviral compounds to combat viral infection was expedited when COVID-19 and Ebola spread rapidly. Phytochemicals from Nyctanthes arbor-tristis Linn were evaluated as significant inhibitors of these viruses. Methods: Computational tools and techniques were used to assess the binding pattern of phytochemicals from Nyctanthes arbor-tristis Linn to Ebola virus VP35, SARS-CoV-2 protease, Nipah virus glycoprotein, and chikungunya virus. Results: Virtual screening and AutoDock analysis revealed that arborside-C, beta amyrin, and beta-sitosterol exhibited a substantial binding affinity for specific viral targets. The arborside-C and beta-sitosterol molecules were shown to have binding energies of −8.65 and −9.11 kcal/mol, respectively, when interacting with the major protease. Simultaneously, the medication remdesivir exhibited a control value of −6.18 kcal/mol. The measured affinity of phytochemicals for the other investigated targets was −7.52 for beta-amyrin against Ebola and −6.33 kcal/mol for nicotiflorin against Nipah virus targets. Additional molecular dynamics simulation (MDS) conducted on the molecules with significant antiviral potential, specifically the beta-amyrin-VP35 complex showing a stable RMSD pattern, yielded encouraging outcomes. Conclusions: Arborside-C, beta-sitosterol, beta-amyrin, and nicotiflorin could be established as excellent natural antiviral compounds derived from Nyctanthes arbor-tristis Linn. The virus-suppressing phytochemicals in this plant make it a compelling target for both in vitro and in vivo research in the future.

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Section: Discussionmentioning

confidence: 99%

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Albiheyri,

Ahmad,

Khan

et al. 2024

Pharmaceuticals

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“…The most prominent plant compounds with ligand-receptor modifying properties include lycorine, savinin, terpenoids, and various alkaloids (Oladele et al, 2020). The The medicinal plants that are commonly available and indigenous to the African countries (Anywar et al, 2021;Attah et al, 2021;Beressa et al, 2021).…”

Section: Mod Ifi C Ati On Of Hos T Cell Li G and Recep Tormentioning

confidence: 99%

“… a The medicinal plants that are commonly available and indigenous to the African countries (Anywar et al, 2021; Attah et al, 2021; Beressa et al., 2021). …”

Section: Mechanistic Aspects Of African Plant‐based Bioactives In Fig...mentioning

confidence: 99%

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Elegbeleye¹,

Krishnamoorthy

Bamidele

et al. 2022

Journal of Food Biochemistry

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The rural communities of the sub‐Sahara regions in Africa are rich in diverse indigenous culinary knowledge and foods, food crops, and condiments such as roots/tubers, cereal, legumes/pulses, locust beans, and green leafy vegetables. These food crops are rich in micronutrients and phytochemicals, which have the potentials to address hidden hunger as well as promote health when consumed. Some examples of these are fermented foods such as ogi and plants such as Vernonia amygdalina (bitter leaf), Zingiber officinales (garlic), Hibiscus sabdariffa (Roselle), and condiments. Food crops from West Africa contain numerous bioactive substances such as saponins, alkaloids, tannins, phenolics, flavonoids, and monoterpenoid chemicals among others. These bioresources have proven biological and pharmacological activities due to diverse mechanisms of action such as immunomodulatory, anti‐inflammatory, antipyretic, and antioxidant activities which made them suitable as candidates for nutraceuticals and pharma foods. This review seeks to explore the different processes such as fermentation applied during food preparation and food crops of West‐African origin with health‐promoting benefits. The different bioactive compounds present in such food or food crops are discussed extensively as well as the diverse application, especially regarding respiratory diseases. Practical applications The plants and herbs summarized here are more easily accessible and affordable by therapists and others having a passion for promising medicinal properties of African‐origin plants.The mechanisms and unique metabolic potentials of African food crops discussed in this article will promote their applicability as a template molecule for novel drug discoveries in treatment strategies for emerging diseases. This compilation of antiviral plants will help clinicians and researchers bring new preventive strategies in combating COVID‐19 like viral diseases, ultimately saving millions of affected people.

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“…The implementation of advanced plant cell and tissue culture systems, along with molecular biology techniques, has become not only the approach for new discoveries , but also the key for industrial production of secondary plant metabolites. , This is especially important considering that recent plant genome editing techniques depend on well-established in vitro culture and plant regeneration protocols.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Verbascoside Production from Olive (Olea europea L. var. Cellina di Nardò) In Vitro Cell Cultures

Blando,

Mita,

Di Sansebastiano

et al. 2024

J. Agric. Food Chem.

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Olive (Olea europea L.) is one of the oldest and most important fruit tree species cultivated in the Mediterranean region. Various plant tissues, drupes, and olive oil contain several phenolics (including verbascoside, although it is present in the plant at a low level) that are well-known for their highly beneficial effects on human health. An in vitro olive cell suspension culture (cultivar Cellina di Nardo, "CdN") was established, characterized for its growth and morphological features. Furthermore, a vital and relatively uniform population of protoplasts was generated from the olive suspension culture to investigate their cellular characteristics during growth. The polyphenolic extract of the in vitro "CdN" olive cells contained almost exclusively verbascoside, as revealed by the UPLC-ESI-MS analysis. The content of verbascoside reached up to 100 mg/g DW, with an average production rate of approximately 50 mg/g DW over one year of culture. This level of production has not been previously reported in a limited number of previous studies. This remarkable production of verbascoside was associated with an exceptionally high antioxidant capacity. The high level of verbascoside production and purity of the extract make this system a promising tool for secondary metabolite production.

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African and Asian Medicinal Plants as a Repository for Prospective Antiviral Metabolites Against HIV-1 and SARS CoV-2: A Mini Review

Cited by 6 publications

References 79 publications

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Highly Efficient Verbascoside Production from Olive (Olea europea L. var. Cellina di Nardò) In Vitro Cell Cultures

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