African Swine Fever Virus (Asfarviridae)

Dixon, Lucas; Nash, Rachel; Hawes, Philippa C.; Netherton, Christopher L.

doi:10.1016/b978-0-12-809633-8.20925-4

Cited by 1 publication

(1 citation statement)

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“…Thus, the KV lineage emerged at a strategic phylogenetic position for the understanding of this important viral clade, which includes the African swine fever virus (ASFV) [13]. This latter is the cause of African swine fever, an important disease that remains a serious threat to swine industries worldwide [14]. Although FV-E12 had a larger genome than KV-Sc (466 Kb vs. 351 Kb, respectively), both viruses encoded a similar number of genes (451 vs. 465 respectively).…”

Section: Introductionmentioning

confidence: 99%

The Kaumoebavirus LCC10 Genome Reveals a Unique Gene Strand Bias among “Extended Asfarviridae”

Geballa-Koukoulas

Andréani

Scola

et al. 2021

Viruses

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Kaumoebavirus infects the amoeba Vermamoeba vermiformis and has recently been described as a distant relative of the African swine fever virus. To characterize the diversity and evolution of this novel viral genus, we report here on the isolation and genome sequencing of a second strain of Kaumoebavirus, namely LCC10. Detailed analysis of the sequencing data suggested that its 362-Kb genome is linear with covalently closed hairpin termini, so that DNA forms a single continuous polynucleotide chain. Comparative genomic analysis indicated that although the two sequenced Kaumoebavirus strains share extensive gene collinearity, 180 predicted genes were either gained or lost in only one genome. As already observed in another distant relative, i.e., Faustovirus, which infects the same host, the center and extremities of the Kaumoebavirus genome exhibited a higher rate of sequence divergence and the major capsid protein gene was colonized by type-I introns. A possible role of the Vermamoeba host in the genesis of these evolutionary traits is hypothesized. The Kaumoebavirus genome exhibited a significant gene strand bias over the two-third of genome length, a feature not seen in the other members of the “extended Asfarviridae” clade. We suggest that this gene strand bias was induced by a putative single origin of DNA replication located near the genome extremity that imparted a selective force favoring the genes positioned on the leading strand.

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Section: Introductionmentioning

confidence: 99%