Afterload Sensitivity of Nonlinear End-Systolic Pressure–Volume Relation vs Preload Recruitable Stroke Work in Conscious Dogs

McClain, Lucinda; Wright, Leon D.; Bose, Raj; Spratt, John A.; Maier, G. W.

doi:10.1006/jsre.1997.5024

Cited by 15 publications

(17 citation statements)

References 18 publications

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“…10 heart cycles were calculated with the model and the result of the last cycle was evaluated. The calculation time step [10]. Corresponding pressure volume loops are presented in Figure 8.…”

Section: E Xperimental Resultsmentioning

confidence: 99%

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An approximation model of myocardial crossbridge for weak coupling calculation of left ventricle model and circulation model

Amano

Takada

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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It is necessary to use complicated myocardial cell model and heart model to evaluate the regional energy production and consumption which leads to the unrealistic computational time. In this research, a left ventricle (LV) simulation model was constructed which includes accurate myocardial cell model. In order to simulate the model in realistic time, we introduced an approximation model of the crossbridge model which can be calculated with weak coupling calculation. The LV model was combined with a circulation model to validate the proposed model by calculating the hemodynamics parameters and ventricular energetics indices. The ESPVR (End Systolic Pressure Volume Relation) showed linear relation, and also the PVA - ATP consumption relation showed linear relation which are widely known as the physiological characteristics of mammalian hearts. From these results, we can say that the model can be used as a model for physiological simulation experiments which are related to the ventricular energetics.

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Section: E Xperimental Resultsmentioning

confidence: 99%

“…The preload (E v ) was set to 4.0, 7.0, 10.0 [mmHg] according to the published physiological values [10]. 10 heart cycles were calculated with the model and the result of the last cycle was evaluated.…”

Section: E Xperimental Resultsmentioning

confidence: 99%

An approximation model of myocardial crossbridge for weak coupling calculation of left ventricle model and circulation model

Amano

Takada

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…Despite the remarkable progress in cardiovascular research, the accurate (non-invasive) quantification of left ventricular (LV) contractile function remains a major challenge in clinical practice. As such, many studies have focused on identifying the best possible index of LV contractility taking into account its load dependency, its sensitivity to inotropic and chronotropic state and its reproducibility [1][2][3][4][5][6][7][8][9][10][11].Currently, the slope (E max ) of the end systolic pressure volume relationship (ESPVR) and the preload recruitable stroke work (PRSW) are considered the gold standards measurements of LV contractility. Additionally, the slope of the dP/dt max -end diastolic volume (EDV) relationship is also commonly used as an estimate of LV contractility.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the slope of the dP/dt max -end diastolic volume (EDV) relationship is also commonly used as an estimate of LV contractility. All these measurements are based on the Frank-Starling law of the heart that describes a direct relation between preload and the active force developed by the ventricle [1][2][3][4][5]8]. Available data from experimental studies on mammals and humans points towards PRSW as the most reliable index due to its load independency, its sensitivity to contractile changes and its low measurement variability [1,3,5,6,7,9].…”

Section: Introductionmentioning

confidence: 99%

“…All these measurements are based on the Frank-Starling law of the heart that describes a direct relation between preload and the active force developed by the ventricle [1][2][3][4][5]8]. Available data from experimental studies on mammals and humans points towards PRSW as the most reliable index due to its load independency, its sensitivity to contractile changes and its low measurement variability [1,3,5,6,7,9]. In contrast, the maximal slope of the dP/dt max -EDV relationship was reported to be load dependent and sensitive to measurement variability while data on E max is contradictory, with some studies reporting a degree of load dependency and non-linearity of the measurement under non-physiologic conditions while others do not [1][2][3][4][5][6][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility

et al. 2020

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BackgroundThe slope of the relationship between segmental PreS and total systolic shortening (S) has been proposed as a non-invasive index of left ventricular contractility. The aim of this study was to correlate this novel parameter to invasive gold standard measurements of contractility and to investigate how it is influenced by afterload. OPEN ACCESS Citation: Mirea O, Vallecilla C, Claus P, Rademakers F, D'hooge J (2020) Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility. PLoS ONE 15(2): e0228027. https:// ConclusionsThe slope of the PreS-S relationship is sensitive to changes in inotropy and is less loaddependent than conventional non-invasive parameters of left ventricular function. The magnitude of the change of this slope correlates well with changes in invasive contractility measurements making it an attractive parameter to assess contractile reserve or contractile changes during longitudinal follow-up of patients.Validation of the prestretch-strain relationship as an index of left ventricular contractility PLOS ONE | https://doi.

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Modification of ventriculo–arterial coupling by spironolactone in nonischemic dilated cardiomyopathy

et al. 2021

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Aims We sought to clarify the role of ventriculo-arterial (V-A) coupling in the treatment of nonischemic dilated cardiomyopathy (NIDCM) by adding a mineralocorticoid receptor antagonist (MRA) to conventional anti-failure therapy. Methods and results We employed cardiac magnetic resonance imaging to quantify left ventricular (LV) contractility and V-A coupling in normal subjects at rest (n = 11) and in patients with NIDCM (n = 12) before and after long term anti-failure therapy, in which MRA was added to conventional anti-failure therapy. After ≥6 months' treatment in NIDCM patients, LV volumes and mass decreased, and the LV ejection fraction increased from a median of 24% (17, 27) (interquartile range IQR) to 47 (42, 52) (P < 0.002), with a marked reduction in arterial elastance (Ea) from 2.89 mmHg/mL (2.34, 4.0) to 1.50 (1.29, 1.95) (P < 0.002), similar to Ea of normal subjects, 1.53 (1.34, 1.67) (P > 0.05). The V-A coupling ratio, Ea/end-systolic elastance (single-beat method), decreased by À1.08 (À1.96, À0.55), (P = 0.003), as did Ea/end-systolic pressure/end-systolic pressure ratio, À0.54 (0.35, 0.87), (P = 0.002). The preload recruitable stroke work (PRSW) increased as did PRSW indexed for Ea (both P = 0.002), which reflected 'total circulatory performance'. Conclusions In NIDCM, adding MRA to conventional anti-failure therapy markedly improved LV ejection fraction and reduced peripheral vascular resistance, due to both improved LV contractility and especially to enhanced V-A coupling, as Ea decreased to normal. Total circulatory performance was a sensitive indicator of both LV pump performance and the arterial loading conditions.

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Afterload Sensitivity of Nonlinear End-Systolic Pressure–Volume Relation vs Preload Recruitable Stroke Work in Conscious Dogs

Cited by 15 publications

References 18 publications

An approximation model of myocardial crossbridge for weak coupling calculation of left ventricle model and circulation model

An approximation model of myocardial crossbridge for weak coupling calculation of left ventricle model and circulation model

Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility

Modification of ventriculo–arterial coupling by spironolactone in nonischemic dilated cardiomyopathy

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