2021
DOI: 10.1053/j.gastro.2021.08.015
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AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis

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Cited by 69 publications
(88 citation statements)
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“…Platelet count thresholds are often stipulated for invasive procedures in patients with severe thrombocytopenia related to cirrhosis. Although a specific platelet count cut‐off, below which platelet‐raising treatments is recommended by many international guidelines, there is no firm evidence for this practice 3,4 . From a laboratory perspective, in vitro data suggested a platelet count threshold of 55 × 10 9 /L to be necessary for adequate platelet procoagulant function, but the study did not evaluate the platelet function related to primary hemostasis (i.e., adhesiveness and aggregation) 34 .…”
Section: Procedural Bleeding Risk In Patients With Cirrhosismentioning
confidence: 98%
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“…Platelet count thresholds are often stipulated for invasive procedures in patients with severe thrombocytopenia related to cirrhosis. Although a specific platelet count cut‐off, below which platelet‐raising treatments is recommended by many international guidelines, there is no firm evidence for this practice 3,4 . From a laboratory perspective, in vitro data suggested a platelet count threshold of 55 × 10 9 /L to be necessary for adequate platelet procoagulant function, but the study did not evaluate the platelet function related to primary hemostasis (i.e., adhesiveness and aggregation) 34 .…”
Section: Procedural Bleeding Risk In Patients With Cirrhosismentioning
confidence: 98%
“…Although a specific platelet count cut-off, below which platelet-raising treatments is recommended by many international guidelines, there is no firm evidence for this practice. 3,4 From a laboratory perspective, in vitro data suggested a platelet count threshold of 55 × 10 9 /L to be necessary for adequate platelet procoagulant function, but the study did not evaluate the platelet function related to primary hemostasis (i.e., adhesiveness and aggregation). 34 In an analysis of the in vivo relevance of these in vitro findings, it was noted that 26 patients with cirrhosis who required variceal banding, transfusion of one adult dose of platelets, despite increasing the count, did not have a significant effect on thrombin generation while the minor increment in the platelet count reflected only a small improvement in thromboelastometry markers.…”
Section: Ta B L Ementioning
confidence: 99%
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“…Chronic liver diseases are often associated with portal vein thrombosis (PVT), and anticoagulation is a standard of care for treating PVT. Thus, studies have assessed the pharmacological safety of anticoagulants in patients with advanced chronic liver diseases ( 45 47 ).…”
Section: Coagulation Factors In Organ Fibrosismentioning
confidence: 99%