Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics

Darabdhara, Gitashree; Das, Manash R.; Singh, Surya Prakash; Rengan, Aravind Kumar; Szunerits, Sabine; Boukherroub, Rabah

doi:10.1016/j.cis.2019.101991

Cited by 132 publications

(56 citation statements)

References 286 publications

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“…A recent review suggested that Ag-RGO and Au-RGO nanocomposites have shown potential to be applied in drug delivery, cancer therapy, and biosensors [54]. The equilibrium between pro-oxidant generation and their scavenging by antioxidant molecules and enzymes is a delicate phenomenon.…”

Section: Oxidative Stressmentioning

confidence: 99%

Evaluation of the Cytotoxicity and Oxidative Stress Response of CeO2-RGO Nanocomposites in Human Lung Epithelial A549 Cells

et al. 2019

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Graphene-based nanocomposites have attracted enormous interest in nanomedicine and environmental remediation, owing to their unique characteristics. The increased production and widespread application of these nanocomposites might raise concern about their adverse health effects. In this study, for the first time, we examine the cytotoxicity and oxidative stress response of a relatively new nanocomposite of cerium oxide-reduced graphene oxide (CeO2-RGO) in human lung epithelial (A549) cells. CeO2-RGO nanocomposites and RGO were prepared by a simple hydrothermal method and characterized by relevant analytical techniques. Cytotoxicity data have shown that RGO significantly induces toxicity in A549 cells, evident by cell viability reduction, membrane damage, cell cycle arrest, and mitochondrial membrane potential loss. However, CeO2-RGO nanocomposites did not cause statistically significant toxicity as compared to a control. We further observed that RGO significantly induces reactive oxygen species generation and reduces glutathione levels. However, CeO2-RGO nanocomposites did not induce oxidative stress in A549 cells. Interestingly, we observed that CeO2 nanoparticles (NPs) alone significantly increase glutathione (GSH) levels in A549 cells as compared to a control. The GSH replenishing potential of CeO2 nanoparticles could be one of the possible reasons for the biocompatible nature of CeO2-RGO nanocomposites. Our data warrant further and more advanced research to explore the biocompatibility/safety mechanisms of CeO2-RGO nanocomposites in different cell lines and animal models.

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Section: Oxidative Stressmentioning

confidence: 99%

Evaluation of the Cytotoxicity and Oxidative Stress Response of CeO2-RGO Nanocomposites in Human Lung Epithelial A549 Cells

et al. 2019

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“…Nanoparticles have a diameter between 1 and 100 nm, have specific characteristics such as regular morphology, and are smaller than bulk structures . Drug delivery, catalysis, artificial implants, sensing, photonics, diagnostics, imaging, and tissue engineering are some of the prominent applications of metallic nanoparticles …”

Section: Introductionmentioning

confidence: 99%

“…[5] Drug delivery, catalysis, artificial implants, sensing, photonics, diagnostics, imaging, and tissue engineering are some of the prominent applications of metallic nanoparticles. [6][7][8][9][10][11][12] Compounds in factory wastewater such as organic contaminants cause hazards to human health and living creatures. In recent years, the increase in population growth has led to many industrial changes, which, in turn, has led to a sharp decline in natural resources.…”

Section: Introductionmentioning

confidence: 99%

Novel NiFe/Si/Au magnetic nanocatalyst: Biogenic synthesis, efficient and reusable catalyst with enhanced visible light photocatalytic degradation and antibacterial activity

Shirzadi‐Ahodashti

Ebrahimzadeh

Amiri

et al. 2020

Applied Organom Chemis

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The aim of this paper is to biosynthesize NiFe2O4/SiO2/Au (NiFe/Si/Au) magnetic nanocatalyst using the sonochemical method. This is the first study to synthesize this compound using this method. To obtain optimum morphology and size of products, the synthesis was performed in the presence of polyvinylpyrrolidone, maltose, glucose, and fructose as capping agents and Crataegus pentagyna leaf extract and NaBH4 as reducing agents. Vibrating‐sample magnetometer, field‐emission scanning electron microscopy, Fourier‐transform infrared, transmission electron microscopy, X‐ray diffraction, energy‐dispersive X‐ray spectroscopy, and differential reflectance spectroscopy techniques were performed to confirm the preparation of magnetic products. The as‐synthesized magnetic samples were used to enhance the photocatalytic degradation and antibacterial activity. The NiFe/Si/Au nanocatalysts exhibited an excellent photocatalytic activity by degradation of rhodamine b, methylene blue, and erythrosine as organic contaminants under ultraviolet and visible light irradiation. The degradation curves illustrate that the degradation of anionic dyes is more than that of cationic dyes. In addition, antibacterial activity of as‐prepared nanocatalyst against seven bacterial species was investigated. Because of their antibacterial effects, as‐synthesized products show a high antibacterial activity against various bacteria. Consequently, the NiFe/Si/Au nanocatalysts with high antibacterial activity and excellent potential photocatalyst activity can be used in environmental and medical sciences for wastewater treatment.

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“…The GO and RGO contains a large number of residual oxygen functional groups with a large number of surface defects. The oxygen functional groups and surface defects are very reactive and can be utilized in developing advanced GO/RGO-based nanocomposites that are useful in numerous applications including imaging, targeted drug delivery, and cancer therapy [7,8].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Cytotoxicity, Apoptosis, and Oxidative Stress Response of Fe3O4-RGO Nanocomposites in Human Liver HepG2 cells

2020

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Iron oxide–reduced graphene oxide (Fe3O4-RGO) nanocomposites have attracted enormous interest in the biomedical field. However, studies on biological response of Fe3O4-RGO nanocomposites at the cellular and molecular level are scarce. This study was designed to synthesize, characterize, and explore the cytotoxicity of Fe3O4-RGO nanocomposites in human liver (HepG2) cells. Potential mechanisms of cytotoxicity of Fe3O4-RGO nanocomposites were further explored through oxidative stress. Prepared samples were characterized by UV-visible spectrophotometer, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and energy dispersive spectroscopy. The results demonstrated that RGO induce dose-dependent cytotoxicity in HepG2 cells. However, Fe3O4-RGO nanocomposites were not toxic. We further noted that RGO induce apoptosis in HepG2 cells, as evidenced by mitochondrial membrane potential loss, higher caspase-3 enzyme activity, and cell cycle arrest. On the other hand, Fe3O4-RGO nanocomposites did not alter these apoptotic parameters. Moreover, we observed that RGO increases intracellular reactive oxygen species and hydrogen peroxide while decrease antioxidant glutathione. Again, Fe3O4-RGO nanocomposites did not exert oxidative stress. Altogether, we found that RGO significantly induced cytotoxicity, apoptosis and oxidative stress. However, Fe3O4-RGO nanocomposites showed good biocompatibility to HepG2 cells. This study warrants further research to investigate the biological response of Fe3O4-RGO nanocomposites at the gene and molecular level.

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Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics

Cited by 132 publications

References 286 publications

Evaluation of the Cytotoxicity and Oxidative Stress Response of CeO2-RGO Nanocomposites in Human Lung Epithelial A549 Cells

Evaluation of the Cytotoxicity and Oxidative Stress Response of CeO2-RGO Nanocomposites in Human Lung Epithelial A549 Cells

Novel NiFe/Si/Au magnetic nanocatalyst: Biogenic synthesis, efficient and reusable catalyst with enhanced visible light photocatalytic degradation and antibacterial activity

Investigation of Cytotoxicity, Apoptosis, and Oxidative Stress Response of Fe3O4-RGO Nanocomposites in Human Liver HepG2 cells

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