African Plants with Dermatological and Ocular Relevance

Twilley, Danielle; Lall, Namrita

doi:10.1016/b978-0-12-800018-2.00016-9

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…Studies have suggested that phenolic substances have protective effects on cell membranes by decreasing lipid peroxidation and removing free radicals ( Chaudhuri et al, 2007 ). A study has claimed that both honey bee honey (HBH) and SBH can counteract reactive oxygen species (ROS; Twilley and Lall, 2014 ), whereby the phenolic acid extracted from SBH can reduce the production of ROS ( Borsato et al, 2014 ). Kaempferol can inhibit the effects of free radicals, including NO synthase (NOS) and cyclooxygenase-2 (COX-2; Crespo et al, 2008 ).…”

Section: Phytochemical Compounds Found In Sbh and Their Potential Neu...mentioning

confidence: 99%

The potential neuroprotective effects of stingless bee honey

Zulkifli

Hassan

Mustafa

et al. 2023

Front. Aging Neurosci.

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Tropical Meliponini bees produce stingless bee honey (SBH). Studies have shown beneficial properties, including antibacterial, bacteriostatic, anti-inflammatory, neurotherapeutic, neuroprotective, wound, and sunburn healing capabilities. High phenolic acid and flavonoid concentrations offer SBH its benefits. SBH can include flavonoids, phenolic acids, ascorbic acid, tocopherol, organic acids, amino acids, and protein, depending on its botanical and geographic origins. Ursolic acid, p-coumaric acid, and gallic acid may diminish apoptotic signals in neuronal cells, such as nuclear morphological alterations and DNA fragmentation. Antioxidant activity minimizes reactive oxygen species (ROS) formation and lowers oxidative stress, inhibiting inflammation by decreasing enzymes generated during inflammation. Flavonoids in honey reduce neuroinflammation by decreasing proinflammatory cytokine and free radical production. Phytochemical components in honey, such as luteolin and phenylalanine, may aid neurological problems. A dietary amino acid, phenylalanine, may improve memory by functioning on brain-derived neurotrophic factor (BDNF) pathways. Neurotrophin BDNF binds to its major receptor, TrkB, and stimulates downstream signaling cascades, which are crucial for neurogenesis and synaptic plasticity. Through BDNF, SBH can stimulate synaptic plasticity and synaptogenesis, promoting learning and memory. Moreover, BDNF contributes to the adult brain’s lasting structural and functional changes during limbic epileptogenesis by acting through the cognate receptor tyrosine receptor kinase B (TrkB). Given the higher antioxidants activity of SBH than the Apis sp. honey, it may be more therapeutically helpful. There is minimal research on SBH’s neuroprotective effects, and the related pathways contribute to it is unclear. More research is needed to elucidate the underlying molecular process of SBH on BDNF/TrkB pathways in producing neuroprotective effects.

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Section: Phytochemical Compounds Found In Sbh and Their Potential Neu...mentioning

confidence: 99%

The potential neuroprotective effects of stingless bee honey

Zulkifli

Hassan

Mustafa

et al. 2023

Front. Aging Neurosci.

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“…Reactive oxygen species (ROS) are the causer of oxidative stresses that lead to various diseases and disorders such as cardiovascular disease and cancer. 9 Several studies have claimed that both honey bee honey (HBH) and stingless bee honey (SBH) are very effective in combating ROS and are one of the best antioxidant sources that can be acquired naturally. 10,11 A thorough understanding of the characteristics of honey is also required for commercialization.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Stingless Bee Honey and Honeybee Honey Characteristics in Relation to Anticancer Potential

Yusof

Zulpa

Isa

et al. 2021

imjm

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Introduction: The composition of the honey depends on the intrinsic and extrinsic factors, including place of origin, the floral types, the season and the storage conditions. This study compared the anticancer potential, quality, antioxidant and phytochemical between unprocessed stingless bee honey (SBH) and honeybee honey (HBH) from the same environmental factors including place of nest, floral type (Acacia), harvesting month (August) and storage conditions (<5°C). Materials and methods: To measure quality, 5-hydroxymethylfurfural (HMF) and diastase activity were determined, followed by total phenolic content (TPC) and total flavonoid content (TFC) for phytochemicals. Antioxidant activity was assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Cytotoxicity towards cervical cancer cell line (HeLa) was measured using a 2-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay (IC50). Results: The results indicated that HBH exhibited significantly higher diastase activity (2.17 ± 0.07 DN), TPC (338.95 ± 3.49 mg GAE/kg), DPPH scavenging activity EC50 (80.06 mg/ml) and MTT activity IC50 (64.80 mg/ml) towards HeLa as compared to SBH with absence of diastase activity, TPC (250.60 ± 3.98 mg GAE/kg), DPPH scavenging activity EC50 (165.80 mg/ml) and MTT activity IC50 (75.76 mg/ml). However, there were no significant differences in HMF and TFC between HBH and SBH. Conclusion: Therefore, the present study found that HBH demonstrates better antioxidant capacity, anticancer potential and phenolic content as compared to SBH.

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“…Botanicals and natural ingredients provide abundant sources of treatment for various diseases such as cancer, diabetes, and dermatological conditions [31,32]. The use of plants is a common practice in traditional medicines of many cultures using several plant extracts as cosmetics to improve skin health [33,34]. This could be attributed to plant extracts being a rich source of vitamins, antioxidants, oils/essential oils, and other bioactive compounds, which provide the body with nutrients necessary for healthy skin [30].…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review

et al. 2020

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The indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative effects associated with skin lightener toxicity. For this reason, there is a growing interest in the cosmetic development of plants and their metabolites as alternatives to available chemical-derived skin lightening formulations. Approximately 90% of Africa’s population depends on traditional medicine, and the continent’s biodiversity holds plant material with various biological activities, thus attracting considerable research interest. This study aimed to review existing evidence and document indigenous African plant species capable of inhibiting the enzyme tyrosinase and melanogenesis for potential incorporation into skin lightening products. Literature search on melanin biosynthesis, skin lightening, and tyrosinase inhibitors resulted in the identification of 35 plant species were distributed among 31 genera and 21 families across 15 African countries and 9 South African provinces. All plants identified in this study showed competent tyrosinase and melanogenesis inhibitory capabilities. These results indicate that African plants have the potential to serve as alternatives to current chemically-derived skin lighteners.

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African Plants with Dermatological and Ocular Relevance

Cited by 6 publications

References 43 publications

The potential neuroprotective effects of stingless bee honey

The potential neuroprotective effects of stingless bee honey

Stingless Bee Honey and Honeybee Honey Characteristics in Relation to Anticancer Potential

Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review

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