Untitled

Abstract

In the present study, the microspheres containing Verapamil hydrochloride xanthan complexes encoated with ethyl cellulose by emulsion solvent evaporation method. DSC shown absence of any new endothermic peak, disappearance of no shift of endothermic peak confirmed that there is no any interaction between drug, excipients and the drug was thermally stable. Drug polymer ratio was altered while the other formulation parameters were kept constant and percentage yield, incorporation efficiency, particle size and distribution of the microcapsules were analyzed. The microcapsules studied for effects of the increase polymer ratio in formulation. The dispersed phase viscosities were evaluated by comparing with variations in particle size and distribution of the microcapsules and the effect of the variation in polymer ratio on drug dissolution was evaluated. The percentage drug released at the end of 12 th h (VXM2) was found be 95.95%. respectively. The mechanism of drug release may also be dissolution and diffusion mechanism controlled released formulation. The stability of Verapamil hydrochloride loaded microcapsules (VXM2) formulation was stored at 40 o C±2 o C/75% RH ±5% RH for three months.Microcapsules offer greater versatility for encapsulation and more triggered release applications than microcapsules. Recent advances in the development of controlled drug release system from natural, semi synthetic and synthetic polymeric carrier systems; it is possible to increase absorption rate and oral bioavailability.Natural polysaccharides and their semi-synthetic derivatives represent a group of polymers that are widely used in pharmaceutical dosage forms and obtained usually as plant exudates containing various sugars moieties other than glucose and having significant quantities of oxidized groups in adjunct to their normal polyhydroxy group. These materials result from normal metabolic processes, and many times, they represent the reserve carbohydrate in that system 1 . Natural polymers such as gaur gum, chitosan, gellan gum, alginic acid, konjac gum, etc. were commonly used for the retarded release of drugs but they have fairly low adhesive properties 2 .Now, a day more emphasis is diverted towards the use of vegetable and nontoxic products which by replacing of synthetic additives with natural one for controlled drug delivery system 3 . In the present work, the controlled drug delivery system using natural, semisynthetics polymers were developed.