What should be the politics of Afrocentricity? How should Afrocentrists fight globalization's empire, the continuation of slavery by other means? This article grounds political resistance to empire in an ancient Egyptian philosophy of holism. The article's theme is that four powerful movements are converging on a new philosophy. Paradoxically, this “new” philosophy is prefigured in the oldest recorded philosophy, that of ancient Egypt. The four converging philosophies are Afrocentricity, ecofeminism, deep ecology or radical environmentalism, and Marxism. These movements are contemporary expressions of resistance to centuries if not millennia of violent oppression. The article's aim is to create a synergy among these movements to build a coalition that can challenge empire. The article briefly examines the historical career of holism in the area of ontology before considering expressions of holism in the areas of ethics and politics.