African genetic ancestry is associated with a protective effect on Dengue severity in colombian populations

Chacón-Duque, Juan Camilo; Adhikari, Kaustubh; Avendaño, Efren; Campo, Omer; Ramírez, Ruth; Rojas, Winston; Ruiz-Linares, Andrés; Restrepo, Berta Nelly; Bedoya, Gabriel

doi:10.1016/j.meegid.2014.07.003

Cited by 33 publications

(41 citation statements)

References 36 publications

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“…A recent study supports earlier findings suggesting that African ancestry protects against severe outcomes in dengue [69]. The most recent study was carried out in Colombia and looked at a population with European, Native American, or African ancestors.…”

Section: Surveillance and Warning Systemssupporting

confidence: 77%

Dengue: Update on Epidemiology

Wilson

Chen

2014

Curr Infect Dis Rep

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The epidemiology of dengue fever has undergone major shifts in recent decades. The global distribution has expanded to include more geographic areas. The intensity of transmission and the severity of infections have increased in areas where infection was already endemic. Multiple studies provide a clearer picture of the epidemiology and allow mapping of its distribution and change over time. Despite major efforts to control transmission, competent vectors now infest most tropical and subtropical regions; Aedes albopictus, also a competent vector, is able to survive in temperate areas, placing parts of Europe and North America at risk for local transmission. Many research teams in dengue-endemic areas are working to identify key local weather, vector, and other variables that would allow prediction of a likely epidemic early enough to permit interventions to avert it or blunt its impact.

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Section: Surveillance and Warning Systemssupporting

confidence: 77%

Dengue: Update on Epidemiology

Wilson

Chen

2014

Curr Infect Dis Rep

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“…Until recently, severe dengue had been reported infrequently in Africa (37). Previous studies showed decreased susceptibility to severe disease among the black population and suggested race may be host resistance factor to severe dengue (3839). These genetic factors may be associated with low incidence of DHF/DSS in Africa.…”

Section: Global Prevalencementioning

confidence: 99%

Epidemiological Characteristics and Risk Factors of Dengue Infection in Korean Travelers

Bae

Kim

et al. 2016

J Korean Med Sci

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Dengue viral infection has rapidly spread around the world in recent decades. In Korea, autochthonous cases of dengue fever have not been confirmed yet. However, imported dengue cases have been increased since 2001. The risk of developing severe dengue in Korean has been increased by the accumulation of past-infected persons with residual antibodies to dengue virus and the remarkable growth of traveling to endemic countries in Southeast Asia. Notably, most of imported dengue cases were identified from July to December, suggesting that traveling during rainy season of Southeast Asia is considered a risk factor for dengue infection. Analyzing national surveillance data from 2011 to 2015, males aged 20–29 years are considered as the highest risk group. But considering the age and gender distribution of travelers, age groups 10–49 except 20–29 years old males have similar risks for infection. To minimize a risk of dengue fever and severe dengue, travelers should consider regional and seasonal dengue situation. It is recommended to prevent from mosquito bites or to abstain from repetitive visit to endemic countries. In addition, more active surveillance system and monitoring the prevalence asymptomatic infection and virus serotypes are required to prevent severe dengue and indigenous dengue outbreak.

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“…Como se sabe que la composición genética individual puede influir en el riesgo de presentar formas graves del dengue (35), se puede considerar que una ventaja de este estudio fue haber controlado el análisis de asociación de polimorfismos génicos con información previa de los ancestros continentales, tal y como se ha recomendado para este tipo de estudios (39).…”

Section: Discussionunclassified

“…Por último, los fragmentos fueron resueltos en electroforesis con geles de agarosa al 2,5 %. (33)(34)(35). En general, estos se amplificaron mediante PCR, y tanto los polimorfismos de inserción y deleción como los que requirieron el uso de RFLP se resolvieron en electroforesis capilar (ABI-310) y en geles de agarosa.…”

Section: Extracción De Adn Y Tipificación De Variantes En Genes Candiunclassified

Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population

et al. 2017

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Introducción. La composición genética del huésped determina, entre otros aspectos, el perfil clínico del dengue, lo cual se debería al efecto de variantes en los genes que codifican citocinas proinflamatorias.Objetivo. Evaluar la asociación entre las variantes de tres polimorfismos en los genes candidatos TNFA, IL6 e IFNG con la gravedad del dengue en una población colombiana.Materiales y métodos. Se evaluaron los polimorfismos rs1800750, rs2069843 y rs2069705 de los genes TNFA, IL6 e IFNG, respectivamente, en 226 pacientes con dengue. Los genotipos se tipificaron usando la reacción en cadena de la polimerasa (PCR) y los polimorfismos de la longitud de los fragmentos de restricción (Restriction Fragment Length Polymorphism, RFLP). Para determinar el riesgo de diferentes fenotipos del dengue, se compararon las frecuencias alélicas con la prueba de ji al cuadrado, y los genotipos y los haplotipos, con regresión logística. Por último, los análisis se ajustaron utilizando datos de autoidentificación o del componente genético ancestral.Resultados. El alelo A del rs2069843, ajustado por autoidentificación, se asoció con casos de dengue hemorrágico en afrocolombianos. En la muestra completa, dicho polimorfismo, ajustado por componente genético ancestral, fue reproducible. Además, hubo asociaciones significativas entre las combinaciones alélicas GGT y GAC de los rs1800750, rs2069843 y rs2069705 en pacientes con dengue hemorrágico, con ajuste por componente genético ancestral y sin él. Además, la combinación alélica AGC produjo 58,03 pg/ml más de interleucina 6 que la GGC, independientemente de los componentes genéticos europeo, amerindio y africano.Conclusión. Las variantes de los polimorfismos GGT y GAC de los rs1800750, rs2069843 y rs2069705 en los genes TNFA, IL6 e IFNG, respectivamente, se correlacionaron con la gravedad del dengue en esta muestra de población colombiana.

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African genetic ancestry is associated with a protective effect on Dengue severity in colombian populations

Cited by 33 publications

References 36 publications

Dengue: Update on Epidemiology

Dengue: Update on Epidemiology

Epidemiological Characteristics and Risk Factors of Dengue Infection in Korean Travelers

Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population

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