African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities

Lai, Danh Cong; Chaudhari, Jayeshbhai; Vu, Hiep L.X.

doi:10.1016/j.virusres.2024.199342

Virus Research

2024

DOI: 10.1016/j.virusres.2024.199342

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African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities

Danh Cong Lai,

Jayeshbhai Chaudhari,

Hiep L.X. Vu

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2024

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Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

Venkateswaran,

Prakash,

Nguyen

et al. 2024

Animals

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African Swine Fever (ASF) is a lethal contagious hemorrhagic viral disease affecting the swine population. The causative agent is African Swine Fever Virus (ASFV). There is no treatment or commercial vaccine available at present. This virus poses a significant threat to the global swine industry and economy, with 100% mortality rate in acute cases. ASFV transmission occurs through both direct and indirect contact, with control measures limited to early detection, isolation, and culling of infected pigs. ASFV exhibits a complex genomic structure and encodes for more than 50 structural and 100 non-structural proteins and has 150 to 167 open reading frames (ORFs). While many of the proteins are non-essential for viral replication, they play crucial roles in mediating with the host to ensure longevity and transmission of virus in the host. The dynamic nature of ASFV research necessitates constant updates, with ongoing exploration of various genes and their functions, vaccine development, and other ASF-related domains. This comprehensive review aims to elucidate the structural and functional roles of both newly discovered and previously recorded genes involved in distinct stages of ASFV infection and immunomodulation. Additionally, the review discusses the virulence genes and genes with unknown functions, and proposes future interventions.

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Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

Venkateswaran,

Prakash,

Nguyen

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

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African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities

Cited by 1 publication

References 41 publications

Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

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