African Medicinal Spices of Genus Piper

Oyemitan, Idris Ajayi

doi:10.1016/b978-0-12-809286-6.00027-3

Cited by 22 publications

(15 citation statements)

References 51 publications

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“…ere is therefore an urgent need to find new effective, low-toxicity substances, and given that phytochemicals are a poorly explored field makes it an unexplored gold mine for researchers. Piper capense is a food plant used in Cameroon and other countries in the world in the preparation of dishes and also for its therapeutic virtues [46,47].…”

Section: Discussionmentioning

confidence: 99%

Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Wamba

Ghosh

Mbaveng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Piper capense belongs to Piperaceae family and has long been used as a traditional medicine to treat various diseases in several parts of Africa. The present study aims to investigate the effect of Piper capense fruit extract (PCFE) alone and in combination with dacarbazine on metastatic melanoma cell line B16-F10 and in vivo in C57BL/6J mice. Cytotoxic effects of PCFE alone and in association with dacarbazine on B16-F10 cells were studied by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and colony formation assay. Wound healing assay, immunofluorescence staining, and western blot analysis were performed to evaluate the individual and combined effect of PCFE and dacarbazine on epithelial-mesenchymal transition (EMT). For in vivo studies, C57BL/6J mice were subcutaneously injected with B16-F10 cells (5 × 105 cells/mL), and the effect of PCFE and dacarbazine was studied on tumor development. The alteration of EMT was evaluated by targeting E-cadherin, vimentin, and CD133 in PCFE alone and in combination with dacarbazine-treated tumor tissues by western blot analysis. Phytochemical screening of PCFE reveals the presence of certain secondary metabolites. Our results showed that PCFE alone and in association with dacarbazine has a good activity in preventing B16-F10 melanoma cell progression and clonogenicity. This extract also regulated EMT. In vivo results showed that PCFE (100 mg/kg body weight) reduced tumor size in C57BL/6J mice along with the decrease in the expression of vasculogenic mimicry (VM) tubes as well as an improvement in the qualitative and quantitative expression of markers involved in EMT. Our study suggests that PCFE may be useful for managing the growth and metastasis of melanoma.

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Section: Discussionmentioning

confidence: 99%

Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Wamba

Ghosh

Mbaveng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The plant is widely distributed in the tropical regions of central and western Africa and can be found countries such as Nigeria, Guinea, Ghana and Uganda. It grows in closed forests, forest edges and generally wet places in forests clearings (Burkill et al 1985;Oyemitan 2017).…”

Section: Origin Habitat and Distribution Of Piper Guineensementioning

confidence: 99%

Ethnomedicinal Uses and Therapeutic Activities of Piper Guineense: A Review

Alagbe¹,

Alagbe²,

Adekunle³

et al. 2021

jasem

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The use of medicinal plants in most developing countries as therapeutic agents for the maintenance of good health is a widespread practice. One of such plant products is Piper guineense, which is a West African spice used in many folklore medicines and has a number of verified pharmacological activities. Proximate analysis reveals that the plant contains crude protein, fat, carbohydrate, vitamins and minerals while preliminary phytochemical screening and gas chromatography-mass spectrophotoscopy of the methanol leaf and seed extract of Piper guineense revealed the presence of several constituents such as alkaloids, glycosides, tannins, flavonoids, terpenes; sesquiterpenoids and monoterpenoids, saponins and secondary metabolites such as Aromadendrene, 1,6,10- Dodecatriene,7,11-dimethyl-3-methylene and piperine, piperidine amongst other secondary metabolites. Studies have revealed that Piper guineense possess several pharmacological and therapeutic properties such as anti-oxidant, anti-microbial, aphrodisiac, anti-parasitic, antiinflammatory, anti-convulsant, molluscicidal, oestrogenic and oxytocic properties. This paper provides a review on the morphology, physicochemical and phytochemical constituents, ethnomedicinal and scientifically proven therapeutic activities of Piper guineense.

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“…and P. capense L. f., which are widespread across many African countries. Piper guineense, otherwise known as West African black pepper, originates from West Africa and compares favourably with black pepper (P. nigrum) as a flavouring for food (Oyemitan, 2017).…”

Section: Introductionmentioning

confidence: 99%

<em>Piper</em> species (Piperaceae) of Sri Lanka and the diversity of the economically important <em>Piper nigrum</em> (black pepper): An overview of what has been done and what is yet to be achieved

et al. 2022

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Highlights• Piper L. (Piperaceae) is one of the most diverse genera among the basal clades of angiosperms.• Available chromosome counts indicate that most wild species are diploids and cultivated species are tetraploids.• Next generation based restriction-site-associated DNA sequencing (RADseq) is a promising genomic tool that could be used to investigate species delimitation and genetic variation within the economically important Piper nigrum (black pepper).• Three-dimensional (3D) floral morphology imaging using computed tomography will aid in the taxonomic revision and understanding pollination biology of this genus.

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African Medicinal Spices of Genus Piper

Cited by 22 publications

References 51 publications

Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies

Ethnomedicinal Uses and Therapeutic Activities of Piper Guineense: A Review

<em>Piper</em> species (Piperaceae) of Sri Lanka and the diversity of the economically important <em>Piper nigrum</em> (black pepper): An overview of what has been done and what is yet to be achieved

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