Mycotoxins are fungal metabolites that commonly contaminate food crops such as maize. Conducive climatic conditions together with improper crop value chain practices are favorable for mycotoxin contamination. Previous studies in Ethiopia have indicated that mycotoxin contamination in maize is prevalent. For the implementation of proper mycotoxin prevention and control strategies, identifying the current local value chain practices that are related to mycotoxin contamination is needed. This review investigates current preharvest and postharvest management practices of maize cultivation in Ethiopia in relation to mycotoxin contamination and identifies gaps in knowledge and priority areas for future research. Findings indicate that the majority of applied preharvest and postharvest practices of maize in Ethiopia seem to favor mycotoxin contamination. Recent developments in grain drying and storage technologies, which are also potential mycotoxin management strategies, are facing constraints for proper implementation in subsistence farmers’ level.