After-exercise heart rate variability is attenuated in postmenopausal women and unaffected by estrogen therapy

Harvey, Paula; O’Donnell, Emma; Picton, Peter; Morris, Beverley L.; Notarius, Catherine F.; Floras, John S.

doi:10.1097/gme.0000000000000568

Cited by 10 publications

(14 citation statements)

References 43 publications

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“…Therefore, the CRP and HRV values were analyzed with and without the participants who were on HT. Previous research from Harvey et al (2015) reported a lack of improvement in HRV following estrogen therapy 17 . Chi square was used to determine group differences for HT.…”

Section: Methodsmentioning

confidence: 92%

Is Vigorous Exercise Training Superior to Moderate for CVD Risk after Menopause?

Orri

Hughes

Mistry

et al. 2017

Sports Med Int Open

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Postmenopausal women have an increased risk for cardiovascular disease through many factors, such as a sedentary lifestyle and reduced heart rate variability (HRV). Endurance training improves coronary risk but the role of exercise intensity is unclear. The purpose of this observational study was to evaluate the effects of moderate versus vigorous exercise on cardiovascular disease risk in postmenopausal women. Thirty-six postmenopausal women who self-reported training at moderate (3–5.9 METS; n=18; age 58.9±4.4yr) or vigorous intensities (>6 METS; n=18; age 59.7±5.2yr) participated. C-reactive protein (CRP), HRV, VO 2 max, and stress (Perceived Stress Survey, Menopause Rating Scale) were measured. Groups were compared using independent samples t- tests, and associations of exercise intensities with CRP and HRV were assessed using multiple regression. CRP, HRV, and VO 2 max were similar ( p >0.05). Vigorous exercise had lower stress subscale scores ( p <0.01) and higher counter-stress subscale scores compared to moderate ( p <0.05). There was a positive association between time spent in vigorous exercise and HRV ( p <0.05).Vigorous exercise may not confer additional benefits in CRP and HRV over moderate, except for stress reduction. However, more time spent in vigorous exercise was associated with higher HRV. Therefore, increased parasympathetic tone may provide cardioprotection after menopause.

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Section: Methodsmentioning

confidence: 92%

Is Vigorous Exercise Training Superior to Moderate for CVD Risk after Menopause?

Orri

Hughes

Mistry

et al. 2017

Sports Med Int Open

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show abstract

“…Studies have verified that aging and decreased estrogen levels are related to autonomic nervous changes of postmenopausal women [20], whereas some studies have not shown that estrogen therapy has a significant effect on heart rate variability (HRV) of postmenopausal women [21,22]. HRV is a simple and non-invasive tool for describing fluctuations between continuous heartbeat intervals (RR intervals) that can be used to identify phenomena associated with the autonomic nervous system [23].…”

Section: Introductionmentioning

confidence: 99%

Royal Jelly Ameliorates Behavioral Deficits, Cholinergic System Deficiency, and Autonomic Nervous Dysfunction in Ovariectomized Cholesterol-Fed Rabbits

Pan

Jin

et al. 2019

Molecules

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Estrogen deficiency after menopause is associated with autonomic nervous changes, leading to memory impairment and increased susceptibility to Alzheimer’s disease (AD). Royal jelly (RJ) from honeybees (Apis mellifera) has estrogenic activity. Here, we investigated whether RJ can improve behavior, cholinergic and autonomic nervous function in ovariectomized (OVX) cholesterol-fed rabbits. OVX rabbits on high-cholesterol diet were administered with RJ for 12 weeks. The results showed that RJ could significantly improve the behavioral deficits of OVX cholesterol-fed rabbits and image structure of the brain. RJ reduced body weight, blood lipid, as well as the levels of amyloid-beta (Aβ), acetylcholinesterase (AchE), and malonaldehyde (MDA) in the brain. Moreover, RJ also increased the activities of choline acetyltransferase (ChAT) and superoxide dismutase (SOD) in the brain, and enhanced heart rate variability (HRV) and Baroreflex sensitivity (BRS) in OVX cholesterol-fed rabbits. Furthermore, RJ was also shown to reduce the content of Evans blue and the expression levels of Aβ, beta-site APP cleaving enzyme 1(BACE1), and receptor for advanced glycation end products (RAGE), and increase the expression level of LDL(low density lipoprotein) receptor-related protein 1 (LRP-1) in the brain. Our findings suggested that RJ has beneficial effects in neurological disorders of postmenopausal women, which were associated with reducing cholesterol and Aβ deposition, enhancing the estrogen levels and the activities of cholinergic and antioxidant systems, and ameliorating the blood–brain barrier (BBB) permeability and restoring autonomic nervous system.

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“…Moreover, clinical studies have observed impaired autonomic modulation of the cardiovascular system by HRV in postmenopausal women when compared to premenopausal women [31][32][33]. It has been suggested that the reduced sympathetic tone in premenopausal women may contribute to help promote cardiovascular protection [34].…”

Section: Discussionmentioning

confidence: 99%

Ovarian status modulates cardiovascular autonomic control and oxidative stress in target organs

et al. 2020

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Studies have presented conflicting findings regarding the association between both fluctuation and deprivation of ovarian hormones and cardiovascular autonomic modulation and oxidative stress and their potential impact on resting arterial pressure (AP) and cardiovascular risk. This study aimed to assess cardiovascular autonomic modulation, baroreflex sensitivity (BRS), and oxidative stress in male rats (M) and in female rats during ovulatory (FOV) and non-ovulatory phases (FNOV) of the estrous cycle and after deprivation of ovarian hormones (FO). Direct AP was recorded, and BRS was assessed by using increasing doses of phenylephrine and sodium nitroprusside. AP and heart rate variability were assessed by spectral analysis. Oxidative stress profile was evaluated in cardiac, renal, and muscle tissues. In females, the ovulatory phase and ovarian hormone deprivation induced an increase in AP (FOV and FO~9 mmHg) when compared to the non-ovulatory phase. Ovariectomy promoted increased cardiac sympathovagal balance (~17-37%) when compared to other groups. Both FOV and FO groups presented impaired BRS, associated with higher AP variability. In general, antioxidant capacity was higher in the FNOV than in the M group. Ovarian hormone deprivation induced a decrease in catalase activity in cardiac and renal tissues and an increase in lipid peroxidation in all tissues analyzed. Positive correlations (p < 0.05) were found between vascular sympathetic modulation and lipid peroxidation in cardiac (r = 0.60), renal (r = 0.60), and muscle (r = 0.57) tissues. In conclusion, both oscillation and deprivation of ovarian hormones play an important role in cardiovascular autonomic control and oxidative stress profile in target organs, which is reflected in AP changes.

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After-exercise heart rate variability is attenuated in postmenopausal women and unaffected by estrogen therapy

Cited by 10 publications

References 43 publications

Is Vigorous Exercise Training Superior to Moderate for CVD Risk after Menopause?

Is Vigorous Exercise Training Superior to Moderate for CVD Risk after Menopause?

Royal Jelly Ameliorates Behavioral Deficits, Cholinergic System Deficiency, and Autonomic Nervous Dysfunction in Ovariectomized Cholesterol-Fed Rabbits

Ovarian status modulates cardiovascular autonomic control and oxidative stress in target organs

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