In the last couple of centuries, the history of physics has at times been sparkled by two opposite attitudes, which to simplify we could denote a radically pessimistic and an overoptimistic one. As a famous representative of the former first camp, we find the German physiologist Emile Du Bois-Reymond, who in a famous speech held in 1880 at the Berlin Academy of science claimed that there were seven world enigmas (Die Sieben Welträtzel) that neither science nor philosophy could ever solve. Among these mysteries, he listed the nature of matter and force, the origin of life, the origin of intelligent thought and the question of free will.As a representative of the overoptimistic camp, we can enlist Lord Kelvin when, a couple of decades later (April 27, 1900) gave a speech at the Royal Institute entitled "Nineteenth-Century Clouds over the Dynamical Theory of Heat and Light", in which he defended the view that physical knowledge was complete, so that the only future task for physicists was the "minor" one of providing more precise experimental measures of already known quantities. However, more realistically, deeply cognizant as he was of contemporary physical theories, mentioned "two clouds" -that as we now know, will lead to a thunderstorm! -namely the failure of Michelson and Morley's experiment and the ultraviolet catastrophe (clouds that have been swept away thanks to the special theory of relativity and to quantum mechanics respectively). By stressing the impassable limits of science, Du Bois-Reymond's Latin motto stirred a strong, optimistic reaction also on the part of the mathematical community. For example, in his 1930 speech at the Society of German Scientists, the great German mathematician David Hilbert expressed the view that: "In opposition to the foolish ignorabimus, our slogan shall be: Wir müssen wissenwir werden wissen". 2 1 We don't know, we will never know 2 "We must know, we will know" is the motto written on Hilbert's tomb.